The involvement of oxidative stress in non-Hodgkin’s lymphomas; a review of the literature
Non-Hodgkin’s malignant lymphomas are a heterogeneous group of hematological malignancies, characterized by a variety of clinical, morphological, histopathological, immuno-histochemical, molecular and evolutionary features. They represent a form of cancer that develops from the lymphatic tissue, as...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Ion Motofei, Carol Davila University
2022-04-01
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| Series: | Journal of Mind and Medical Sciences |
| Subjects: | |
| Online Access: | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1339&context=jmms |
| _version_ | 1818022805408579584 |
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| author | Ramona Ingrid Corbeanu Amelia Maria Găman |
| author_facet | Ramona Ingrid Corbeanu Amelia Maria Găman |
| author_sort | Ramona Ingrid Corbeanu |
| collection | DOAJ |
| description | Non-Hodgkin’s malignant lymphomas are a heterogeneous group of hematological malignancies, characterized by a variety of clinical, morphological, histopathological, immuno-histochemical, molecular and evolutionary features. They represent a form of cancer that develops from the lymphatic tissue, as a result of the malignant transformation of B (85%) or T (15%) lymphocytes. Lymphomagenesis is described as a multi-stage process involving the mutation and proliferation of cell clones. Oxidative stress is defined as an imbalance of cellular redox status caused by the production of reactive oxygen species (ROS) and/ or by decreasing antioxidant systems that allows their accumulation in the cell. Small quantities of ROS are involved in physiological mechanisms such as cell growth and differentiation, cell signaling, antimicrobial defense, phagocytosis. Normally, cells are capable of defending themselves against ROS damage through various scavenger systems. On the other hand, excessive ROS contribute to various diseases such as carcinogenesis, ischemia, atherosclerosis, neurodegenerative diseases. Oxidative stress exerts noxious effects on the cell structures by inducing structural changes in membranes, lipids, proteins or DNA. The present review summarizes the latest findings in understanding the ROS-linked signaling pathways in the initiation of lymphomagenesis, disease progression, metastasis, as well as in the pharmacodynamics of specific treatments for this malignancy. |
| first_indexed | 2024-12-10T03:34:16Z |
| format | Article |
| id | doaj.art-c5e6f2b9afb04ea7aa0a7082cf76e1ad |
| institution | Directory Open Access Journal |
| issn | 2392-7674 |
| language | English |
| last_indexed | 2024-12-10T03:34:16Z |
| publishDate | 2022-04-01 |
| publisher | Ion Motofei, Carol Davila University |
| record_format | Article |
| series | Journal of Mind and Medical Sciences |
| spelling | doaj.art-c5e6f2b9afb04ea7aa0a7082cf76e1ad2022-12-22T02:03:45ZengIon Motofei, Carol Davila UniversityJournal of Mind and Medical Sciences2392-76742022-04-019111510.22543/7674.91.P115The involvement of oxidative stress in non-Hodgkin’s lymphomas; a review of the literatureRamona Ingrid Corbeanu0Amelia Maria Găman1UNIVERSITY OF MEDICINE AND PHARMACY OF CRAIOVA, DEPARTMENT OF PATHOPHYSIOLOGY, CRAIOVA, ROMANIAUNIVERSITY OF MEDICINE AND PHARMACY OF CRAIOVA, DEPARTMENT OF PATHOPHYSIOLOGY, CRAIOVA, ROMANIANon-Hodgkin’s malignant lymphomas are a heterogeneous group of hematological malignancies, characterized by a variety of clinical, morphological, histopathological, immuno-histochemical, molecular and evolutionary features. They represent a form of cancer that develops from the lymphatic tissue, as a result of the malignant transformation of B (85%) or T (15%) lymphocytes. Lymphomagenesis is described as a multi-stage process involving the mutation and proliferation of cell clones. Oxidative stress is defined as an imbalance of cellular redox status caused by the production of reactive oxygen species (ROS) and/ or by decreasing antioxidant systems that allows their accumulation in the cell. Small quantities of ROS are involved in physiological mechanisms such as cell growth and differentiation, cell signaling, antimicrobial defense, phagocytosis. Normally, cells are capable of defending themselves against ROS damage through various scavenger systems. On the other hand, excessive ROS contribute to various diseases such as carcinogenesis, ischemia, atherosclerosis, neurodegenerative diseases. Oxidative stress exerts noxious effects on the cell structures by inducing structural changes in membranes, lipids, proteins or DNA. The present review summarizes the latest findings in understanding the ROS-linked signaling pathways in the initiation of lymphomagenesis, disease progression, metastasis, as well as in the pharmacodynamics of specific treatments for this malignancy. https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1339&context=jmmsreactive oxygen speciesoxidative stressantioxidantsdna damagelymphomagenesisnon-hodgkin’s lymphoma |
| spellingShingle | Ramona Ingrid Corbeanu Amelia Maria Găman The involvement of oxidative stress in non-Hodgkin’s lymphomas; a review of the literature Journal of Mind and Medical Sciences reactive oxygen species oxidative stress antioxidants dna damage lymphomagenesis non-hodgkin’s lymphoma |
| title | The involvement of oxidative stress in non-Hodgkin’s lymphomas; a review of the literature |
| title_full | The involvement of oxidative stress in non-Hodgkin’s lymphomas; a review of the literature |
| title_fullStr | The involvement of oxidative stress in non-Hodgkin’s lymphomas; a review of the literature |
| title_full_unstemmed | The involvement of oxidative stress in non-Hodgkin’s lymphomas; a review of the literature |
| title_short | The involvement of oxidative stress in non-Hodgkin’s lymphomas; a review of the literature |
| title_sort | involvement of oxidative stress in non hodgkin s lymphomas a review of the literature |
| topic | reactive oxygen species oxidative stress antioxidants dna damage lymphomagenesis non-hodgkin’s lymphoma |
| url | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1339&context=jmms |
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