Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin
Curcumin (CCM) is one of the most frequently explored plant compounds with various biological actions such as antibacterial, antiviral, antifungal, antineoplastic, and antioxidant/anti-inflammatory properties. The laboratory data and clinical trials have demonstrated that the bioavailability and bio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/20/6854 |
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| author | Levente Zsolt Racz Csaba Pal Racz Lucian-Cristian Pop Gheorghe Tomoaia Aurora Mocanu Ioana Barbu Melinda Sárközi Ioana Roman Alexandra Avram Maria Tomoaia-Cotisel Vlad-Alexandru Toma |
| author_facet | Levente Zsolt Racz Csaba Pal Racz Lucian-Cristian Pop Gheorghe Tomoaia Aurora Mocanu Ioana Barbu Melinda Sárközi Ioana Roman Alexandra Avram Maria Tomoaia-Cotisel Vlad-Alexandru Toma |
| author_sort | Levente Zsolt Racz |
| collection | DOAJ |
| description | Curcumin (CCM) is one of the most frequently explored plant compounds with various biological actions such as antibacterial, antiviral, antifungal, antineoplastic, and antioxidant/anti-inflammatory properties. The laboratory data and clinical trials have demonstrated that the bioavailability and bioactivity of curcumin are influenced by the feature of the curcumin molecular complex types. Curcumin has a high capacity to form molecular complexes with proteins (such as whey proteins, bovine serum albumin, β-lactoglobulin), carbohydrates, lipids, and natural compounds (e.g., resveratrol, piperine, quercetin). These complexes increase the bioactivity and bioavailability of curcumin. The current review provides these derivatization strategies for curcumin in terms of biological and physico-chemical aspects with a strong focus on different type of proteins, characterization methods, and thermodynamic features of protein–curcumin complexes, and with the aim of evaluating the best performances. The current literature review offers, taking into consideration various biological effects of the CCM, a whole approach for CCM-biomolecules interactions such as CCM-proteins, CCM-nanomaterials, and CCM-natural compounds regarding molecular strategies to improve the bioactivity as well as the bioavailability of curcumin in biological systems. |
| first_indexed | 2024-03-09T19:42:44Z |
| format | Article |
| id | doaj.art-c5e93bb366464cb1a8e720708fc1e6e3 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T19:42:44Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c5e93bb366464cb1a8e720708fc1e6e32023-11-24T01:32:24ZengMDPI AGMolecules1420-30492022-10-012720685410.3390/molecules27206854Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of CurcuminLevente Zsolt Racz0Csaba Pal Racz1Lucian-Cristian Pop2Gheorghe Tomoaia3Aurora Mocanu4Ioana Barbu5Melinda Sárközi6Ioana Roman7Alexandra Avram8Maria Tomoaia-Cotisel9Vlad-Alexandru Toma10Research Center in Physical Chemistry, Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University of Cluj-Napoca, 11 Arany Janos Str., RO-400028 Cluj-Napoca, RomaniaResearch Center in Physical Chemistry, Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University of Cluj-Napoca, 11 Arany Janos Str., RO-400028 Cluj-Napoca, RomaniaResearch Center in Physical Chemistry, Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University of Cluj-Napoca, 11 Arany Janos Str., RO-400028 Cluj-Napoca, RomaniaDepartment of Orthopedics and Traumatology, Iuliu Hatieganu University of Medicine and Pharmacy, 47 Gen. Traian Mosoiu Str., RO-400132 Cluj-Napoca, RomaniaResearch Center in Physical Chemistry, Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University of Cluj-Napoca, 11 Arany Janos Str., RO-400028 Cluj-Napoca, RomaniaFaculty of Biology and Geology, Babes-Bolyai University, 4-6 Clinicilor Str., RO-400006 Cluj-Napoca, RomaniaSC. Parapharm SRL, 9 Dacilor Str., RO-335200 Brad, RomaniaInstitute of Biological Research, Branch of NIRDBS Bucharest, 48 Republicii Str., RO-400015 Cluj-Napoca, RomaniaResearch Center in Physical Chemistry, Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University of Cluj-Napoca, 11 Arany Janos Str., RO-400028 Cluj-Napoca, RomaniaResearch Center in Physical Chemistry, Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University of Cluj-Napoca, 11 Arany Janos Str., RO-400028 Cluj-Napoca, RomaniaFaculty of Biology and Geology, Babes-Bolyai University, 4-6 Clinicilor Str., RO-400006 Cluj-Napoca, RomaniaCurcumin (CCM) is one of the most frequently explored plant compounds with various biological actions such as antibacterial, antiviral, antifungal, antineoplastic, and antioxidant/anti-inflammatory properties. The laboratory data and clinical trials have demonstrated that the bioavailability and bioactivity of curcumin are influenced by the feature of the curcumin molecular complex types. Curcumin has a high capacity to form molecular complexes with proteins (such as whey proteins, bovine serum albumin, β-lactoglobulin), carbohydrates, lipids, and natural compounds (e.g., resveratrol, piperine, quercetin). These complexes increase the bioactivity and bioavailability of curcumin. The current review provides these derivatization strategies for curcumin in terms of biological and physico-chemical aspects with a strong focus on different type of proteins, characterization methods, and thermodynamic features of protein–curcumin complexes, and with the aim of evaluating the best performances. The current literature review offers, taking into consideration various biological effects of the CCM, a whole approach for CCM-biomolecules interactions such as CCM-proteins, CCM-nanomaterials, and CCM-natural compounds regarding molecular strategies to improve the bioactivity as well as the bioavailability of curcumin in biological systems.https://www.mdpi.com/1420-3049/27/20/6854bioavailabilitytherapeutic propertiesprotein–curcumin interactionswhey proteinsβ-lactoglobulincurcumin complexes |
| spellingShingle | Levente Zsolt Racz Csaba Pal Racz Lucian-Cristian Pop Gheorghe Tomoaia Aurora Mocanu Ioana Barbu Melinda Sárközi Ioana Roman Alexandra Avram Maria Tomoaia-Cotisel Vlad-Alexandru Toma Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin Molecules bioavailability therapeutic properties protein–curcumin interactions whey proteins β-lactoglobulin curcumin complexes |
| title | Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin |
| title_full | Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin |
| title_fullStr | Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin |
| title_full_unstemmed | Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin |
| title_short | Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin |
| title_sort | strategies for improving bioavailability bioactivity and physical chemical behavior of curcumin |
| topic | bioavailability therapeutic properties protein–curcumin interactions whey proteins β-lactoglobulin curcumin complexes |
| url | https://www.mdpi.com/1420-3049/27/20/6854 |
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