Corneal graft survival analysis after penetrating keratoplasty in a retrospective cohort study
Purpose. To assess the results of penetrating keratoplasty and identify the risk factors for the graft disease (GD) development. Material and methods. Data of 582 patients after corneal transplantation performed in the period since 2011 to 2019 for keratoconus (41%), as well for corneal leucorrhoea...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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Publishing house "Ophthalmology"
2021-12-01
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| Series: | Офтальмохирургия |
| Subjects: | |
| Online Access: | https://www.ophthalmosurgery.ru/jour/article/view/803 |
| _version_ | 1797946663134822400 |
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| author | B. E. Malyugin S. N. Sakhnov V. V. Myasnikova A. V. Klokov S. L. Kirsanov R. Z. Shu |
| author_facet | B. E. Malyugin S. N. Sakhnov V. V. Myasnikova A. V. Klokov S. L. Kirsanov R. Z. Shu |
| author_sort | B. E. Malyugin |
| collection | DOAJ |
| description | Purpose. To assess the results of penetrating keratoplasty and identify the risk factors for the graft disease (GD) development. Material and methods. Data of 582 patients after corneal transplantation performed in the period since 2011 to 2019 for keratoconus (41%), as well for corneal leucorrhoea and dystrophies (59%), aggravated by concomitant pathology, the so-called high-risk keratoplasty (HRK) were analyzed in a retrospective cohort study. We estimated the functional results and incidence of GD. The calculation of the t-criterion; cross-tabulation method; Kaplan–Meier survival analysis and multivariate analysis were applied.Results. As a result of penetrating keratoplasty, the BCVA (best corrected visual acuity) in patients with keratoconus increased by 20%; in patients with HRK – by 8%. In the general group the graft survival rate was 72%, while the 8-year successful graft engraftment in patients with keratoconus comprised 91%, with HRK – 60%. A significant relationship of the GD development with preoperative diagnosis and rekeratoplasty was determined. The risk of GD incidence was minimal in patients under 30 years of age and maximum in patients aged from 50 to 70 years. Survival rates for corneal transplants were better in men than in women.Conclusion. Penetrating keratoplasty in patients with keratoconus provides a good functional result with a minimal risk of GD development. With penetrating keratoplasty in high-risk patients, the effectiveness of surgical interventions is significantly lower (by ~30%). |
| first_indexed | 2024-04-10T21:14:35Z |
| format | Article |
| id | doaj.art-c5e9e53386c048ae93062cbd7888165c |
| institution | Directory Open Access Journal |
| issn | 0235-4160 2312-4970 |
| language | Russian |
| last_indexed | 2024-04-10T21:14:35Z |
| publishDate | 2021-12-01 |
| publisher | Publishing house "Ophthalmology" |
| record_format | Article |
| series | Офтальмохирургия |
| spelling | doaj.art-c5e9e53386c048ae93062cbd7888165c2023-01-20T12:34:52ZrusPublishing house "Ophthalmology"Офтальмохирургия0235-41602312-49702021-12-0104122010.25276/0235-4160-2021-4-12-20531Corneal graft survival analysis after penetrating keratoplasty in a retrospective cohort studyB. E. Malyugin0S. N. Sakhnov1V. V. Myasnikova2A. V. Klokov3S. L. Kirsanov4R. Z. Shu5Fyodorov Eye Microsurger y Federal State Institution; Yevdokimov Moscow State University of Medicine and DentistryFyodorov Eye Microsurger y Federal State Institution, Krasnodar Branch; Kuban State Medical UniversityFyodorov Eye Microsurger y Federal State Institution, Krasnodar Branch; Kuban State Medical UniversityFyodorov Eye Microsurger y Federal State Institution, Krasnodar BranchFyodorov Eye Microsurger y Federal State Institution, Krasnodar BranchFyodorov Eye Microsurger y Federal State Institution, Krasnodar BranchPurpose. To assess the results of penetrating keratoplasty and identify the risk factors for the graft disease (GD) development. Material and methods. Data of 582 patients after corneal transplantation performed in the period since 2011 to 2019 for keratoconus (41%), as well for corneal leucorrhoea and dystrophies (59%), aggravated by concomitant pathology, the so-called high-risk keratoplasty (HRK) were analyzed in a retrospective cohort study. We estimated the functional results and incidence of GD. The calculation of the t-criterion; cross-tabulation method; Kaplan–Meier survival analysis and multivariate analysis were applied.Results. As a result of penetrating keratoplasty, the BCVA (best corrected visual acuity) in patients with keratoconus increased by 20%; in patients with HRK – by 8%. In the general group the graft survival rate was 72%, while the 8-year successful graft engraftment in patients with keratoconus comprised 91%, with HRK – 60%. A significant relationship of the GD development with preoperative diagnosis and rekeratoplasty was determined. The risk of GD incidence was minimal in patients under 30 years of age and maximum in patients aged from 50 to 70 years. Survival rates for corneal transplants were better in men than in women.Conclusion. Penetrating keratoplasty in patients with keratoconus provides a good functional result with a minimal risk of GD development. With penetrating keratoplasty in high-risk patients, the effectiveness of surgical interventions is significantly lower (by ~30%).https://www.ophthalmosurgery.ru/jour/article/view/803keratoconuspenetrating keratoplastycorneal transplantationsurvival analysis |
| spellingShingle | B. E. Malyugin S. N. Sakhnov V. V. Myasnikova A. V. Klokov S. L. Kirsanov R. Z. Shu Corneal graft survival analysis after penetrating keratoplasty in a retrospective cohort study Офтальмохирургия keratoconus penetrating keratoplasty corneal transplantation survival analysis |
| title | Corneal graft survival analysis after penetrating keratoplasty in a retrospective cohort study |
| title_full | Corneal graft survival analysis after penetrating keratoplasty in a retrospective cohort study |
| title_fullStr | Corneal graft survival analysis after penetrating keratoplasty in a retrospective cohort study |
| title_full_unstemmed | Corneal graft survival analysis after penetrating keratoplasty in a retrospective cohort study |
| title_short | Corneal graft survival analysis after penetrating keratoplasty in a retrospective cohort study |
| title_sort | corneal graft survival analysis after penetrating keratoplasty in a retrospective cohort study |
| topic | keratoconus penetrating keratoplasty corneal transplantation survival analysis |
| url | https://www.ophthalmosurgery.ru/jour/article/view/803 |
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