The Impact of Patient Characteristics and Tumor Biology on the Accuracy of Preoperative Staging of Colon Cancer in Denmark. A Nationwide Cohort Study
Background: Colon cancer is a common disease in western populations. The aim of this study was to assess the impact of mismatch repair (MMR) deficiency and other patient and tumor characteristics on the accuracy of preoperative staging by comparing histopathological T- and N-categories of the resect...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/17/4384 |
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| author | Malene Roland V. Pedersen Søren Rafael Rafaelsen Jan Lindebjerg Torben Frøstrup Hansen Hans Bjarke Rahr |
| author_facet | Malene Roland V. Pedersen Søren Rafael Rafaelsen Jan Lindebjerg Torben Frøstrup Hansen Hans Bjarke Rahr |
| author_sort | Malene Roland V. Pedersen |
| collection | DOAJ |
| description | Background: Colon cancer is a common disease in western populations. The aim of this study was to assess the impact of mismatch repair (MMR) deficiency and other patient and tumor characteristics on the accuracy of preoperative staging by comparing histopathological T- and N-categories of the resected specimen with the preoperative clinical stage in a nationwide cohort of patients treated for colon cancer by elective bowel resection with curative intent. Methods: A register study of a cohort extracted from the Danish Colorectal Cancer Group (DCCG) database, which holds prospective data on all new cases of colon and rectum cancer in Denmark. Patients diagnosed with colon cancer and treated with an elective bowel resection with curative intent in the years 2016–2019 were analyzed. Results: A total of 6102 patients were included (<i>n</i> = 3161 (52%) men and <i>n</i> = 2941 (48%) women) with a median age of 72 years (range 23–97 years). MMR was deficient in 24% of the patients and proficient in 76%. MMR deficiency, tumor sidedness and histopathological type were significant predictors of the accuracy of preoperative staging of colon cancer in univariate and multivariate analysis. MMR status in particular showed a strong impact on the risk of overstaging. Conclusions: MMR deficiency, but also tumor sidedness and to some degree histopathological type, impacted the accuracy of preoperative staging of colon cancer. MMR status should be taken into consideration in everyday clinical staging. |
| first_indexed | 2024-03-10T08:15:00Z |
| format | Article |
| id | doaj.art-c5eaa4a7ee614476a800e857be480e53 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T08:15:00Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-c5eaa4a7ee614476a800e857be480e532023-11-22T10:26:36ZengMDPI AGCancers2072-66942021-08-011317438410.3390/cancers13174384The Impact of Patient Characteristics and Tumor Biology on the Accuracy of Preoperative Staging of Colon Cancer in Denmark. A Nationwide Cohort StudyMalene Roland V. Pedersen0Søren Rafael Rafaelsen1Jan Lindebjerg2Torben Frøstrup Hansen3Hans Bjarke Rahr4Department of Radiology, Vejle Hospital, University Hospital of Southern Denmark, DK-7100 Vejle, DenmarkDepartment of Radiology, Vejle Hospital, University Hospital of Southern Denmark, DK-7100 Vejle, DenmarkDepartment of Regional Health Research, University of Southern Denmark, DK-7100 Vejle, DenmarkDepartment of Regional Health Research, University of Southern Denmark, DK-7100 Vejle, DenmarkDepartment of Regional Health Research, University of Southern Denmark, DK-7100 Vejle, DenmarkBackground: Colon cancer is a common disease in western populations. The aim of this study was to assess the impact of mismatch repair (MMR) deficiency and other patient and tumor characteristics on the accuracy of preoperative staging by comparing histopathological T- and N-categories of the resected specimen with the preoperative clinical stage in a nationwide cohort of patients treated for colon cancer by elective bowel resection with curative intent. Methods: A register study of a cohort extracted from the Danish Colorectal Cancer Group (DCCG) database, which holds prospective data on all new cases of colon and rectum cancer in Denmark. Patients diagnosed with colon cancer and treated with an elective bowel resection with curative intent in the years 2016–2019 were analyzed. Results: A total of 6102 patients were included (<i>n</i> = 3161 (52%) men and <i>n</i> = 2941 (48%) women) with a median age of 72 years (range 23–97 years). MMR was deficient in 24% of the patients and proficient in 76%. MMR deficiency, tumor sidedness and histopathological type were significant predictors of the accuracy of preoperative staging of colon cancer in univariate and multivariate analysis. MMR status in particular showed a strong impact on the risk of overstaging. Conclusions: MMR deficiency, but also tumor sidedness and to some degree histopathological type, impacted the accuracy of preoperative staging of colon cancer. MMR status should be taken into consideration in everyday clinical staging.https://www.mdpi.com/2072-6694/13/17/4384mismatch repaircolon cancerregistry studytumor staging |
| spellingShingle | Malene Roland V. Pedersen Søren Rafael Rafaelsen Jan Lindebjerg Torben Frøstrup Hansen Hans Bjarke Rahr The Impact of Patient Characteristics and Tumor Biology on the Accuracy of Preoperative Staging of Colon Cancer in Denmark. A Nationwide Cohort Study Cancers mismatch repair colon cancer registry study tumor staging |
| title | The Impact of Patient Characteristics and Tumor Biology on the Accuracy of Preoperative Staging of Colon Cancer in Denmark. A Nationwide Cohort Study |
| title_full | The Impact of Patient Characteristics and Tumor Biology on the Accuracy of Preoperative Staging of Colon Cancer in Denmark. A Nationwide Cohort Study |
| title_fullStr | The Impact of Patient Characteristics and Tumor Biology on the Accuracy of Preoperative Staging of Colon Cancer in Denmark. A Nationwide Cohort Study |
| title_full_unstemmed | The Impact of Patient Characteristics and Tumor Biology on the Accuracy of Preoperative Staging of Colon Cancer in Denmark. A Nationwide Cohort Study |
| title_short | The Impact of Patient Characteristics and Tumor Biology on the Accuracy of Preoperative Staging of Colon Cancer in Denmark. A Nationwide Cohort Study |
| title_sort | impact of patient characteristics and tumor biology on the accuracy of preoperative staging of colon cancer in denmark a nationwide cohort study |
| topic | mismatch repair colon cancer registry study tumor staging |
| url | https://www.mdpi.com/2072-6694/13/17/4384 |
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