PTH regulates osteogenesis and suppresses adipogenesis through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner

PTH regulates osteogenesis and suppresses adipogenesis through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner

Conditional deletion of the PTH1R in mesenchymal progenitors reduces osteoblast differentiation, enhances marrow adipogenesis, and increases zinc finger protein 467 (Zfp467) expression. In contrast, genetic loss of Zfp467 increased Pth1r expression and shifts mesenchymal progenitor cell fate toward...

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Bibliographic Details
Main Authors: Hanghang Liu, Akane Wada, Isabella Le, Phuong T Le, Andrew WF Lee, Jun Zhou, Francesca Gori, Roland Baron, Clifford J Rosen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-04-01
Series:eLife
Subjects:
zinc finger protein 467
PTH receptor
PTH
PKA pathway
osteogenesis
Online Access:https://elifesciences.org/articles/83345

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