Physicochemical stability of azacitidine suspensions at 25 mg/mL in polypropylene syringes stored under different conditions of storage
Azacitidine is a pyrimidine nucleoside analogue whose stability is temperature dependent. Numerous publications have studied the stability of this drug with discordant results. The purpose of this work is to study the stability of azacitidine suspensions under different conditions to allow preparati...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-06-01
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| Series: | Pharmaceutical Technology in Hospital Pharmacy |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/pthp-2022-0003 |
| _version_ | 1828154436619337728 |
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| author | Trambloy Quentin Vigneron Jean Clarot Igor Blaise Franck D’Huart Elise Demoré Béatrice |
| author_facet | Trambloy Quentin Vigneron Jean Clarot Igor Blaise Franck D’Huart Elise Demoré Béatrice |
| author_sort | Trambloy Quentin |
| collection | DOAJ |
| description | Azacitidine is a pyrimidine nucleoside analogue whose stability is temperature dependent. Numerous publications have studied the stability of this drug with discordant results. The purpose of this work is to study the stability of azacitidine suspensions under different conditions to allow preparation in advance: vials stored at room temperature or between 2 and 8 °C, reconstituted with refrigerated water for injection (WFI) or frozen/thawed WFI, azacitidine suspensions stored at room temperature, 2–8 °C or at −20 °C. The feasibility of a vented ChemoClave® Spike vial was also tested to reconstitute and collect azacitidine to aid the preparation stage. |
| first_indexed | 2024-04-11T22:39:59Z |
| format | Article |
| id | doaj.art-c5eacfdbe5cc4b538a5ff9973c84b59f |
| institution | Directory Open Access Journal |
| issn | 2365-2411 2365-242X |
| language | English |
| last_indexed | 2024-04-11T22:39:59Z |
| publishDate | 2022-06-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Pharmaceutical Technology in Hospital Pharmacy |
| spelling | doaj.art-c5eacfdbe5cc4b538a5ff9973c84b59f2022-12-22T03:59:02ZengDe GruyterPharmaceutical Technology in Hospital Pharmacy2365-24112365-242X2022-06-017111610.1515/pthp-2022-0003Physicochemical stability of azacitidine suspensions at 25 mg/mL in polypropylene syringes stored under different conditions of storageTrambloy Quentin0Vigneron Jean1Clarot Igor2Blaise Franck3D’Huart Elise4Demoré Béatrice5Pharmacy Department, University HospitalVandœuvre-lès-Nancy, FrancePharmacy Department, University HospitalVandœuvre-lès-Nancy, FranceUniversité de LorraineNancy, FrancePharmacy Department, University HospitalVandœuvre-lès-Nancy, FrancePharmacy Department, University HospitalVandœuvre-lès-Nancy, FrancePharmacy Department, University HospitalVandœuvre-lès-Nancy, FranceAzacitidine is a pyrimidine nucleoside analogue whose stability is temperature dependent. Numerous publications have studied the stability of this drug with discordant results. The purpose of this work is to study the stability of azacitidine suspensions under different conditions to allow preparation in advance: vials stored at room temperature or between 2 and 8 °C, reconstituted with refrigerated water for injection (WFI) or frozen/thawed WFI, azacitidine suspensions stored at room temperature, 2–8 °C or at −20 °C. The feasibility of a vented ChemoClave® Spike vial was also tested to reconstitute and collect azacitidine to aid the preparation stage.https://doi.org/10.1515/pthp-2022-0003administrationazacitidinestabilitysuspension |
| spellingShingle | Trambloy Quentin Vigneron Jean Clarot Igor Blaise Franck D’Huart Elise Demoré Béatrice Physicochemical stability of azacitidine suspensions at 25 mg/mL in polypropylene syringes stored under different conditions of storage Pharmaceutical Technology in Hospital Pharmacy administration azacitidine stability suspension |
| title | Physicochemical stability of azacitidine suspensions at 25 mg/mL in polypropylene syringes stored under different conditions of storage |
| title_full | Physicochemical stability of azacitidine suspensions at 25 mg/mL in polypropylene syringes stored under different conditions of storage |
| title_fullStr | Physicochemical stability of azacitidine suspensions at 25 mg/mL in polypropylene syringes stored under different conditions of storage |
| title_full_unstemmed | Physicochemical stability of azacitidine suspensions at 25 mg/mL in polypropylene syringes stored under different conditions of storage |
| title_short | Physicochemical stability of azacitidine suspensions at 25 mg/mL in polypropylene syringes stored under different conditions of storage |
| title_sort | physicochemical stability of azacitidine suspensions at 25 mg ml in polypropylene syringes stored under different conditions of storage |
| topic | administration azacitidine stability suspension |
| url | https://doi.org/10.1515/pthp-2022-0003 |
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