Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection

Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection

Abstract Modified vaccinia Ankara (MVA) virus does not replicate in human cells and is the vaccine deployed to curb the current outbreak of mpox. Here, we conduct a multiplexed proteomic analysis to quantify >9000 cellular and ~80% of viral proteins throughout MVA infection of human fibroblasts a...

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Bibliographic Details
Main Authors: Jonas D. Albarnaz, Joanne Kite, Marisa Oliveira, Hanqi Li, Ying Di, Maria H. Christensen, Joao A. Paulo, Robin Antrobus, Steven P. Gygi, Florian I. Schmidt, Edward L. Huttlin, Geoffrey L. Smith, Michael P. Weekes
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43299-8

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https://doi.org/10.1038/s41467-023-43299-8

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