CXCR1 and its downstream NF-κB inflammation signaling pathway as a key target of Guanxinning injection for myocardial ischemia/reperfusion injury

CXCR1 and its downstream NF-κB inflammation signaling pathway as a key target of Guanxinning injection for myocardial ischemia/reperfusion injury

Guanxinning Injection (GXNI) is used clinically to treat cardiac injury, but its active components and mode of action remains unclear. Therefore, a myocardial ischemia/reperfusion injury (MIRI) model-based integrated strategy including function evaluation, RNA-seq analysis, molecular docking, and ce...

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Bibliographic Details
Main Authors: Guangxu Xiao, Jiaxu Liu, Huanyi Wang, Shuang He, Jianwei Liu, Guanwei Fan, Ming Lyu, Yan Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
Guanxinning injection
Myocardial ischemia/reperfusion injury
Danshensu
CXCR1
IL-8 signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1007341/full

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