Microneedle Sensors for Point‐of‐Care Diagnostics
Abstract Point‐of‐care (POC) has the capacity to support low‐cost, accurate and real‐time actionable diagnostic data. Microneedle sensors have received considerable attention as an emerging technique to evolve blood‐based diagnostics owing to their direct and painless access to a rich source of biom...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202306560 |
| _version_ | 1797242708848279552 |
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| author | Yubing Hu Eleni Chatzilakou Zhisheng Pan Giovanni Traverso Ali K. Yetisen |
| author_facet | Yubing Hu Eleni Chatzilakou Zhisheng Pan Giovanni Traverso Ali K. Yetisen |
| author_sort | Yubing Hu |
| collection | DOAJ |
| description | Abstract Point‐of‐care (POC) has the capacity to support low‐cost, accurate and real‐time actionable diagnostic data. Microneedle sensors have received considerable attention as an emerging technique to evolve blood‐based diagnostics owing to their direct and painless access to a rich source of biomarkers from interstitial fluid. This review systematically summarizes the recent innovations in microneedle sensors with a particular focus on their utility in POC diagnostics and personalized medicine. The integration of various sensing techniques, mostly electrochemical and optical sensing, has been established in diverse architectures of “lab‐on‐a‐microneedle” platforms. Microneedle sensors with tailored geometries, mechanical flexibility, and biocompatibility are constructed with a variety of materials and fabrication methods. Microneedles categorized into four types: metals, inorganics, polymers, and hydrogels, have been elaborated with state‐of‐the‐art bioengineering strategies for minimally invasive, continuous, and multiplexed sensing. Microneedle sensors have been employed to detect a wide range of biomarkers from electrolytes, metabolites, polysaccharides, nucleic acids, proteins to drugs. Insightful perspectives are outlined from biofluid, microneedles, biosensors, POC devices, and theragnostic instruments, which depict a bright future of the upcoming personalized and intelligent health management. |
| first_indexed | 2024-04-24T18:43:31Z |
| format | Article |
| id | doaj.art-c5f0d890d5714e1fb4bff73034e76925 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-24T18:43:31Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-c5f0d890d5714e1fb4bff73034e769252024-03-27T09:39:52ZengWileyAdvanced Science2198-38442024-03-011112n/an/a10.1002/advs.202306560Microneedle Sensors for Point‐of‐Care DiagnosticsYubing Hu0Eleni Chatzilakou1Zhisheng Pan2Giovanni Traverso3Ali K. Yetisen4Department of Chemical Engineering Imperial College London London SW7 2AZ UKDepartment of Chemical Engineering Imperial College London London SW7 2AZ UKDepartment of Chemical Engineering Imperial College London London SW7 2AZ UKDepartment of Mechanical Engineering Massachusetts Institute of Technology Cambridge MA 02139 USADepartment of Chemical Engineering Imperial College London London SW7 2AZ UKAbstract Point‐of‐care (POC) has the capacity to support low‐cost, accurate and real‐time actionable diagnostic data. Microneedle sensors have received considerable attention as an emerging technique to evolve blood‐based diagnostics owing to their direct and painless access to a rich source of biomarkers from interstitial fluid. This review systematically summarizes the recent innovations in microneedle sensors with a particular focus on their utility in POC diagnostics and personalized medicine. The integration of various sensing techniques, mostly electrochemical and optical sensing, has been established in diverse architectures of “lab‐on‐a‐microneedle” platforms. Microneedle sensors with tailored geometries, mechanical flexibility, and biocompatibility are constructed with a variety of materials and fabrication methods. Microneedles categorized into four types: metals, inorganics, polymers, and hydrogels, have been elaborated with state‐of‐the‐art bioengineering strategies for minimally invasive, continuous, and multiplexed sensing. Microneedle sensors have been employed to detect a wide range of biomarkers from electrolytes, metabolites, polysaccharides, nucleic acids, proteins to drugs. Insightful perspectives are outlined from biofluid, microneedles, biosensors, POC devices, and theragnostic instruments, which depict a bright future of the upcoming personalized and intelligent health management.https://doi.org/10.1002/advs.202306560biosensorsdiagnosismicroneedlespoint‐of‐caretransdermal monitoring |
| spellingShingle | Yubing Hu Eleni Chatzilakou Zhisheng Pan Giovanni Traverso Ali K. Yetisen Microneedle Sensors for Point‐of‐Care Diagnostics Advanced Science biosensors diagnosis microneedles point‐of‐care transdermal monitoring |
| title | Microneedle Sensors for Point‐of‐Care Diagnostics |
| title_full | Microneedle Sensors for Point‐of‐Care Diagnostics |
| title_fullStr | Microneedle Sensors for Point‐of‐Care Diagnostics |
| title_full_unstemmed | Microneedle Sensors for Point‐of‐Care Diagnostics |
| title_short | Microneedle Sensors for Point‐of‐Care Diagnostics |
| title_sort | microneedle sensors for point of care diagnostics |
| topic | biosensors diagnosis microneedles point‐of‐care transdermal monitoring |
| url | https://doi.org/10.1002/advs.202306560 |
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