A binding cooperativity switch driven by synergistic structural swelling of an osmo-regulatory protein pair
The bacterial protein Cnu together with the transcription repressor H-NS regulate expression of virulence factors in an osmo-sensitive manner. Here authors show that the structure of Cnu swells with decreasing ionic strength driving the oligomerization of H-NS and regulating osmo-sensory response.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10002-9 |
| _version_ | 1818991710468833280 |
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| author | Abhishek Narayan Soundhararajan Gopi David Fushman Athi N. Naganathan |
| author_facet | Abhishek Narayan Soundhararajan Gopi David Fushman Athi N. Naganathan |
| author_sort | Abhishek Narayan |
| collection | DOAJ |
| description | The bacterial protein Cnu together with the transcription repressor H-NS regulate expression of virulence factors in an osmo-sensitive manner. Here authors show that the structure of Cnu swells with decreasing ionic strength driving the oligomerization of H-NS and regulating osmo-sensory response. |
| first_indexed | 2024-12-20T20:14:36Z |
| format | Article |
| id | doaj.art-c5f2bfeffc4b4a10bc4d15207c703514 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:14:36Z |
| publishDate | 2019-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c5f2bfeffc4b4a10bc4d15207c7035142022-12-21T19:27:45ZengNature PortfolioNature Communications2041-17232019-04-011011910.1038/s41467-019-10002-9A binding cooperativity switch driven by synergistic structural swelling of an osmo-regulatory protein pairAbhishek Narayan0Soundhararajan Gopi1David Fushman2Athi N. Naganathan3Department of Biotechnology, Bhupat & Jyoti Mehta School of Biosciences, Indian Institute of Technology MadrasDepartment of Biotechnology, Bhupat & Jyoti Mehta School of Biosciences, Indian Institute of Technology MadrasCenter for Biomolecular Structure and Organization, Department of Chemistry & Biochemistry, University of MarylandDepartment of Biotechnology, Bhupat & Jyoti Mehta School of Biosciences, Indian Institute of Technology MadrasThe bacterial protein Cnu together with the transcription repressor H-NS regulate expression of virulence factors in an osmo-sensitive manner. Here authors show that the structure of Cnu swells with decreasing ionic strength driving the oligomerization of H-NS and regulating osmo-sensory response.https://doi.org/10.1038/s41467-019-10002-9 |
| spellingShingle | Abhishek Narayan Soundhararajan Gopi David Fushman Athi N. Naganathan A binding cooperativity switch driven by synergistic structural swelling of an osmo-regulatory protein pair Nature Communications |
| title | A binding cooperativity switch driven by synergistic structural swelling of an osmo-regulatory protein pair |
| title_full | A binding cooperativity switch driven by synergistic structural swelling of an osmo-regulatory protein pair |
| title_fullStr | A binding cooperativity switch driven by synergistic structural swelling of an osmo-regulatory protein pair |
| title_full_unstemmed | A binding cooperativity switch driven by synergistic structural swelling of an osmo-regulatory protein pair |
| title_short | A binding cooperativity switch driven by synergistic structural swelling of an osmo-regulatory protein pair |
| title_sort | binding cooperativity switch driven by synergistic structural swelling of an osmo regulatory protein pair |
| url | https://doi.org/10.1038/s41467-019-10002-9 |
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