Systemic Oxidative Stress and Visceral Adipose Tissue Mediators of NLRP3 Inflammasome and Autophagy Are Reduced in Obese Type 2 Diabetic Patients Treated with Metformin

Systemic Oxidative Stress and Visceral Adipose Tissue Mediators of NLRP3 Inflammasome and Autophagy Are Reduced in Obese Type 2 Diabetic Patients Treated with Metformin

Obesity is a low-grade inflammatory condition affecting a range of individuals, from metabolically healthy obese (MHO) subjects to type 2 diabetes (T2D) patients. Metformin has been shown to display anti-inflammatory properties, though the underlying molecular mechanisms are unclear. To study whethe...

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Bibliographic Details
Main Authors: Zaida Abad-Jiménez, Sandra López-Domènech, Rubén Díaz-Rúa, Francesca Iannantuoni, Segundo Ángel Gómez-Abril, Dolores Periañez-Gómez, Carlos Morillas, Víctor M. Víctor, Milagros Rocha
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Antioxidants
Subjects:
visceral adipose tissue (VAT)
obesity
type 2 diabetes (T2D)
inflammatory cytokines
autophagy
oxidative stress
Online Access:https://www.mdpi.com/2076-3921/9/9/892

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