Serum Folate Related to Five Measurements of Obesity and High-Sensitivity C-Reactive Protein in Korean Adults
This study investigated the effects of folic acid on obesity and high-sensitivity C-reactive protein (CRP) levels. Using data from the Korea National Health and Nutrition Examination Survey (KNHANES VII 2016–2018), 6394 adults (aged 19–80 years) who met the study criteria were identified and divided...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/14/17/3461 |
| _version_ | 1797493874087690240 |
|---|---|
| author | Mee-Ri Lee Sung Min Jung |
| author_facet | Mee-Ri Lee Sung Min Jung |
| author_sort | Mee-Ri Lee |
| collection | DOAJ |
| description | This study investigated the effects of folic acid on obesity and high-sensitivity C-reactive protein (CRP) levels. Using data from the Korea National Health and Nutrition Examination Survey (KNHANES VII 2016–2018), 6394 adults (aged 19–80 years) who met the study criteria were identified and divided into young, middle-aged, and older adult groups. The analysis assessed associations using logistic regression for complex samples. Obesity was measured using body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), a body shape index (ABSI), and body roundness index (BRI). The odds ratio (OR) of obesity based on BMI were statistically significant for young adults and older participants with low levels of folic acid compared to those with high levels (OR: 1.33 and 1.58, respectively). The OR of obesity based on BMI, WC, WHtR, ABSI, and BRI was significant with low levels of folic acid in middle-aged individuals (OR: 1.36, 1.32, 1.41, 1.29, and 1.47, respectively). Low folate levels were related to higher high-sensitivity CRP levels in middle-aged patients. In conclusion, folate level showed a significant inverse association with obesity and inflammatory biomarkers, especially in the middle-aged group. Further longitudinal or randomized controlled trials are needed to confirm and expand our results. |
| first_indexed | 2024-03-10T01:26:14Z |
| format | Article |
| id | doaj.art-c5f43cca5622405b856189fff1eae2ec |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T01:26:14Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-c5f43cca5622405b856189fff1eae2ec2023-11-23T13:50:48ZengMDPI AGNutrients2072-66432022-08-011417346110.3390/nu14173461Serum Folate Related to Five Measurements of Obesity and High-Sensitivity C-Reactive Protein in Korean AdultsMee-Ri Lee0Sung Min Jung1Department of Preventive Medicine, Soonchunhyang University College of Medicine, Cheonan-si 31151, KoreaDepartment of Surgery, Inje University, Ilsan Paik Hospital, Goyang-si 10380, KoreaThis study investigated the effects of folic acid on obesity and high-sensitivity C-reactive protein (CRP) levels. Using data from the Korea National Health and Nutrition Examination Survey (KNHANES VII 2016–2018), 6394 adults (aged 19–80 years) who met the study criteria were identified and divided into young, middle-aged, and older adult groups. The analysis assessed associations using logistic regression for complex samples. Obesity was measured using body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), a body shape index (ABSI), and body roundness index (BRI). The odds ratio (OR) of obesity based on BMI were statistically significant for young adults and older participants with low levels of folic acid compared to those with high levels (OR: 1.33 and 1.58, respectively). The OR of obesity based on BMI, WC, WHtR, ABSI, and BRI was significant with low levels of folic acid in middle-aged individuals (OR: 1.36, 1.32, 1.41, 1.29, and 1.47, respectively). Low folate levels were related to higher high-sensitivity CRP levels in middle-aged patients. In conclusion, folate level showed a significant inverse association with obesity and inflammatory biomarkers, especially in the middle-aged group. Further longitudinal or randomized controlled trials are needed to confirm and expand our results.https://www.mdpi.com/2072-6643/14/17/3461folic acidbody mass indexwaist–height ratiowaist circumferencea body shape indexbody roundness index |
| spellingShingle | Mee-Ri Lee Sung Min Jung Serum Folate Related to Five Measurements of Obesity and High-Sensitivity C-Reactive Protein in Korean Adults Nutrients folic acid body mass index waist–height ratio waist circumference a body shape index body roundness index |
| title | Serum Folate Related to Five Measurements of Obesity and High-Sensitivity C-Reactive Protein in Korean Adults |
| title_full | Serum Folate Related to Five Measurements of Obesity and High-Sensitivity C-Reactive Protein in Korean Adults |
| title_fullStr | Serum Folate Related to Five Measurements of Obesity and High-Sensitivity C-Reactive Protein in Korean Adults |
| title_full_unstemmed | Serum Folate Related to Five Measurements of Obesity and High-Sensitivity C-Reactive Protein in Korean Adults |
| title_short | Serum Folate Related to Five Measurements of Obesity and High-Sensitivity C-Reactive Protein in Korean Adults |
| title_sort | serum folate related to five measurements of obesity and high sensitivity c reactive protein in korean adults |
| topic | folic acid body mass index waist–height ratio waist circumference a body shape index body roundness index |
| url | https://www.mdpi.com/2072-6643/14/17/3461 |
| work_keys_str_mv | AT meerilee serumfolaterelatedtofivemeasurementsofobesityandhighsensitivitycreactiveproteininkoreanadults AT sungminjung serumfolaterelatedtofivemeasurementsofobesityandhighsensitivitycreactiveproteininkoreanadults |