Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study
Abstract Background Numerous studies have concentrated on high-dose radiation exposed accidentally or through therapy, and few involve low-dose occupational exposure, to investigate the correlation between low-dose ionizing radiation and changing hematological parameters among medical workers. Metho...
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| Format: | Article |
| Language: | English |
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Komiyama Printing Co. Ltd
2021-01-01
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| Series: | Environmental Health and Preventive Medicine |
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| Online Access: | https://doi.org/10.1186/s12199-021-00939-z |
| _version_ | 1818015723184717824 |
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| author | Ning Liu Yang Peng Xinguang Zhong Zheng Ma Suiping He Ying Li Wencui Zhang Zijun Gong Zhenjiang Yao |
| author_facet | Ning Liu Yang Peng Xinguang Zhong Zheng Ma Suiping He Ying Li Wencui Zhang Zijun Gong Zhenjiang Yao |
| author_sort | Ning Liu |
| collection | DOAJ |
| description | Abstract Background Numerous studies have concentrated on high-dose radiation exposed accidentally or through therapy, and few involve low-dose occupational exposure, to investigate the correlation between low-dose ionizing radiation and changing hematological parameters among medical workers. Methods Using a prospective cohort study design, we collected health examination reports and personal dose monitoring data from medical workers and used Poisson regression and restricted cubic spline models to assess the correlation between changing hematological parameters and cumulative radiation dose and determine the dose-response relationship. Results We observed that changing platelet of 1265 medical workers followed up was statistically different among the cumulative dose groups (P = 0.010). Although the linear trend tested was not statistically significant (P trend = 0.258), the non-linear trend tested was statistically significant (P non-linear = 0.007). Overall, there was a correlation between changing platelets and cumulative radiation dose (a change of βa 0.008 × 109/L during biennially after adjusting for gender, age at baseline, service at baseline, occupation, medical level, and smoking habits; 95% confidence interval [CI] = 0.003,0.014 × 109/L). Moreover, we also found positive first and then negative dose-response relationships between cumulative radiation dose and changing platelets by restricted cubic spline models, while there were negative patterns of the baseline service not less than 10 years (− 0.015 × 109/L, 95% CI = − 0.024, − 0.007 × 109/L) and radiation nurses(− 0.033 × 109/L, 95% CI = − 0.049, − 0.016 × 109/L). Conclusion We concluded that although the exposure dose was below the limit, medical workers exposed to low-dose ionizing radiation for a short period of time might have increased first and then decreased platelets, and there was a dose-response relationship between the cumulative radiation dose and platelets changing. |
| first_indexed | 2024-04-14T07:01:46Z |
| format | Article |
| id | doaj.art-c5f5c6a5e6314eb1bac3e99d5d5978f9 |
| institution | Directory Open Access Journal |
| issn | 1342-078X 1347-4715 |
| language | English |
| last_indexed | 2024-04-14T07:01:46Z |
| publishDate | 2021-01-01 |
| publisher | Komiyama Printing Co. Ltd |
| record_format | Article |
| series | Environmental Health and Preventive Medicine |
| spelling | doaj.art-c5f5c6a5e6314eb1bac3e99d5d5978f92022-12-22T02:06:45ZengKomiyama Printing Co. LtdEnvironmental Health and Preventive Medicine1342-078X1347-47152021-01-0126111010.1186/s12199-021-00939-zEffects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort studyNing Liu0Yang Peng1Xinguang Zhong2Zheng Ma3Suiping He4Ying Li5Wencui Zhang6Zijun Gong7Zhenjiang Yao8Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Pharmaceutical UniversityCancer Research Centre, Cancer Council QueenslandThe Sixth People’s Hospital of DongguanThe Sixth People’s Hospital of DongguanDepartment of Epidemiology and Health Statistics, School of Public Health, Guangdong Pharmaceutical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Guangdong Pharmaceutical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Guangdong Pharmaceutical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Guangdong Pharmaceutical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Guangdong Pharmaceutical UniversityAbstract Background Numerous studies have concentrated on high-dose radiation exposed accidentally or through therapy, and few involve low-dose occupational exposure, to investigate the correlation between low-dose ionizing radiation and changing hematological parameters among medical workers. Methods Using a prospective cohort study design, we collected health examination reports and personal dose monitoring data from medical workers and used Poisson regression and restricted cubic spline models to assess the correlation between changing hematological parameters and cumulative radiation dose and determine the dose-response relationship. Results We observed that changing platelet of 1265 medical workers followed up was statistically different among the cumulative dose groups (P = 0.010). Although the linear trend tested was not statistically significant (P trend = 0.258), the non-linear trend tested was statistically significant (P non-linear = 0.007). Overall, there was a correlation between changing platelets and cumulative radiation dose (a change of βa 0.008 × 109/L during biennially after adjusting for gender, age at baseline, service at baseline, occupation, medical level, and smoking habits; 95% confidence interval [CI] = 0.003,0.014 × 109/L). Moreover, we also found positive first and then negative dose-response relationships between cumulative radiation dose and changing platelets by restricted cubic spline models, while there were negative patterns of the baseline service not less than 10 years (− 0.015 × 109/L, 95% CI = − 0.024, − 0.007 × 109/L) and radiation nurses(− 0.033 × 109/L, 95% CI = − 0.049, − 0.016 × 109/L). Conclusion We concluded that although the exposure dose was below the limit, medical workers exposed to low-dose ionizing radiation for a short period of time might have increased first and then decreased platelets, and there was a dose-response relationship between the cumulative radiation dose and platelets changing.https://doi.org/10.1186/s12199-021-00939-zLow-dose ionizing radiationOccupation exposureHematologicalPlatelets |
| spellingShingle | Ning Liu Yang Peng Xinguang Zhong Zheng Ma Suiping He Ying Li Wencui Zhang Zijun Gong Zhenjiang Yao Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study Environmental Health and Preventive Medicine Low-dose ionizing radiation Occupation exposure Hematological Platelets |
| title | Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study |
| title_full | Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study |
| title_fullStr | Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study |
| title_full_unstemmed | Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study |
| title_short | Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study |
| title_sort | effects of exposure to low dose ionizing radiation on changing platelets a prospective cohort study |
| topic | Low-dose ionizing radiation Occupation exposure Hematological Platelets |
| url | https://doi.org/10.1186/s12199-021-00939-z |
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