GLP-1 and Underlying Beneficial Actions in Alzheimer’s Disease, Hypertension, and NASH

GLP-1 and Underlying Beneficial Actions in Alzheimer’s Disease, Hypertension, and NASH

GLP-1 is derived from intestinal L cells, which takes effect through binding to GLP-1R and is inactivated by the enzyme dipeptidyl peptidase-4 (DPP-4). Since its discovery, GLP-1 has emerged as an incretin hormone for its facilitation in insulin release and reduction of insulin resistance (IR). Howe...

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Bibliographic Details
Main Authors: Qiu-Xuan Li, Han Gao, Yue-Xin Guo, Bo-Ya Wang, Rong-xuan Hua, Lei Gao, Hong-Wei Shang, Xin Lu, Jing-Dong Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Endocrinology
Subjects:
GLP-1
Alzheimer’s disease
blood pressure
DPP-4
non-alcoholic steatohepatitis
signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.721198/full

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