Current status of herpesvirus identification in the oral cavity of HIV-infected children
INTRODUCTION: Some viruses of the Herpesviridae family are frequently the etiologic agents of oral lesions associated with HIV. The aim of this study was to identify the presence of herpes simplex virus types 1 and 2 (HSV-1, HSV-2), Varicella Zoster virus (VZV), Epstein-Barr virus (EBV), human...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2013-01-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000100015&lng=en&tlng=en |
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| author | Raquel dos Santos Pinheiro Dennis de Carvalho Ferreira Flávia Nóbrega Norma Suely de Oliveira Santos Ivete Pomarico Ribeiro de Souza Gloria Fernanda Barbosa de Araujo Castro |
| author_facet | Raquel dos Santos Pinheiro Dennis de Carvalho Ferreira Flávia Nóbrega Norma Suely de Oliveira Santos Ivete Pomarico Ribeiro de Souza Gloria Fernanda Barbosa de Araujo Castro |
| author_sort | Raquel dos Santos Pinheiro |
| collection | DOAJ |
| description | INTRODUCTION: Some viruses of the Herpesviridae family are frequently the etiologic agents of oral lesions associated with HIV. The aim of this study was to identify the presence of herpes simplex virus types 1 and 2 (HSV-1, HSV-2), Varicella Zoster virus (VZV), Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), human herpesvirus type 6, type 7 and type 8 (HHV-6, HHV-7 and HHV-8) in the oral cavity of HIV-infected children/adolescents and verify the association between viral subtypes and clinical factors. METHODS: The cells of oral mucosa were collected from 50 HIV infected children/adolescents, 3-13 years old (mean age 8.66). The majority (66%) of selected were girls, and they were all outpatients at the pediatric AIDS clinic of a public hospital in Rio de Janeiro. Nested-PCR was used to identify the viral types. RESULTS: Absence of immunosuppression was observed in 66% of the children. Highly active antiretroviral therapy (HAART) was used by 72.1% of selected and moderate viral load was observed in 56% of the children/adolescents. Viral types were found in 86% of the children and the subtypes were: HSV-1 (4%), HSV-2 (2%), VZV (4%), EBV (0%), HCMV (24%), HHV6 (18%), HHV-7 (68%), HHV8 (0%). CONCLUSIONS: The use of HAART has helped to reduce oral lesions, especially with herpes virus infections. The health professionals who work with these patients should be aware of such lesions because of their predictive value and the herpes virus can be found circulating in the oral cavity without causing lesions. |
| first_indexed | 2024-12-11T18:16:37Z |
| format | Article |
| id | doaj.art-c5f658fd69b342bf88389df6c3197452 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-12-11T18:16:37Z |
| publishDate | 2013-01-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-c5f658fd69b342bf88389df6c31974522022-12-22T00:55:24ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492013-01-01461151910.1590/0037-868217172013S0037-86822013000100015Current status of herpesvirus identification in the oral cavity of HIV-infected childrenRaquel dos Santos PinheiroDennis de Carvalho FerreiraFlávia NóbregaNorma Suely de Oliveira SantosIvete Pomarico Ribeiro de SouzaGloria Fernanda Barbosa de Araujo CastroINTRODUCTION: Some viruses of the Herpesviridae family are frequently the etiologic agents of oral lesions associated with HIV. The aim of this study was to identify the presence of herpes simplex virus types 1 and 2 (HSV-1, HSV-2), Varicella Zoster virus (VZV), Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), human herpesvirus type 6, type 7 and type 8 (HHV-6, HHV-7 and HHV-8) in the oral cavity of HIV-infected children/adolescents and verify the association between viral subtypes and clinical factors. METHODS: The cells of oral mucosa were collected from 50 HIV infected children/adolescents, 3-13 years old (mean age 8.66). The majority (66%) of selected were girls, and they were all outpatients at the pediatric AIDS clinic of a public hospital in Rio de Janeiro. Nested-PCR was used to identify the viral types. RESULTS: Absence of immunosuppression was observed in 66% of the children. Highly active antiretroviral therapy (HAART) was used by 72.1% of selected and moderate viral load was observed in 56% of the children/adolescents. Viral types were found in 86% of the children and the subtypes were: HSV-1 (4%), HSV-2 (2%), VZV (4%), EBV (0%), HCMV (24%), HHV6 (18%), HHV-7 (68%), HHV8 (0%). CONCLUSIONS: The use of HAART has helped to reduce oral lesions, especially with herpes virus infections. The health professionals who work with these patients should be aware of such lesions because of their predictive value and the herpes virus can be found circulating in the oral cavity without causing lesions.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000100015&lng=en&tlng=enHerpesvirusPolymerase chain reactionHuman immunodeficiency virus |
| spellingShingle | Raquel dos Santos Pinheiro Dennis de Carvalho Ferreira Flávia Nóbrega Norma Suely de Oliveira Santos Ivete Pomarico Ribeiro de Souza Gloria Fernanda Barbosa de Araujo Castro Current status of herpesvirus identification in the oral cavity of HIV-infected children Revista da Sociedade Brasileira de Medicina Tropical Herpesvirus Polymerase chain reaction Human immunodeficiency virus |
| title | Current status of herpesvirus identification in the oral cavity of HIV-infected children |
| title_full | Current status of herpesvirus identification in the oral cavity of HIV-infected children |
| title_fullStr | Current status of herpesvirus identification in the oral cavity of HIV-infected children |
| title_full_unstemmed | Current status of herpesvirus identification in the oral cavity of HIV-infected children |
| title_short | Current status of herpesvirus identification in the oral cavity of HIV-infected children |
| title_sort | current status of herpesvirus identification in the oral cavity of hiv infected children |
| topic | Herpesvirus Polymerase chain reaction Human immunodeficiency virus |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000100015&lng=en&tlng=en |
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