The Anti-Cancer Effects of Mitochondrial-Targeted Triphenylphosphonium–Resveratrol Conjugate on Breast Cancer Cells

The Anti-Cancer Effects of Mitochondrial-Targeted Triphenylphosphonium–Resveratrol Conjugate on Breast Cancer Cells

Breast cancer is the most commonly diagnosed cancer in women. Resveratrol, a naturally occurring phytochemical, shows great promise in developing novel anti-cancer therapies. This study hypothesized that the mitochondria-targeted delivery of resveratrol would increase its potency and induce mitochon...

Full description

Bibliographic Details
Main Authors:	Lingling Jiang, Han Yu, Chenwei Wang, Fujin He, Zhongqi Shi, Haohong Tu, Na Ning, Shaofeng Duan, Yunqi Zhao
Format:	Article
Language:	English
Published:	MDPI AG 2022-10-01
Series:	Pharmaceuticals
Subjects:	mitochondrial targeting triphenylphosphonium resveratrol breast cancer metabolomics
Online Access:	https://www.mdpi.com/1424-8247/15/10/1271

Similar Items

Enhanced Subcellular Trafficking of Resveratrol Using Mitochondriotropic Liposomes in Cancer Cells
by: Ji Hee Kang, et al.
Published: (2019-08-01)

Self-Assembled Triphenylphosphonium-Conjugated Dicyanostilbene Nanoparticles and Their Fluorescence Probes for Reactive Oxygen Species
by: Wonjin Choi, et al.
Published: (2018-12-01)

Mitochondria-targeted triphenylphosphonium-based compounds do not affect estrogen receptor α
by: Ludmila A. Zinovkina, et al.
Published: (2020-03-01)

Triphenylphosphonium-Functionalized Gold Nanorod/Zinc Oxide Core–Shell Nanocomposites for Mitochondrial-Targeted Phototherapy
by: Ara Joe, et al.
Published: (2024-02-01)

Linking triphenylphosphonium cation to a bicyclic hydroquinone improves their antiplatelet effect via the regulation of mitochondrial function
by: Diego Méndez, et al.
Published: (2024-06-01)

In Vitro Effect of Mitochondria-Targeted Triphenylphosphonium-Based Compounds (Honokiol, Lonidamine, and Atovaquone) on the Platelet Function and Cytotoxic Activity
by: Héctor Montecino-Garrido, et al.
Published: (2022-05-01)

Design, Synthesis and Preliminary Evaluation of the Cytotoxicity and Antibacterial Activity of Novel Triphenylphosphonium Derivatives of Betulin
by: Mirosława Grymel, et al.
Published: (2022-08-01)

Puerarin-Loaded Liposomes Co-Modified by Ischemic Myocardium-Targeting Peptide and Triphenylphosphonium Cations Ameliorate Myocardial Ischemia-Reperfusion Injury
by: Wang Y, et al.
Published: (2024-08-01)

Mitochondrial Delivery of Phenol Substructure Triggers Mitochondrial Depolarization and Apoptosis of Cancer Cells
by: Elena Gazzano, et al.
Published: (2018-06-01)

Phytopathogenic Fungicidal Activity and Mechanism Approach of Three Kinds of Triphenylphosphonium Salts
by: Xuelian Liu, et al.
Published: (2024-06-01)

A new triphenylphosphonium-conjugated amphipathic cationic peptide with improved cell-penetrating and ROS-targeting properties
by: Rezeda A. Ishkaeva, et al.
Published: (2023-01-01)

A Triphenylphosphonium-Functionalized Mitochondriotropic Nanocarrier for Efficient Co-Delivery of Doxorubicin and Chloroquine and Enhanced Antineoplastic Activity
by: Katerina N. Panagiotaki, et al.
Published: (2017-11-01)

The Radioprotective Activity of Resveratrol—Metabolomic Point of View
by: Michalina Gramatyka
Published: (2022-05-01)

Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and targeted therapies
by: Balaraman Kalyanaraman, et al.
Published: (2018-05-01)

Beyond the TPP+ "gold standard": a new generation mitochondrial delivery vector based on extended PN frameworks
by: Ong, How Chee, et al.
Published: (2023)

Tumor Targeting Effect of Triphenylphosphonium Cations and Folic Acid Coated with Zr-89-Labeled Silica Nanoparticles
by: Gun Gyun Kim, et al.
Published: (2020-06-01)

The Use of Triphenyl Phosphonium Cation Enhances the Mitochondrial Antiplatelet Effect of the Compound Magnolol
by: Francisca Tellería, et al.
Published: (2023-01-01)

First Report on Cationic Triphenylphosphonium Compounds as Mitochondriotropic H<sub>3</sub>R Ligands with Antioxidant Properties
by: Tobias Werner, et al.
Published: (2024-11-01)

Resveratrol enhances post-injury muscle regeneration by regulating antioxidant and mitochondrial biogenesis
by: Xiaoli Qin, et al.
Published: (2025-01-01)

Design, Synthesis, Biological Evaluation, and Preliminary Mechanistic Study of a Novel Mitochondrial-Targeted Xanthone
by: Sibei Wang, et al.
Published: (2023-01-01)

Mitochondrial-Targeted Triphenylphosphonium–Hydroxycamptothecin Conjugate and Its Nano-Formulations for Breast Cancer Therapy: In Vitro and In Vivo Investigation
by: Kunfeng Zhang, et al.
Published: (2023-01-01)

Resveratrol impinges on retrograde communication without inducing mitochondrial biogenesis in aged rat soleus muscle
by: Rosa Di Lorenzo, et al.
Published: (2024-09-01)

Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions
by: Lolita Kursvietiene, et al.
Published: (2023-11-01)

Complex Mitochondrial Dysfunction Induced by TPP<sup>+</sup>-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells
by: Sebastián Fuentes-Retamal, et al.
Published: (2020-02-01)

Resveratrol inhibits HeLa cell proliferation by regulating mitochondrial function
by: Yuming Zhang, et al.
Published: (2022-08-01)

Resveratrol combats chronic diseases through enhancing mitochondrial quality
by: Weichu Tao, et al.
Published: (2024-03-01)

Inhibitory Effects of Resveratrol against Mitochondrial Toxicity Induced by Perfluorooctanoic Acid in Isolated Liver Mitochondria of Male Rats
by: Maloos Naderi, et al.
Published: (2022-08-01)

Identification and physiological activity of (methoxymethyl)triphenylphosphonium chloride as a new phytotoxin isolated from Rhizoctonia solani AG-3 TB
by: Xinchun Li, et al.
Published: (2023-11-01)

Alteration of the Mitochondrial Effects of Ceria Nanoparticles by Gold: An Approach for the Mitochondrial Modulation of Cells Based on Nanomedicine
by: Patricia Gutiérrez-Carcedo, et al.
Published: (2020-04-01)

Resveratrol attenuated oxidative stress and inflammatory and mitochondrial dysfunction induced by acute ammonia exposure in gibel carp (Carassius gibelio)
by: Liyun Wu, et al.
Published: (2023-02-01)

Resveratrol-Loaded Solid Lipid Nanoparticle Supplementation Ameliorates Physical Fatigue by Improving Mitochondrial Quality Control
by: Jingyu Sun, et al.
Published: (2019-10-01)

Research Progress on the Regulation of Resveratrol on Alzheimer’s Disease
by: WU Liangwen, ZHANG Hu, WU Tong, CHEN Ning
Published: (2023-02-01)

Effects of Resveratrol on Redox Status, Jejunal Injury, and Mitochondrial Function in Intrauterine Growth-Retarded Weaned Piglets
by: Kang Cheng, et al.
Published: (2025-01-01)

Resveratrol Reestablishes Mitochondrial Quality Control in Myocardial Ischemia/Reperfusion Injury through Sirt1/Sirt3-Mfn2-Parkin-PGC-1α Pathway
by: Minsi Zheng, et al.
Published: (2022-08-01)

Mitochondria-targeted derivative of pterostilbene, a dietary phytoestrogen, exhibits superior cancer cell cytotoxicity via mitochondrial superoxide mediated induction of autophagy
by: Mahin K. Ibrahim, et al.
Published: (2023-07-01)

Tas2r123-associated mitochondrial organization and neuroplasticity underlying the antidepressant effect of resveratrol
by: Hailong Ge, et al.
Published: (2025-04-01)

Protective effect of resveratrol on mitochondrial biogenesis during hyperoxia-induced brain injury in neonatal pups
by: Menghan Yang, et al.
Published: (2023-04-01)

Resveratrol in health and disease /
by: Aggarwal, Bharat B., 1950-, et al.
Published: (2006)

Modification of a natural diterpene and its antitumor mechanism: Promoting apoptosis, suppressing migration, and inhibiting angiogenesis
by: Yuhui Liu, et al.
Published: (2024-03-01)

Platelet Aggregation, Mitochondrial Function and Morphology in Cold Storage: Impact of Resveratrol and Cytochrome c Supplementation
by: Michael L. Ekaney, et al.
Published: (2022-12-01)