Epigenetic Dysregulation of the <i>Homeobox A5</i> (<i>HOXA5</i>) Gene Associates with Subcutaneous Adipocyte Hypertrophy in Human Obesity

Epigenetic Dysregulation of the <i>Homeobox A5</i> (<i>HOXA5</i>) Gene Associates with Subcutaneous Adipocyte Hypertrophy in Human Obesity

Along with insulin resistance and increased risk of type 2 diabetes (T2D), lean first-degree relatives of T2D subjects (FDR) feature impaired adipogenesis in subcutaneous adipose tissue (SAT) and subcutaneous adipocyte hypertrophy well before diabetes onset. The molecular mechanisms linking these ev...

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Bibliographic Details
Main Authors: Luca Parrillo, Rosa Spinelli, Mattia Costanzo, Pasqualina Florese, Serena Cabaro, Antonella Desiderio, Immacolata Prevenzano, Gregory Alexander Raciti, Ulf Smith, Claudia Miele, Pietro Formisano, Raffaele Napoli, Francesco Beguinot
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cells
Subjects:
DNA methylation
adipose tissue
preadipocyte
obesity
transcription factors
T2D familiarity
Online Access:https://www.mdpi.com/2073-4409/11/4/728

Internet

https://www.mdpi.com/2073-4409/11/4/728

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