Remnant liver function is associated with long-term survival in patients with hepatocellular carcinoma undergoing hepatectomy
Abstract It is important to assess the prognosis and intervene before and after surgery in patients with hepatocellular carcinoma. This study aims to elucidate the association of outcomes and residual liver function after hepatectomy. A total of 176 patients who underwent the initial resection for h...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-42929-x |
| _version_ | 1797452745473523712 |
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| author | Atsushi Miki Yasunaru Sakuma Jun Watanabe Kazuhiro Endo Hideki Sasanuma Takumi Teratani Alan Kawarai Lefor Atsushi Shimizu Joji Kitayama Yoshikazu Yasuda Naohiro Sata |
| author_facet | Atsushi Miki Yasunaru Sakuma Jun Watanabe Kazuhiro Endo Hideki Sasanuma Takumi Teratani Alan Kawarai Lefor Atsushi Shimizu Joji Kitayama Yoshikazu Yasuda Naohiro Sata |
| author_sort | Atsushi Miki |
| collection | DOAJ |
| description | Abstract It is important to assess the prognosis and intervene before and after surgery in patients with hepatocellular carcinoma. This study aims to elucidate the association of outcomes and residual liver function after hepatectomy. A total of 176 patients who underwent the initial resection for hepatocellular carcinoma between January 2011 and March 2021 at Jichi Medical University were included. Hepatic clearance of the remnant liver was measured using 99mTc-galactosyl serum albumin scintigraphy. The log-rank test was used to analyze survival using the Kaplan–Meier method. Hazard ratios (HR) and 95% confidence intervals (CI) for overall survival were calculated using Cox’s proportional hazard model. In multivariate analysis, microvascular invasion, intraoperative blood loss, and hepatic clearance of the remnant liver were independently associated with overall survival. Hepatic clearance of the remnant liver was independently associated with recurrence free survival. This is the first report to show that lower residual liver function is associated with shorter survival in patients with hepatocellular carcinoma undergoing hepatectomy. Preoperative determination of remnant liver function may allow assessment of prognosis in patients planned to undergo resection of hepatocellular carcinoma. Preservation of liver functional reserve may be crucial for improved long-term outcomes after hepatectomy. |
| first_indexed | 2024-03-09T15:13:07Z |
| format | Article |
| id | doaj.art-c5fe3c6dd05b46f9a2f98a3dc69aea94 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:13:07Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-c5fe3c6dd05b46f9a2f98a3dc69aea942023-11-26T13:17:15ZengNature PortfolioScientific Reports2045-23222023-09-011311810.1038/s41598-023-42929-xRemnant liver function is associated with long-term survival in patients with hepatocellular carcinoma undergoing hepatectomyAtsushi Miki0Yasunaru Sakuma1Jun Watanabe2Kazuhiro Endo3Hideki Sasanuma4Takumi Teratani5Alan Kawarai Lefor6Atsushi Shimizu7Joji Kitayama8Yoshikazu Yasuda9Naohiro Sata10Division of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical UniversityDivision of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical UniversityDivision of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical UniversityDivision of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical UniversityDivision of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical UniversityDivision of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical UniversityDivision of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical UniversityDivision of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical UniversityDivision of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical UniversityDivision of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical UniversityDivision of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical UniversityAbstract It is important to assess the prognosis and intervene before and after surgery in patients with hepatocellular carcinoma. This study aims to elucidate the association of outcomes and residual liver function after hepatectomy. A total of 176 patients who underwent the initial resection for hepatocellular carcinoma between January 2011 and March 2021 at Jichi Medical University were included. Hepatic clearance of the remnant liver was measured using 99mTc-galactosyl serum albumin scintigraphy. The log-rank test was used to analyze survival using the Kaplan–Meier method. Hazard ratios (HR) and 95% confidence intervals (CI) for overall survival were calculated using Cox’s proportional hazard model. In multivariate analysis, microvascular invasion, intraoperative blood loss, and hepatic clearance of the remnant liver were independently associated with overall survival. Hepatic clearance of the remnant liver was independently associated with recurrence free survival. This is the first report to show that lower residual liver function is associated with shorter survival in patients with hepatocellular carcinoma undergoing hepatectomy. Preoperative determination of remnant liver function may allow assessment of prognosis in patients planned to undergo resection of hepatocellular carcinoma. Preservation of liver functional reserve may be crucial for improved long-term outcomes after hepatectomy.https://doi.org/10.1038/s41598-023-42929-x |
| spellingShingle | Atsushi Miki Yasunaru Sakuma Jun Watanabe Kazuhiro Endo Hideki Sasanuma Takumi Teratani Alan Kawarai Lefor Atsushi Shimizu Joji Kitayama Yoshikazu Yasuda Naohiro Sata Remnant liver function is associated with long-term survival in patients with hepatocellular carcinoma undergoing hepatectomy Scientific Reports |
| title | Remnant liver function is associated with long-term survival in patients with hepatocellular carcinoma undergoing hepatectomy |
| title_full | Remnant liver function is associated with long-term survival in patients with hepatocellular carcinoma undergoing hepatectomy |
| title_fullStr | Remnant liver function is associated with long-term survival in patients with hepatocellular carcinoma undergoing hepatectomy |
| title_full_unstemmed | Remnant liver function is associated with long-term survival in patients with hepatocellular carcinoma undergoing hepatectomy |
| title_short | Remnant liver function is associated with long-term survival in patients with hepatocellular carcinoma undergoing hepatectomy |
| title_sort | remnant liver function is associated with long term survival in patients with hepatocellular carcinoma undergoing hepatectomy |
| url | https://doi.org/10.1038/s41598-023-42929-x |
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