Pediatric Diabetic Nephropathy: Novel Insights from microRNAs
Diabetic nephropathy (DN) represents the most common microvascular complication in patients with diabetes. This progressive kidney disease has been recognized as the major cause of end-stage renal disease with higher morbidity and mortality. However, its tangled pathophysiology is still not fully kn...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/4/1447 |
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| author | Francesca Lanzaro Annalisa Barlabà Angelica De Nigris Federica Di Domenico Valentina Verde Emanuele Miraglia del Giudice Anna Di Sessa |
| author_facet | Francesca Lanzaro Annalisa Barlabà Angelica De Nigris Federica Di Domenico Valentina Verde Emanuele Miraglia del Giudice Anna Di Sessa |
| author_sort | Francesca Lanzaro |
| collection | DOAJ |
| description | Diabetic nephropathy (DN) represents the most common microvascular complication in patients with diabetes. This progressive kidney disease has been recognized as the major cause of end-stage renal disease with higher morbidity and mortality. However, its tangled pathophysiology is still not fully known. Due to the serious health burden of DN, novel potential biomarkers have been proposed to improve early identification of the disease. In this complex landscape, several lines of evidence supported a critical role of microRNAs (miRNAs) in regulating posttranscriptional levels of protein-coding genes involved in DN pathophysiology. Indeed, intriguing data showed that deregulation of certain miRNAs (e.g., miRNAs 21, -25, -92, -210, -126, -216, and -377) were pathogenically linked to the onset and the progression of DN, suggesting not only a role as early biomarkers but also as potential therapeutic targets. To date, these regulatory biomolecules represent the most promising diagnostic and therapeutic options for DN in adult patients, while similar pediatric evidence is still limited. More, findings from these elegant studies, although promising, need to be deeper investigated in larger validation studies. In an attempt to provide a comprehensive pediatric overview in the field, we aimed to summarize the most recent evidence on the emerging role of miRNAs in pediatric DN pathophysiology. |
| first_indexed | 2024-03-11T08:37:59Z |
| format | Article |
| id | doaj.art-c6001dfbdcb143059d09f728e57dc388 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T08:37:59Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-c6001dfbdcb143059d09f728e57dc3882023-11-16T21:19:42ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01124144710.3390/jcm12041447Pediatric Diabetic Nephropathy: Novel Insights from microRNAsFrancesca Lanzaro0Annalisa Barlabà1Angelica De Nigris2Federica Di Domenico3Valentina Verde4Emanuele Miraglia del Giudice5Anna Di Sessa6Department of Woman, Child, and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Woman, Child, and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Woman, Child, and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Woman, Child, and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Woman, Child, and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Woman, Child, and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Woman, Child, and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDiabetic nephropathy (DN) represents the most common microvascular complication in patients with diabetes. This progressive kidney disease has been recognized as the major cause of end-stage renal disease with higher morbidity and mortality. However, its tangled pathophysiology is still not fully known. Due to the serious health burden of DN, novel potential biomarkers have been proposed to improve early identification of the disease. In this complex landscape, several lines of evidence supported a critical role of microRNAs (miRNAs) in regulating posttranscriptional levels of protein-coding genes involved in DN pathophysiology. Indeed, intriguing data showed that deregulation of certain miRNAs (e.g., miRNAs 21, -25, -92, -210, -126, -216, and -377) were pathogenically linked to the onset and the progression of DN, suggesting not only a role as early biomarkers but also as potential therapeutic targets. To date, these regulatory biomolecules represent the most promising diagnostic and therapeutic options for DN in adult patients, while similar pediatric evidence is still limited. More, findings from these elegant studies, although promising, need to be deeper investigated in larger validation studies. In an attempt to provide a comprehensive pediatric overview in the field, we aimed to summarize the most recent evidence on the emerging role of miRNAs in pediatric DN pathophysiology.https://www.mdpi.com/2077-0383/12/4/1447diabeticnephropathymicroRNAtreatmentbiomarkerchildren |
| spellingShingle | Francesca Lanzaro Annalisa Barlabà Angelica De Nigris Federica Di Domenico Valentina Verde Emanuele Miraglia del Giudice Anna Di Sessa Pediatric Diabetic Nephropathy: Novel Insights from microRNAs Journal of Clinical Medicine diabetic nephropathy microRNA treatment biomarker children |
| title | Pediatric Diabetic Nephropathy: Novel Insights from microRNAs |
| title_full | Pediatric Diabetic Nephropathy: Novel Insights from microRNAs |
| title_fullStr | Pediatric Diabetic Nephropathy: Novel Insights from microRNAs |
| title_full_unstemmed | Pediatric Diabetic Nephropathy: Novel Insights from microRNAs |
| title_short | Pediatric Diabetic Nephropathy: Novel Insights from microRNAs |
| title_sort | pediatric diabetic nephropathy novel insights from micrornas |
| topic | diabetic nephropathy microRNA treatment biomarker children |
| url | https://www.mdpi.com/2077-0383/12/4/1447 |
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