Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death
Summary: Organismal death is a process of systemic collapse whose mechanisms are less well understood than those of cell death. We previously reported that death in C. elegans is accompanied by a calcium-propagated wave of intestinal necrosis, marked by a wave of blue autofluorescence (death fluores...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-03-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124718302316 |
| _version_ | 1818307997325066240 |
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| author | Evgeniy R. Galimov Rosina E. Pryor Sarah E. Poole Alexandre Benedetto Zachary Pincus David Gems |
| author_facet | Evgeniy R. Galimov Rosina E. Pryor Sarah E. Poole Alexandre Benedetto Zachary Pincus David Gems |
| author_sort | Evgeniy R. Galimov |
| collection | DOAJ |
| description | Summary: Organismal death is a process of systemic collapse whose mechanisms are less well understood than those of cell death. We previously reported that death in C. elegans is accompanied by a calcium-propagated wave of intestinal necrosis, marked by a wave of blue autofluorescence (death fluorescence). Here, we describe another feature of organismal death, a wave of body wall muscle contraction, or death contraction (DC). This phenomenon is accompanied by a wave of intramuscular Ca2+ release and, subsequently, of intestinal necrosis. Correlation of directions of the DC and intestinal necrosis waves implies coupling of these death processes. Long-lived insulin/IGF-1-signaling mutants show reduced DC and delayed intestinal necrosis, suggesting possible resistance to organismal death. DC resembles mammalian rigor mortis, a postmortem necrosis-related process in which Ca2+ influx promotes muscle hyper-contraction. In contrast to mammals, DC is an early rather than a late event in C. elegans organismal death. Video Abstract: : Galimov et al. describe mechanisms of organismal death in C. elegans. They document a rigor mortis-like wave of muscle hyper-contraction accompanied by Ca2+ release and falling ATP, which is coupled to the previously described wave of intestinal necrosis in a process that resembles a distorted and deadly defecation cycle. Keywords: aging, ATP, calcium, C. elegans, muscle, necrosis, organismal death, pathology, rigor mortis |
| first_indexed | 2024-12-13T07:07:16Z |
| format | Article |
| id | doaj.art-c600758ff81a4a5a8801f350cb0c9c7b |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-13T07:07:16Z |
| publishDate | 2018-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-c600758ff81a4a5a8801f350cb0c9c7b2022-12-21T23:55:47ZengElsevierCell Reports2211-12472018-03-01221027302741Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal DeathEvgeniy R. Galimov0Rosina E. Pryor1Sarah E. Poole2Alexandre Benedetto3Zachary Pincus4David Gems5Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, London, UKInstitute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, London, UKInstitute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, London, UKInstitute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, London, UK; Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YW, UKDepartment of Genetics and Department of Developmental Biology, Washington University in St. Louis, St. Louis, MO 63110, USAInstitute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, London, UK; Corresponding authorSummary: Organismal death is a process of systemic collapse whose mechanisms are less well understood than those of cell death. We previously reported that death in C. elegans is accompanied by a calcium-propagated wave of intestinal necrosis, marked by a wave of blue autofluorescence (death fluorescence). Here, we describe another feature of organismal death, a wave of body wall muscle contraction, or death contraction (DC). This phenomenon is accompanied by a wave of intramuscular Ca2+ release and, subsequently, of intestinal necrosis. Correlation of directions of the DC and intestinal necrosis waves implies coupling of these death processes. Long-lived insulin/IGF-1-signaling mutants show reduced DC and delayed intestinal necrosis, suggesting possible resistance to organismal death. DC resembles mammalian rigor mortis, a postmortem necrosis-related process in which Ca2+ influx promotes muscle hyper-contraction. In contrast to mammals, DC is an early rather than a late event in C. elegans organismal death. Video Abstract: : Galimov et al. describe mechanisms of organismal death in C. elegans. They document a rigor mortis-like wave of muscle hyper-contraction accompanied by Ca2+ release and falling ATP, which is coupled to the previously described wave of intestinal necrosis in a process that resembles a distorted and deadly defecation cycle. Keywords: aging, ATP, calcium, C. elegans, muscle, necrosis, organismal death, pathology, rigor mortishttp://www.sciencedirect.com/science/article/pii/S2211124718302316 |
| spellingShingle | Evgeniy R. Galimov Rosina E. Pryor Sarah E. Poole Alexandre Benedetto Zachary Pincus David Gems Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death Cell Reports |
| title | Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death |
| title_full | Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death |
| title_fullStr | Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death |
| title_full_unstemmed | Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death |
| title_short | Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death |
| title_sort | coupling of rigor mortis and intestinal necrosis during c elegans organismal death |
| url | http://www.sciencedirect.com/science/article/pii/S2211124718302316 |
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