LOX-1 mediates inflammatory activation of microglial cells through the p38-MAPK/NF-κB pathways under hypoxic-ischemic conditions

LOX-1 mediates inflammatory activation of microglial cells through the p38-MAPK/NF-κB pathways under hypoxic-ischemic conditions

Abstract Background Microglial cells play an important role in the immune system in the brain. Activated microglial cells are not only injurious but also neuroprotective. We confirmed marked lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) expression in microglial cells in pathologica...

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Bibliographic Details
Main Authors: Yoshinori Aoki, Hongmei Dai, Fumika Furuta, Tomohisa Akamatsu, Takuya Oshima, Naoto Takahashi, Yu-ichi Goto, Akira Oka, Masayuki Itoh
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Cell Communication and Signaling
Subjects:
Hypoxia
Ischemia
Microglia
p38-MAPK
NF‐kappa B (NF‐κB)
OLR-1
Online Access:https://doi.org/10.1186/s12964-023-01048-w

Internet

https://doi.org/10.1186/s12964-023-01048-w

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