Prolonged and biphasic acute hepatitis A in hepatitis B virus carrier
Acute hepatitis A is generally a self-limited disease in healthy subjects within few weeks, but an uncommon type of prolonged and biphasic acute course of hepatitis A infection has been also described. This type of presentation is observed in about 6-10% of patients, but a small number of reports, c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2016-04-01
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| Series: | Italian Journal of Medicine |
| Subjects: | |
| Online Access: | http://www.italjmed.org/index.php/ijm/article/view/571 |
| _version_ | 1797429444547182592 |
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| author | Elena Garlatti Costa Michela Ghersetti Silvia Grazioli Pietro Casarin |
| author_facet | Elena Garlatti Costa Michela Ghersetti Silvia Grazioli Pietro Casarin |
| author_sort | Elena Garlatti Costa |
| collection | DOAJ |
| description | Acute hepatitis A is generally a self-limited disease in healthy subjects within few weeks, but an uncommon type of prolonged and biphasic acute course of hepatitis A infection has been also described. This type of presentation is observed in about 6-10% of patients, but a small number of reports, concerning this topic, are available in literature. In addition, hepatitis A virus (HAV) infection in hepatitis B virus (HBV) carriers has rarely been discussed. A 41-year-old Italian man, already known to our Department for HBV infection as an inactive carrier HBsAg(+)ve, experienced a prolonged and biphasic course of acute hepatitis A, lasting about 7 months. In this patient possible factors, causing the second flare of transaminases, were excluded (in particular autoimmunity). Liver biopsy as well HAV RNA search in blood/stools were not performed. In conclusion, the hepatologist should take into account this type of atypical course in patients with HAV-related hepatitis and should promote HAV vaccination in subjects with HBV-chronic hepatitis, to prevent possible life-threatening acute exacerbation of hepatic damage, mainly in HBV-carriers with more severe forms of liver diseases. |
| first_indexed | 2024-03-09T09:13:16Z |
| format | Article |
| id | doaj.art-c6011561f8e244f980edbf36fb883ca7 |
| institution | Directory Open Access Journal |
| issn | 1877-9344 1877-9352 |
| language | English |
| last_indexed | 2024-03-09T09:13:16Z |
| publishDate | 2016-04-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Italian Journal of Medicine |
| spelling | doaj.art-c6011561f8e244f980edbf36fb883ca72023-12-02T08:16:02ZengPAGEPress PublicationsItalian Journal of Medicine1877-93441877-93522016-04-0110324124410.4081/itjm.2016.571544Prolonged and biphasic acute hepatitis A in hepatitis B virus carrierElena Garlatti Costa0Michela Ghersetti1Silvia Grazioli2Pietro Casarin3Department of Internal Medicine, Santa Maria degli Angeli Hospital, PordenoneDepartment of Internal Medicine, Santa Maria degli Angeli Hospital, PordenoneDepartment of Internal Medicine, Santa Maria degli Angeli Hospital, PordenoneDepartment of Internal Medicine, Santa Maria degli Angeli Hospital, PordenoneAcute hepatitis A is generally a self-limited disease in healthy subjects within few weeks, but an uncommon type of prolonged and biphasic acute course of hepatitis A infection has been also described. This type of presentation is observed in about 6-10% of patients, but a small number of reports, concerning this topic, are available in literature. In addition, hepatitis A virus (HAV) infection in hepatitis B virus (HBV) carriers has rarely been discussed. A 41-year-old Italian man, already known to our Department for HBV infection as an inactive carrier HBsAg(+)ve, experienced a prolonged and biphasic course of acute hepatitis A, lasting about 7 months. In this patient possible factors, causing the second flare of transaminases, were excluded (in particular autoimmunity). Liver biopsy as well HAV RNA search in blood/stools were not performed. In conclusion, the hepatologist should take into account this type of atypical course in patients with HAV-related hepatitis and should promote HAV vaccination in subjects with HBV-chronic hepatitis, to prevent possible life-threatening acute exacerbation of hepatic damage, mainly in HBV-carriers with more severe forms of liver diseases.http://www.italjmed.org/index.php/ijm/article/view/571Hepatitis A virushepatitis B virusinactive carrier HBsAg(+)veprolonged and biphasic hepatitis A virus infection/relapsing hepatitis Aantibody. |
| spellingShingle | Elena Garlatti Costa Michela Ghersetti Silvia Grazioli Pietro Casarin Prolonged and biphasic acute hepatitis A in hepatitis B virus carrier Italian Journal of Medicine Hepatitis A virus hepatitis B virus inactive carrier HBsAg(+)ve prolonged and biphasic hepatitis A virus infection/relapsing hepatitis A antibody. |
| title | Prolonged and biphasic acute hepatitis A in hepatitis B virus carrier |
| title_full | Prolonged and biphasic acute hepatitis A in hepatitis B virus carrier |
| title_fullStr | Prolonged and biphasic acute hepatitis A in hepatitis B virus carrier |
| title_full_unstemmed | Prolonged and biphasic acute hepatitis A in hepatitis B virus carrier |
| title_short | Prolonged and biphasic acute hepatitis A in hepatitis B virus carrier |
| title_sort | prolonged and biphasic acute hepatitis a in hepatitis b virus carrier |
| topic | Hepatitis A virus hepatitis B virus inactive carrier HBsAg(+)ve prolonged and biphasic hepatitis A virus infection/relapsing hepatitis A antibody. |
| url | http://www.italjmed.org/index.php/ijm/article/view/571 |
| work_keys_str_mv | AT elenagarlatticosta prolongedandbiphasicacutehepatitisainhepatitisbviruscarrier AT michelaghersetti prolongedandbiphasicacutehepatitisainhepatitisbviruscarrier AT silviagrazioli prolongedandbiphasicacutehepatitisainhepatitisbviruscarrier AT pietrocasarin prolongedandbiphasicacutehepatitisainhepatitisbviruscarrier |