Report of an unsual case of anophthalmia and craniofacial cleft in a newborn with Toxoplasma gondii congenital infection
Abstract Background We present one unusual case of anophthalmia and craniofacial cleft, probably due to congenital toxoplasmosis only. Case presentation A two-month-old male had a twin in utero who disappeared between the 7th and the 14th week of gestation. At birth, the baby presented anophthalmia...
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| Format: | Article |
| Language: | English |
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BMC
2017-07-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://link.springer.com/article/10.1186/s12879-017-2565-8 |
| _version_ | 1819227305090744320 |
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| author | Gabriel Emmanuel Arce-Estrada Valeria Gómez-Toscano Carlos Cedillo-Peláez Ana Luisa Sesman-Bernal Vanessa Bosch-Canto José Luis Mayorga-Butrón José Antonio Vargas-Villavicencio Dolores Correa |
| author_facet | Gabriel Emmanuel Arce-Estrada Valeria Gómez-Toscano Carlos Cedillo-Peláez Ana Luisa Sesman-Bernal Vanessa Bosch-Canto José Luis Mayorga-Butrón José Antonio Vargas-Villavicencio Dolores Correa |
| author_sort | Gabriel Emmanuel Arce-Estrada |
| collection | DOAJ |
| description | Abstract Background We present one unusual case of anophthalmia and craniofacial cleft, probably due to congenital toxoplasmosis only. Case presentation A two-month-old male had a twin in utero who disappeared between the 7th and the 14th week of gestation. At birth, the baby presented anophthalmia and craniofacial cleft, and no sign compatible with genetic or exposition/deficiency problems, like the Wolf-Hirschhorn syndrome or maternal vitamin A deficiency. Congenital toxoplasmosis was confirmed by the presence of IgM abs and IgG neo-antibodies in western blot, as well as by real time PCR in blood. CMV infection was also discarded by PCR and IgM negative results. Structures suggestive of T. gondii pseudocysts were observed in a biopsy taken during the first functional/esthetic surgery. Conclusions We conclude that this is a rare case of anophthalmia combined with craniofacial cleft due to congenital toxoplasmosis, that must be considered by physicians. This has not been reported before. |
| first_indexed | 2024-12-23T10:39:16Z |
| format | Article |
| id | doaj.art-c6027f7b00b64b7ab9e7f1b368ffac08 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-23T10:39:16Z |
| publishDate | 2017-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-c6027f7b00b64b7ab9e7f1b368ffac082022-12-21T17:50:12ZengBMCBMC Infectious Diseases1471-23342017-07-011711510.1186/s12879-017-2565-8Report of an unsual case of anophthalmia and craniofacial cleft in a newborn with Toxoplasma gondii congenital infectionGabriel Emmanuel Arce-Estrada0Valeria Gómez-Toscano1Carlos Cedillo-Peláez2Ana Luisa Sesman-Bernal3Vanessa Bosch-Canto4José Luis Mayorga-Butrón5José Antonio Vargas-Villavicencio6Dolores Correa7Laboratory Inmunología Experimental, Instituto Nacional de Pediatría (INP), Secretaría de Salud, Torre de InvestigaciónLaboratory Inmunología Experimental, Instituto Nacional de Pediatría (INP), Secretaría de Salud, Torre de InvestigaciónLaboratory Inmunología Experimental, Instituto Nacional de Pediatría (INP), Secretaría de Salud, Torre de InvestigaciónServicio de Cirugía Plástica, Instituto Nacional de Pediatría (INP), Secretaría de SaludServicio de Oftalmología, Instituto Nacional de Pediatría (INP), Secretaría de SaludServicio de Otorrinolaringología, Instituto Nacional de Pediatría (INP), Secretaría de SaludLaboratory Inmunología Experimental, Instituto Nacional de Pediatría (INP), Secretaría de Salud, Torre de InvestigaciónLaboratory Inmunología Experimental, Instituto Nacional de Pediatría (INP), Secretaría de Salud, Torre de InvestigaciónAbstract Background We present one unusual case of anophthalmia and craniofacial cleft, probably due to congenital toxoplasmosis only. Case presentation A two-month-old male had a twin in utero who disappeared between the 7th and the 14th week of gestation. At birth, the baby presented anophthalmia and craniofacial cleft, and no sign compatible with genetic or exposition/deficiency problems, like the Wolf-Hirschhorn syndrome or maternal vitamin A deficiency. Congenital toxoplasmosis was confirmed by the presence of IgM abs and IgG neo-antibodies in western blot, as well as by real time PCR in blood. CMV infection was also discarded by PCR and IgM negative results. Structures suggestive of T. gondii pseudocysts were observed in a biopsy taken during the first functional/esthetic surgery. Conclusions We conclude that this is a rare case of anophthalmia combined with craniofacial cleft due to congenital toxoplasmosis, that must be considered by physicians. This has not been reported before.http://link.springer.com/article/10.1186/s12879-017-2565-8AnophthalmiaCongenital toxoplasmosisCraniofacial cleftToxoplasma gondiiCase report |
| spellingShingle | Gabriel Emmanuel Arce-Estrada Valeria Gómez-Toscano Carlos Cedillo-Peláez Ana Luisa Sesman-Bernal Vanessa Bosch-Canto José Luis Mayorga-Butrón José Antonio Vargas-Villavicencio Dolores Correa Report of an unsual case of anophthalmia and craniofacial cleft in a newborn with Toxoplasma gondii congenital infection BMC Infectious Diseases Anophthalmia Congenital toxoplasmosis Craniofacial cleft Toxoplasma gondii Case report |
| title | Report of an unsual case of anophthalmia and craniofacial cleft in a newborn with Toxoplasma gondii congenital infection |
| title_full | Report of an unsual case of anophthalmia and craniofacial cleft in a newborn with Toxoplasma gondii congenital infection |
| title_fullStr | Report of an unsual case of anophthalmia and craniofacial cleft in a newborn with Toxoplasma gondii congenital infection |
| title_full_unstemmed | Report of an unsual case of anophthalmia and craniofacial cleft in a newborn with Toxoplasma gondii congenital infection |
| title_short | Report of an unsual case of anophthalmia and craniofacial cleft in a newborn with Toxoplasma gondii congenital infection |
| title_sort | report of an unsual case of anophthalmia and craniofacial cleft in a newborn with toxoplasma gondii congenital infection |
| topic | Anophthalmia Congenital toxoplasmosis Craniofacial cleft Toxoplasma gondii Case report |
| url | http://link.springer.com/article/10.1186/s12879-017-2565-8 |
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