New Acyclic Cytotoxic Jasplakinolide Derivative from the Marine Sponge <i>Jaspis splendens</i>
A new acylic jasplakinolide congener (<b>2</b>), another acyclic derivative requiring revision (<b>4</b>), together with two jasplakinolide derivatives including the parent compound jasplakinolide (<b>1</b>) were isolated from the Indonesian marine sponge <i>...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-02-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/17/2/100 |
| Summary: | A new acylic jasplakinolide congener (<b>2</b>), another acyclic derivative requiring revision (<b>4</b>), together with two jasplakinolide derivatives including the parent compound jasplakinolide (<b>1</b>) were isolated from the Indonesian marine sponge <i>Jaspis splendens</i>. The chemical structures of the new and known compounds were unambiguously elucidated based on HRESIMS and exhaustive 1D and 2D NMR spectral analysis as well as a comparison of their NMR data with those of jasplakinolide (<b>1</b>). The isolated jasplakinolides inhibited the growth of mouse lymphoma (L5178Y) cells in vitro with IC<sub>50</sub> values in the low micromolar to nanomolar range. |
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| ISSN: | 1660-3397 |