Evaluation of cardioprotective activity of Lepidium sativum seed powder in albino rats treated with 5-fluorouracil
5-fluorouracil (5-FU) is a chemotherapeutic agent used for treatment of solid tumors. Cardiotoxicity is a major complication of 5-FU therapy. Therefore, the aim of the present study was to evaluate the possible cardioprotective potency of Lepidium sativum seed powder (LS) against 5-FU-induced cardio...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2016-06-01
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| Series: | Beni-Suef University Journal of Basic and Applied Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2314853516300154 |
| _version_ | 1818957060518182912 |
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| author | Eman Taha Mohamed Ghada Mohamed Safwat |
| author_facet | Eman Taha Mohamed Ghada Mohamed Safwat |
| author_sort | Eman Taha Mohamed |
| collection | DOAJ |
| description | 5-fluorouracil (5-FU) is a chemotherapeutic agent used for treatment of solid tumors. Cardiotoxicity is a major complication of 5-FU therapy. Therefore, the aim of the present study was to evaluate the possible cardioprotective potency of Lepidium sativum seed powder (LS) against 5-FU-induced cardiotoxicity and oxidative stress in albino rats. The rats were divided into three groups. Rats in the control group received saline daily for 8 days only. Rats in FU-treated group received saline orally for 8 days, then I.P. injected with 5-FU (150 mg\kg B.W) on the 5th day. Rats in LS-treated group were orally dosed with LS (550 mg\kg B.W\day) for 8 days, and on the 5th day rats were administrated with the same previous dose of 5-FU. 5-FU induced cardiotoxicity was assessed by a significant increase in serum concentrations of cTnI, CK-MB, lipid profile and a moderate elevation of cardiac MDA. 5-FU significantly decreased serum HDL-c and GSH concentration in cardiac homogenate. Its administration also resulted in the release of some inflammatory markers such as myeloperoxidase and Interleukin-1β (IL-1β). All 5-FU altered parameters were markedly ameliorated by LS pre-co-post-treatment. Results of the present study suggest that LS has a significant effect on the protection of the heart against 5-FU-induced cardiotoxicity through maintaining the antioxidant and anti-inflammatory activities. |
| first_indexed | 2024-12-20T11:03:51Z |
| format | Article |
| id | doaj.art-c604c34e4c244ea2b4458a180aa79f45 |
| institution | Directory Open Access Journal |
| issn | 2314-8535 |
| language | English |
| last_indexed | 2024-12-20T11:03:51Z |
| publishDate | 2016-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Beni-Suef University Journal of Basic and Applied Sciences |
| spelling | doaj.art-c604c34e4c244ea2b4458a180aa79f452022-12-21T19:42:55ZengSpringerOpenBeni-Suef University Journal of Basic and Applied Sciences2314-85352016-06-015220821510.1016/j.bjbas.2016.05.001Evaluation of cardioprotective activity of Lepidium sativum seed powder in albino rats treated with 5-fluorouracilEman Taha MohamedGhada Mohamed Safwat5-fluorouracil (5-FU) is a chemotherapeutic agent used for treatment of solid tumors. Cardiotoxicity is a major complication of 5-FU therapy. Therefore, the aim of the present study was to evaluate the possible cardioprotective potency of Lepidium sativum seed powder (LS) against 5-FU-induced cardiotoxicity and oxidative stress in albino rats. The rats were divided into three groups. Rats in the control group received saline daily for 8 days only. Rats in FU-treated group received saline orally for 8 days, then I.P. injected with 5-FU (150 mg\kg B.W) on the 5th day. Rats in LS-treated group were orally dosed with LS (550 mg\kg B.W\day) for 8 days, and on the 5th day rats were administrated with the same previous dose of 5-FU. 5-FU induced cardiotoxicity was assessed by a significant increase in serum concentrations of cTnI, CK-MB, lipid profile and a moderate elevation of cardiac MDA. 5-FU significantly decreased serum HDL-c and GSH concentration in cardiac homogenate. Its administration also resulted in the release of some inflammatory markers such as myeloperoxidase and Interleukin-1β (IL-1β). All 5-FU altered parameters were markedly ameliorated by LS pre-co-post-treatment. Results of the present study suggest that LS has a significant effect on the protection of the heart against 5-FU-induced cardiotoxicity through maintaining the antioxidant and anti-inflammatory activities.http://www.sciencedirect.com/science/article/pii/S2314853516300154Lepidium sativum5-fluorouracilTroponinOxidative stressCardiotoxicityRat |
| spellingShingle | Eman Taha Mohamed Ghada Mohamed Safwat Evaluation of cardioprotective activity of Lepidium sativum seed powder in albino rats treated with 5-fluorouracil Beni-Suef University Journal of Basic and Applied Sciences Lepidium sativum 5-fluorouracil Troponin Oxidative stress Cardiotoxicity Rat |
| title | Evaluation of cardioprotective activity of Lepidium sativum seed powder in albino rats treated with 5-fluorouracil |
| title_full | Evaluation of cardioprotective activity of Lepidium sativum seed powder in albino rats treated with 5-fluorouracil |
| title_fullStr | Evaluation of cardioprotective activity of Lepidium sativum seed powder in albino rats treated with 5-fluorouracil |
| title_full_unstemmed | Evaluation of cardioprotective activity of Lepidium sativum seed powder in albino rats treated with 5-fluorouracil |
| title_short | Evaluation of cardioprotective activity of Lepidium sativum seed powder in albino rats treated with 5-fluorouracil |
| title_sort | evaluation of cardioprotective activity of lepidium sativum seed powder in albino rats treated with 5 fluorouracil |
| topic | Lepidium sativum 5-fluorouracil Troponin Oxidative stress Cardiotoxicity Rat |
| url | http://www.sciencedirect.com/science/article/pii/S2314853516300154 |
| work_keys_str_mv | AT emantahamohamed evaluationofcardioprotectiveactivityoflepidiumsativumseedpowderinalbinoratstreatedwith5fluorouracil AT ghadamohamedsafwat evaluationofcardioprotectiveactivityoflepidiumsativumseedpowderinalbinoratstreatedwith5fluorouracil |