Tryptophan metabolism promotes immune evasion in human pancreatic β cellsResearch in context

Tryptophan metabolism promotes immune evasion in human pancreatic β cellsResearch in context

Summary: Background: To resist the autoimmune attack characteristic of type 1 diabetes, insulin producing pancreatic β cells need to evade T-cell recognition. Such escape mechanisms may be conferred by low HLA class I (HLA-I) expression and upregulation of immune inhibitory molecules such as Progra...

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Bibliographic Details
Main Authors: Latif Rachdi, Zhicheng Zhou, Claire Berthault, Chloe Lourenço, Alexis Fouque, Thomas Domet, Mathieu Armanet, Sylvaine You, Mark Peakman, Roberto Mallone, Raphael Scharfmann
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:EBioMedicine
Subjects:
Type 1 diabetes
Islet
Pancreatic beta cells
PD-L1
Tryptophan
HLA-I
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423003055

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