TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo

TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo

Abstract Background Intervertebral disc degeneration (IDD) is one of the most common disorders related to the spine. Inflammation, apoptosis and extracellular matrix (ECM) degradation contribute to disc degeneration in nucleus pulposus cells (NPCs). This study focused on the role and mechanism of th...

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Bibliographic Details
Main Authors: Kun Wang, Dengbo Yao, Yuxi Li, Ming Li, Weike Zeng, Zhuangyao Liao, Engming Chen, Shixin Lu, Kaihui Su, Zhen Che, Yuwei Liang, Peng Wang, Lin Huang
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Arthritis Research & Therapy
Subjects:
TAK-715
Intervertebral disc degeneration
IDD
Inflammation
Apoptosis
p38MAPK
Online Access:https://doi.org/10.1186/s13075-023-03028-4

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