Brain microglia activation and peripheral adaptive immunity in Parkinson’s disease: a multimodal PET study

Brain microglia activation and peripheral adaptive immunity in Parkinson’s disease: a multimodal PET study

Abstract Background Abnormal activation of immune system is an important pathogenesis of Parkinson’s disease, but the relationship between peripheral inflammation, central microglia activation and dopaminergic degeneration remains unclear. Objectives To evaluate the brain regional microglia activati...

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Bibliographic Details
Main Authors: Shu-Ying Liu, Hong-Wen Qiao, Tian-Bin Song, Xiu-Lin Liu, Yun-Xia Yao, Chun-Song Zhao, Olivier Barret, Sheng-Li Xu, Yan-Ning Cai, Gilles D. Tamagnan, Vesna Sossi, Jie Lu, Piu Chan
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Journal of Neuroinflammation
Subjects:
Parkinson’s disease
Microglia
Cytokine
Th cell
Lymphocyte
Positron emission tomograph
Online Access:https://doi.org/10.1186/s12974-022-02574-z

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