Risk of Prediabetes and Diabetes in Oral Lichen Planus: A Case–Control Study according to Current Diagnostic Criteria
Objective: To estimate the prevalence of prediabetes and diabetes in patients with oral lichen planus (OLP). Methods: Prospective cohort, including consecutive patients diagnosed clinically and histologically with OLP from 2018 to 2022. Patients and controls were matched by age and gender. Fasting p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/9/1586 |
| _version_ | 1827743156670562304 |
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| author | Lucía Rodríguez-Fonseca Santiago Llorente-Pendás María García-Pola |
| author_facet | Lucía Rodríguez-Fonseca Santiago Llorente-Pendás María García-Pola |
| author_sort | Lucía Rodríguez-Fonseca |
| collection | DOAJ |
| description | Objective: To estimate the prevalence of prediabetes and diabetes in patients with oral lichen planus (OLP). Methods: Prospective cohort, including consecutive patients diagnosed clinically and histologically with OLP from 2018 to 2022. Patients and controls were matched by age and gender. Fasting plasma glucose value collection from all patients. Multivariate regression analysis evaluated the relationship between prediabetes and diabetes variables according to current diagnostic criteria. Results: The sample comprised 275 patients (207 women; 75.3%), mean age 59.60 ± 12.18 years for both groups. Prediabetes was diagnosed according to the American Diabetes Association (ADA, 100–125 mg/dL), in 21.45% of OLP patients (59/275) and 14.55% (40/275) of control patients (<i>p</i> = 0.035). Patients with the atrophic-erosive form exhibited stronger association with taking oral antidiabetics (<i>p</i> = 0.011). Multivariate analysis showed that being over >60 years and having a cutaneous location was associated with ≥3 sites (OR 1.81 and OR 2.43). ADA prediabetes and oral antidiabetics drugs increased the probability of OLP (OR 1.60 (1.04–2.51), <i>p</i> = 0.03 and OR 2.20 (1.18–4.69), <i>p</i> = 0.017) after adjustment for sex and age. Conclusions: Because glycemia 100–125 mg/dL was associated with OLP, testing serum fasting plasma glucose seems reasonable in order to prevent development of diabetes and deal with possible complications until new studies are complete. |
| first_indexed | 2024-03-11T04:21:32Z |
| format | Article |
| id | doaj.art-c60a2f30bec94c1fbf82375aa7e7eeb9 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T04:21:32Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-c60a2f30bec94c1fbf82375aa7e7eeb92023-11-17T22:45:42ZengMDPI AGDiagnostics2075-44182023-04-01139158610.3390/diagnostics13091586Risk of Prediabetes and Diabetes in Oral Lichen Planus: A Case–Control Study according to Current Diagnostic CriteriaLucía Rodríguez-Fonseca0Santiago Llorente-Pendás1María García-Pola2Department of Surgery and Medical-Surgical Specialties, Faculty of Medicine and Sciences of the Health, Oviedo University, 33006 Oviedo, SpainPrivate Practice, 33004 Oviedo, SpainDepartment of Surgery and Medical-Surgical Specialties, Faculty of Medicine and Sciences of the Health, Oviedo University, 33006 Oviedo, SpainObjective: To estimate the prevalence of prediabetes and diabetes in patients with oral lichen planus (OLP). Methods: Prospective cohort, including consecutive patients diagnosed clinically and histologically with OLP from 2018 to 2022. Patients and controls were matched by age and gender. Fasting plasma glucose value collection from all patients. Multivariate regression analysis evaluated the relationship between prediabetes and diabetes variables according to current diagnostic criteria. Results: The sample comprised 275 patients (207 women; 75.3%), mean age 59.60 ± 12.18 years for both groups. Prediabetes was diagnosed according to the American Diabetes Association (ADA, 100–125 mg/dL), in 21.45% of OLP patients (59/275) and 14.55% (40/275) of control patients (<i>p</i> = 0.035). Patients with the atrophic-erosive form exhibited stronger association with taking oral antidiabetics (<i>p</i> = 0.011). Multivariate analysis showed that being over >60 years and having a cutaneous location was associated with ≥3 sites (OR 1.81 and OR 2.43). ADA prediabetes and oral antidiabetics drugs increased the probability of OLP (OR 1.60 (1.04–2.51), <i>p</i> = 0.03 and OR 2.20 (1.18–4.69), <i>p</i> = 0.017) after adjustment for sex and age. Conclusions: Because glycemia 100–125 mg/dL was associated with OLP, testing serum fasting plasma glucose seems reasonable in order to prevent development of diabetes and deal with possible complications until new studies are complete.https://www.mdpi.com/2075-4418/13/9/1586oral lichen planuslichen planusprediabetesdiabetesoral antidiabeticcomorbidity |
| spellingShingle | Lucía Rodríguez-Fonseca Santiago Llorente-Pendás María García-Pola Risk of Prediabetes and Diabetes in Oral Lichen Planus: A Case–Control Study according to Current Diagnostic Criteria Diagnostics oral lichen planus lichen planus prediabetes diabetes oral antidiabetic comorbidity |
| title | Risk of Prediabetes and Diabetes in Oral Lichen Planus: A Case–Control Study according to Current Diagnostic Criteria |
| title_full | Risk of Prediabetes and Diabetes in Oral Lichen Planus: A Case–Control Study according to Current Diagnostic Criteria |
| title_fullStr | Risk of Prediabetes and Diabetes in Oral Lichen Planus: A Case–Control Study according to Current Diagnostic Criteria |
| title_full_unstemmed | Risk of Prediabetes and Diabetes in Oral Lichen Planus: A Case–Control Study according to Current Diagnostic Criteria |
| title_short | Risk of Prediabetes and Diabetes in Oral Lichen Planus: A Case–Control Study according to Current Diagnostic Criteria |
| title_sort | risk of prediabetes and diabetes in oral lichen planus a case control study according to current diagnostic criteria |
| topic | oral lichen planus lichen planus prediabetes diabetes oral antidiabetic comorbidity |
| url | https://www.mdpi.com/2075-4418/13/9/1586 |
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