Data on the effect of maternal separation coupled with social isolation in a forced swim test and gene expression of glial fibrillary acid protein in the prefrontal cortex of rats
Early life adversity, such as neglect, increases the risk for major depressive disorder and anxiety disorders. It is well-known that astrocytes have key roles in brain function. In this paper, we show the effect of maternal separation (MS) coupled with social isolation on stress response and gene ex...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-06-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340918302609 |
| _version_ | 1818391388285304832 |
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| author | Yosuke Yamawaki Misako Nishida Kana Harada Hiroyuki Akagi |
| author_facet | Yosuke Yamawaki Misako Nishida Kana Harada Hiroyuki Akagi |
| author_sort | Yosuke Yamawaki |
| collection | DOAJ |
| description | Early life adversity, such as neglect, increases the risk for major depressive disorder and anxiety disorders. It is well-known that astrocytes have key roles in brain function. In this paper, we show the effect of maternal separation (MS) coupled with social isolation on stress response and gene expression of glial fibrillary acidic protein (GFAP) as a marker of astrocytes, in early life and adulthood. Stress response was evaluated by using a forced swim test. GFAP gene expression level was evaluated by using the quantitative polymerase chain reaction (qPCR) method. The data in this article provide indexes affected by early life stress. Keywords: Maternal separation, Early life stress, GFAP, qPCR, Forced swim test |
| first_indexed | 2024-12-14T05:12:44Z |
| format | Article |
| id | doaj.art-c60c389ee65f4e76bf0005cfb3a1d439 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-14T05:12:44Z |
| publishDate | 2018-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-c60c389ee65f4e76bf0005cfb3a1d4392022-12-21T23:15:55ZengElsevierData in Brief2352-34092018-06-0118496500Data on the effect of maternal separation coupled with social isolation in a forced swim test and gene expression of glial fibrillary acid protein in the prefrontal cortex of ratsYosuke Yamawaki0Misako Nishida1Kana Harada2Hiroyuki Akagi3Laboratory of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1, Hirokoshingai, Kure, Hiroshima 737-0112, Japan; Department of Cellular and Molecular Pharmacology, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553, Japan; Corresponding author.Laboratory of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1, Hirokoshingai, Kure, Hiroshima 737-0112, JapanLaboratory of Neuropharmacology, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1, Hirokoshingai, Kure, Hiroshima 737-0112, JapanLaboratory of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1, Hirokoshingai, Kure, Hiroshima 737-0112, JapanEarly life adversity, such as neglect, increases the risk for major depressive disorder and anxiety disorders. It is well-known that astrocytes have key roles in brain function. In this paper, we show the effect of maternal separation (MS) coupled with social isolation on stress response and gene expression of glial fibrillary acidic protein (GFAP) as a marker of astrocytes, in early life and adulthood. Stress response was evaluated by using a forced swim test. GFAP gene expression level was evaluated by using the quantitative polymerase chain reaction (qPCR) method. The data in this article provide indexes affected by early life stress. Keywords: Maternal separation, Early life stress, GFAP, qPCR, Forced swim testhttp://www.sciencedirect.com/science/article/pii/S2352340918302609 |
| spellingShingle | Yosuke Yamawaki Misako Nishida Kana Harada Hiroyuki Akagi Data on the effect of maternal separation coupled with social isolation in a forced swim test and gene expression of glial fibrillary acid protein in the prefrontal cortex of rats Data in Brief |
| title | Data on the effect of maternal separation coupled with social isolation in a forced swim test and gene expression of glial fibrillary acid protein in the prefrontal cortex of rats |
| title_full | Data on the effect of maternal separation coupled with social isolation in a forced swim test and gene expression of glial fibrillary acid protein in the prefrontal cortex of rats |
| title_fullStr | Data on the effect of maternal separation coupled with social isolation in a forced swim test and gene expression of glial fibrillary acid protein in the prefrontal cortex of rats |
| title_full_unstemmed | Data on the effect of maternal separation coupled with social isolation in a forced swim test and gene expression of glial fibrillary acid protein in the prefrontal cortex of rats |
| title_short | Data on the effect of maternal separation coupled with social isolation in a forced swim test and gene expression of glial fibrillary acid protein in the prefrontal cortex of rats |
| title_sort | data on the effect of maternal separation coupled with social isolation in a forced swim test and gene expression of glial fibrillary acid protein in the prefrontal cortex of rats |
| url | http://www.sciencedirect.com/science/article/pii/S2352340918302609 |
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