Natural Compounds as Therapeutic Agents: The Case of Human Topoisomerase IB
Natural products are widely used as source for drugs development. An interesting example is represented by natural drugs developed against human topoisomerase IB, a ubiquitous enzyme involved in many cellular processes where several topological problems occur due the formation of supercoiled DNA. Hu...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/8/4138 |
| _version_ | 1797537482719363072 |
|---|---|
| author | Alessio Ottaviani Federico Iacovelli Paola Fiorani Alessandro Desideri |
| author_facet | Alessio Ottaviani Federico Iacovelli Paola Fiorani Alessandro Desideri |
| author_sort | Alessio Ottaviani |
| collection | DOAJ |
| description | Natural products are widely used as source for drugs development. An interesting example is represented by natural drugs developed against human topoisomerase IB, a ubiquitous enzyme involved in many cellular processes where several topological problems occur due the formation of supercoiled DNA. Human topoisomerase IB, involved in the solution of such problems relaxing the DNA cleaving and religating a single DNA strand, represents an important target in anticancer therapy. Several natural compounds inhibiting or poisoning this enzyme are under investigation as possible new drugs. This review summarizes the natural products that target human topoisomerase IB that may be used as the lead compounds to develop new anticancer drugs. Moreover, the natural compounds and their derivatives that are in clinical trial are also commented on. |
| first_indexed | 2024-03-10T12:15:46Z |
| format | Article |
| id | doaj.art-c60cebbc805d45df93e1c9ae40b37013 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T12:15:46Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c60cebbc805d45df93e1c9ae40b370132023-11-21T15:53:10ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01228413810.3390/ijms22084138Natural Compounds as Therapeutic Agents: The Case of Human Topoisomerase IBAlessio Ottaviani0Federico Iacovelli1Paola Fiorani2Alessandro Desideri3Department of Biology, University of Rome Tor Vergata, Via Della Ricerca Scientifica, 00133 Rome, ItalyDepartment of Biology, University of Rome Tor Vergata, Via Della Ricerca Scientifica, 00133 Rome, ItalyDepartment of Biology, University of Rome Tor Vergata, Via Della Ricerca Scientifica, 00133 Rome, ItalyDepartment of Biology, University of Rome Tor Vergata, Via Della Ricerca Scientifica, 00133 Rome, ItalyNatural products are widely used as source for drugs development. An interesting example is represented by natural drugs developed against human topoisomerase IB, a ubiquitous enzyme involved in many cellular processes where several topological problems occur due the formation of supercoiled DNA. Human topoisomerase IB, involved in the solution of such problems relaxing the DNA cleaving and religating a single DNA strand, represents an important target in anticancer therapy. Several natural compounds inhibiting or poisoning this enzyme are under investigation as possible new drugs. This review summarizes the natural products that target human topoisomerase IB that may be used as the lead compounds to develop new anticancer drugs. Moreover, the natural compounds and their derivatives that are in clinical trial are also commented on.https://www.mdpi.com/1422-0067/22/8/4138topoisomerasecancernatural products |
| spellingShingle | Alessio Ottaviani Federico Iacovelli Paola Fiorani Alessandro Desideri Natural Compounds as Therapeutic Agents: The Case of Human Topoisomerase IB International Journal of Molecular Sciences topoisomerase cancer natural products |
| title | Natural Compounds as Therapeutic Agents: The Case of Human Topoisomerase IB |
| title_full | Natural Compounds as Therapeutic Agents: The Case of Human Topoisomerase IB |
| title_fullStr | Natural Compounds as Therapeutic Agents: The Case of Human Topoisomerase IB |
| title_full_unstemmed | Natural Compounds as Therapeutic Agents: The Case of Human Topoisomerase IB |
| title_short | Natural Compounds as Therapeutic Agents: The Case of Human Topoisomerase IB |
| title_sort | natural compounds as therapeutic agents the case of human topoisomerase ib |
| topic | topoisomerase cancer natural products |
| url | https://www.mdpi.com/1422-0067/22/8/4138 |
| work_keys_str_mv | AT alessioottaviani naturalcompoundsastherapeuticagentsthecaseofhumantopoisomeraseib AT federicoiacovelli naturalcompoundsastherapeuticagentsthecaseofhumantopoisomeraseib AT paolafiorani naturalcompoundsastherapeuticagentsthecaseofhumantopoisomeraseib AT alessandrodesideri naturalcompoundsastherapeuticagentsthecaseofhumantopoisomeraseib |