Dual gene‐activated dermal scaffolds regulate angiogenesis and wound healing by mediating the coexpression of VEGF and angiopoietin‐1

Dual gene‐activated dermal scaffolds regulate angiogenesis and wound healing by mediating the coexpression of VEGF and angiopoietin‐1

Abstract The vascularization of dermal substitutes is a key challenge in efforts to heal deep skin defects. In this study, dual gene‐activated dermal scaffolds (DGADSs‐1) were fabricated by loading nanocomposite particles of polyethylenimine (PEI)/multiple plasmid DNAs (pDNAs) encoding vascular endo...

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Bibliographic Details
Main Authors: Tingting Weng, Min Yang, Wei Zhang, Ronghua Jin, Sizhan Xia, Manjia Zhang, Pan Wu, Xiaojie He, Chunmao Han, Xiong Zhao, Xingang Wang
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Bioengineering & Translational Medicine
Subjects:
angiogenesis
angiopoietin‐1
dual gene‐activated scaffolds
VEGF
wound healing
Online Access:https://doi.org/10.1002/btm2.10562

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