Backstage of Eating Disorder—About the Biological Mechanisms behind the Symptoms of Anorexia Nervosa
Anorexia nervosa (AN) represents a disorder with the highest mortality rate among all psychiatric diseases, yet our understanding of its pathophysiological components continues to be fragmentary. This article reviews the current concepts regarding AN pathomechanisms that focus on the main biological...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/9/2604 |
| _version_ | 1797555416634228736 |
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| author | Kamil Skowron Magdalena Kurnik-Łucka Emil Dadański Barbara Bętkowska-Korpała Krzysztof Gil |
| author_facet | Kamil Skowron Magdalena Kurnik-Łucka Emil Dadański Barbara Bętkowska-Korpała Krzysztof Gil |
| author_sort | Kamil Skowron |
| collection | DOAJ |
| description | Anorexia nervosa (AN) represents a disorder with the highest mortality rate among all psychiatric diseases, yet our understanding of its pathophysiological components continues to be fragmentary. This article reviews the current concepts regarding AN pathomechanisms that focus on the main biological aspects involving central and peripheral neurohormonal pathways, endocrine function, as well as the microbiome–gut–brain axis. It emerged from the unique complexity of constantly accumulating new discoveries, which hamper the ability to look at the disease in a more comprehensive way. The emphasis is placed on the mechanisms underlying the main symptoms and potential new directions that require further investigation in clinical settings. |
| first_indexed | 2024-03-10T16:47:11Z |
| format | Article |
| id | doaj.art-c60d970766f1484d848b114bc36f832c |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T16:47:11Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-c60d970766f1484d848b114bc36f832c2023-11-20T11:31:58ZengMDPI AGNutrients2072-66432020-08-01129260410.3390/nu12092604Backstage of Eating Disorder—About the Biological Mechanisms behind the Symptoms of Anorexia NervosaKamil Skowron0Magdalena Kurnik-Łucka1Emil Dadański2Barbara Bętkowska-Korpała3Krzysztof Gil4Department of Pathophysiology, Jagiellonian University Medical College, Czysta St 18, 31-121 Krakow, PolandDepartment of Pathophysiology, Jagiellonian University Medical College, Czysta St 18, 31-121 Krakow, PolandDepartment of Pathophysiology, Jagiellonian University Medical College, Czysta St 18, 31-121 Krakow, PolandDepartment of Psychiatry, Jagiellonian University Medical College, Institute of Medical Psychology, Jakubowskiego St 2, 30-688 Krakow, PolandDepartment of Pathophysiology, Jagiellonian University Medical College, Czysta St 18, 31-121 Krakow, PolandAnorexia nervosa (AN) represents a disorder with the highest mortality rate among all psychiatric diseases, yet our understanding of its pathophysiological components continues to be fragmentary. This article reviews the current concepts regarding AN pathomechanisms that focus on the main biological aspects involving central and peripheral neurohormonal pathways, endocrine function, as well as the microbiome–gut–brain axis. It emerged from the unique complexity of constantly accumulating new discoveries, which hamper the ability to look at the disease in a more comprehensive way. The emphasis is placed on the mechanisms underlying the main symptoms and potential new directions that require further investigation in clinical settings.https://www.mdpi.com/2072-6643/12/9/2604anorexia nervosaeating disordersstarvationhyperactivityneuropeptidesmicrobiome–gut–brain axis |
| spellingShingle | Kamil Skowron Magdalena Kurnik-Łucka Emil Dadański Barbara Bętkowska-Korpała Krzysztof Gil Backstage of Eating Disorder—About the Biological Mechanisms behind the Symptoms of Anorexia Nervosa Nutrients anorexia nervosa eating disorders starvation hyperactivity neuropeptides microbiome–gut–brain axis |
| title | Backstage of Eating Disorder—About the Biological Mechanisms behind the Symptoms of Anorexia Nervosa |
| title_full | Backstage of Eating Disorder—About the Biological Mechanisms behind the Symptoms of Anorexia Nervosa |
| title_fullStr | Backstage of Eating Disorder—About the Biological Mechanisms behind the Symptoms of Anorexia Nervosa |
| title_full_unstemmed | Backstage of Eating Disorder—About the Biological Mechanisms behind the Symptoms of Anorexia Nervosa |
| title_short | Backstage of Eating Disorder—About the Biological Mechanisms behind the Symptoms of Anorexia Nervosa |
| title_sort | backstage of eating disorder about the biological mechanisms behind the symptoms of anorexia nervosa |
| topic | anorexia nervosa eating disorders starvation hyperactivity neuropeptides microbiome–gut–brain axis |
| url | https://www.mdpi.com/2072-6643/12/9/2604 |
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