Decoding the multicellular ecosystem of vena caval tumor thrombus in clear cell renal cell carcinoma by single-cell RNA sequencing

Decoding the multicellular ecosystem of vena caval tumor thrombus in clear cell renal cell carcinoma by single-cell RNA sequencing

Abstract Background Vascular invasion with tumor thrombus frequently occurs in advanced renal cell carcinoma (RCC). Thrombectomy is one of the most challenging surgeries with high rate of perioperative morbidity and mortality. However, the mechanisms driving tumor thrombus formation are poorly under...

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Bibliographic Details
Main Authors: Yue Shi, Qi Zhang, Hai Bi, Min Lu, Yezhen Tan, Daojia Zou, Liyuan Ge, Zhigang Chen, Cheng Liu, Weimin Ci, Lulin Ma
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Genome Biology
Subjects:
Tumor thrombus
Clear cell renal cell carcinoma
Single-cell RNA sequencing
Tumor heterogeneity
Tumor microenvironment
Online Access:https://doi.org/10.1186/s13059-022-02651-9

Internet

https://doi.org/10.1186/s13059-022-02651-9

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