New image‐processing technology for endoscopic ultrasound‐guided fine‐needle aspiration biopsy specimen evaluation in patients with pancreatic cancer
Abstract Objectives We evaluated the usefulness of a newly developed system with which the total amount of whitish cores in endoscopic ultrasound‐guided fine‐needle aspiration biopsy (EUS‐FNAB) samples is automatically calculated (automated multiband imaging system [AMUS]). Methods From 30 prospecti...
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| Format: | Article |
| Language: | English |
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Wiley
2022-04-01
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| Series: | DEN Open |
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| Online Access: | https://doi.org/10.1002/deo2.21 |
| _version_ | 1818161863588839424 |
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| author | Kosuke Okuwaki Hiroshi Imaizumi Mitsuhiro Kida Hironori Masutani Masafumi Watanabe Kai Adachi Masayoshi Tadehara Akihiro Tamaki Tomohisa Iwai Hiroshi Yamauchi Rikiya Hasegawa Toru Kaneko Takahiro Kurosu Wasaburo Koizumi |
| author_facet | Kosuke Okuwaki Hiroshi Imaizumi Mitsuhiro Kida Hironori Masutani Masafumi Watanabe Kai Adachi Masayoshi Tadehara Akihiro Tamaki Tomohisa Iwai Hiroshi Yamauchi Rikiya Hasegawa Toru Kaneko Takahiro Kurosu Wasaburo Koizumi |
| author_sort | Kosuke Okuwaki |
| collection | DOAJ |
| description | Abstract Objectives We evaluated the usefulness of a newly developed system with which the total amount of whitish cores in endoscopic ultrasound‐guided fine‐needle aspiration biopsy (EUS‐FNAB) samples is automatically calculated (automated multiband imaging system [AMUS]). Methods From 30 prospectively enrolled patients suspected of having pancreatic cancer, four EUS‐FNAB specimens per patient were obtained. Following AMUS calculations, two specimens were prepared after stereomicroscopy‐guided manual division into whitish and reddish sections (isolation group), and the other two were prepared without such division (no‐isolation group). The relation of the AMUS results pertaining to the length of the manually measured whitish cores (stereo‐microscopically visible white core [SVWC]) and the sample suitability for pathologic evaluation were analyzed. Results Histological diagnostic accuracy was 90%; median SVWC length, 14 mm; and median area of whitish core calculated using the AMUS, 13 mm2. The SVWC length correlated with whitish core amount (ρ = 0.83, p < 0.01) and adequacy score (ρ = 0.50, p < 0.01). The whitish core amount correlated with the adequacy score (ρ = 0.40, p < 0.01). The area under the receiver‐operating characteristic curve calculated for whitish core amount with respect to the histological diagnosis was 0.84 (p < 0.01; cutoff ≥ 8 mm2, sensitivity 92.5%). Subgroup analysis (isolation vs. no‐isolation group) revealed no significant between‐group differences in the median histological adequacy (p = 0.27) or tumor cell content ratio (p = 0.28). The median scores for degree of blood contamination were significantly lower in the isolation group than in the no‐isolation group (p < 0.01). Conclusion AMUS is a simple on‐site verification procedure for determining the appropriate sampling tissue quantity for high diagnostic accuracy. |
| first_indexed | 2024-12-11T16:24:32Z |
| format | Article |
| id | doaj.art-c6130e7b6cb94cb1bf817e3827e3cbab |
| institution | Directory Open Access Journal |
| issn | 2692-4609 |
| language | English |
| last_indexed | 2024-12-11T16:24:32Z |
| publishDate | 2022-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | DEN Open |
| spelling | doaj.art-c6130e7b6cb94cb1bf817e3827e3cbab2022-12-22T00:58:45ZengWileyDEN Open2692-46092022-04-0121n/an/a10.1002/deo2.21New image‐processing technology for endoscopic ultrasound‐guided fine‐needle aspiration biopsy specimen evaluation in patients with pancreatic cancerKosuke Okuwaki0Hiroshi Imaizumi1Mitsuhiro Kida2Hironori Masutani3Masafumi Watanabe4Kai Adachi5Masayoshi Tadehara6Akihiro Tamaki7Tomohisa Iwai8Hiroshi Yamauchi9Rikiya Hasegawa10Toru Kaneko11Takahiro Kurosu12Wasaburo Koizumi13Department of Gastroenterology Kitasato University School of Medicine Kanagawa JapanDepartment of Gastroenterology Kitasato University School of Medicine Kanagawa JapanDepartment of Gastroenterology Kitasato University School of Medicine Kanagawa JapanDepartment of Gastroenterology Kitasato University School of Medicine Kanagawa JapanDepartment of Gastroenterology Kitasato University School of Medicine Kanagawa JapanDepartment of Gastroenterology Kitasato University School of Medicine Kanagawa JapanDepartment of Gastroenterology Kitasato University School of Medicine Kanagawa JapanDepartment of Gastroenterology Kitasato University School of Medicine Kanagawa JapanDepartment of Gastroenterology Kitasato University School of Medicine Kanagawa JapanDepartment of Gastroenterology Kitasato University School of Medicine Kanagawa JapanDepartment of Gastroenterology Kitasato University School of Medicine Kanagawa JapanDepartment of Gastroenterology Kitasato University School of Medicine Kanagawa JapanDepartment of Gastroenterology Kitasato University School of Medicine Kanagawa JapanDepartment of Gastroenterology Kitasato University School of Medicine Kanagawa JapanAbstract Objectives We evaluated the usefulness of a newly developed system with which the total amount of whitish cores in endoscopic ultrasound‐guided fine‐needle aspiration biopsy (EUS‐FNAB) samples is automatically calculated (automated multiband imaging system [AMUS]). Methods From 30 prospectively enrolled patients suspected of having pancreatic cancer, four EUS‐FNAB specimens per patient were obtained. Following AMUS calculations, two specimens were prepared after stereomicroscopy‐guided manual division into whitish and reddish sections (isolation group), and the other two were prepared without such division (no‐isolation group). The relation of the AMUS results pertaining to the length of the manually measured whitish cores (stereo‐microscopically visible white core [SVWC]) and the sample suitability for pathologic evaluation were analyzed. Results Histological diagnostic accuracy was 90%; median SVWC length, 14 mm; and median area of whitish core calculated using the AMUS, 13 mm2. The SVWC length correlated with whitish core amount (ρ = 0.83, p < 0.01) and adequacy score (ρ = 0.50, p < 0.01). The whitish core amount correlated with the adequacy score (ρ = 0.40, p < 0.01). The area under the receiver‐operating characteristic curve calculated for whitish core amount with respect to the histological diagnosis was 0.84 (p < 0.01; cutoff ≥ 8 mm2, sensitivity 92.5%). Subgroup analysis (isolation vs. no‐isolation group) revealed no significant between‐group differences in the median histological adequacy (p = 0.27) or tumor cell content ratio (p = 0.28). The median scores for degree of blood contamination were significantly lower in the isolation group than in the no‐isolation group (p < 0.01). Conclusion AMUS is a simple on‐site verification procedure for determining the appropriate sampling tissue quantity for high diagnostic accuracy.https://doi.org/10.1002/deo2.21endoscopic ultrasound‐guided fine‐needle aspirationendosonographyhistology |
| spellingShingle | Kosuke Okuwaki Hiroshi Imaizumi Mitsuhiro Kida Hironori Masutani Masafumi Watanabe Kai Adachi Masayoshi Tadehara Akihiro Tamaki Tomohisa Iwai Hiroshi Yamauchi Rikiya Hasegawa Toru Kaneko Takahiro Kurosu Wasaburo Koizumi New image‐processing technology for endoscopic ultrasound‐guided fine‐needle aspiration biopsy specimen evaluation in patients with pancreatic cancer DEN Open endoscopic ultrasound‐guided fine‐needle aspiration endosonography histology |
| title | New image‐processing technology for endoscopic ultrasound‐guided fine‐needle aspiration biopsy specimen evaluation in patients with pancreatic cancer |
| title_full | New image‐processing technology for endoscopic ultrasound‐guided fine‐needle aspiration biopsy specimen evaluation in patients with pancreatic cancer |
| title_fullStr | New image‐processing technology for endoscopic ultrasound‐guided fine‐needle aspiration biopsy specimen evaluation in patients with pancreatic cancer |
| title_full_unstemmed | New image‐processing technology for endoscopic ultrasound‐guided fine‐needle aspiration biopsy specimen evaluation in patients with pancreatic cancer |
| title_short | New image‐processing technology for endoscopic ultrasound‐guided fine‐needle aspiration biopsy specimen evaluation in patients with pancreatic cancer |
| title_sort | new image processing technology for endoscopic ultrasound guided fine needle aspiration biopsy specimen evaluation in patients with pancreatic cancer |
| topic | endoscopic ultrasound‐guided fine‐needle aspiration endosonography histology |
| url | https://doi.org/10.1002/deo2.21 |
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