Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism

Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism

The transcription factor SREBP is a well-studied and major regulator of sterol and fatty acid metabolism. Here, the authors used haploid genetic screens to identify the Golgi-resident protein SPRING as a new modulator of SREBP by regulating the level of functional SREBP cleavage-activating protein (...

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Bibliographic Details
Main Authors: Anke Loregger, Matthijs Raaben, Joppe Nieuwenhuis, Josephine M. E. Tan, Lucas T. Jae, Lisa G. van den Hengel, Sebastian Hendrix, Marlene van den Berg, Saskia Scheij, Ji-Ying Song, Ivo J. Huijbers, Lona J. Kroese, Roelof Ottenhoff, Michel van Weeghel, Bart van de Sluis, Thijn Brummelkamp, Noam Zelcer
Format: Article
Language:English
Published: Nature Portfolio 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14811-1

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