Fibromyalgia and Irritable Bowel Syndrome Interaction: A Possible Role for Gut Microbiota and Gut-Brain Axis
Fibromyalgia (FM) is a serious chronic pain syndrome, characterised by muscle and joint stiffness, insomnia, fatigue, mood disorders, cognitive dysfunction, anxiety, depression and intestinal irritability. Irritable Bowel Syndrome (IBS) shares many of these symptoms, and FM and IBS frequently co-exi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/6/1701 |
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| author | Cinzia Garofalo Costanza Maria Cristiani Sara Ilari Lucia Carmela Passacatini Valentina Malafoglia Giuseppe Viglietto Jessica Maiuolo Francesca Oppedisano Ernesto Palma Carlo Tomino William Raffaeli Vincenzo Mollace Carolina Muscoli |
| author_facet | Cinzia Garofalo Costanza Maria Cristiani Sara Ilari Lucia Carmela Passacatini Valentina Malafoglia Giuseppe Viglietto Jessica Maiuolo Francesca Oppedisano Ernesto Palma Carlo Tomino William Raffaeli Vincenzo Mollace Carolina Muscoli |
| author_sort | Cinzia Garofalo |
| collection | DOAJ |
| description | Fibromyalgia (FM) is a serious chronic pain syndrome, characterised by muscle and joint stiffness, insomnia, fatigue, mood disorders, cognitive dysfunction, anxiety, depression and intestinal irritability. Irritable Bowel Syndrome (IBS) shares many of these symptoms, and FM and IBS frequently co-exist, which suggests a common aetiology for the two diseases. The exact physiopathological mechanisms underlying both FM and IBS onset are unknown. Researchers have investigated many possible causes, including alterations in gut microbiota, which contain billions of microorganisms in the human digestive tract. The gut-brain axis has been proven to be the link between the gut microbiota and the central nervous system, which can then control the gut microbiota composition. In this review, we will discuss the similarities between FM and IBS. Particularly, we will focus our attention on symptomatology overlap between FM and IBS as well as the similarities in microbiota composition between FM and IBS patients. We will also briefly discuss the potential therapeutic approaches based on microbiota manipulations that are successfully used in IBS and could be employed also in FM patients to relieve pain, ameliorate the rehabilitation outcome, psychological distress and intestinal symptoms. |
| first_indexed | 2024-03-11T02:44:06Z |
| format | Article |
| id | doaj.art-c6137731042045938e0bace5c1feccab |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T02:44:06Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-c6137731042045938e0bace5c1feccab2023-11-18T09:26:59ZengMDPI AGBiomedicines2227-90592023-06-01116170110.3390/biomedicines11061701Fibromyalgia and Irritable Bowel Syndrome Interaction: A Possible Role for Gut Microbiota and Gut-Brain AxisCinzia Garofalo0Costanza Maria Cristiani1Sara Ilari2Lucia Carmela Passacatini3Valentina Malafoglia4Giuseppe Viglietto5Jessica Maiuolo6Francesca Oppedisano7Ernesto Palma8Carlo Tomino9William Raffaeli10Vincenzo Mollace11Carolina Muscoli12Department of Experimental and Clinical Medicine, “Magna Græcia” University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Sciences, Neuroscience Research Center, “Magna Græcia” University of Catanzaro, 88100 Catanzaro, ItalyPhysiology and Pharmacology of Pain, IRCCS San Raffaele Roma, 00166 Rome, ItalyDepartment of Health Science, Institute of Research for Food Safety & Health (IRC-FSH), “Magna Græcia” University of Catanzaro, 88100 Catanzaro, ItalyPhysiology and Pharmacology of Pain, IRCCS San Raffaele Roma, 00166 Rome, ItalyDepartment of Experimental and Clinical Medicine, “Magna Græcia” University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Health Science, Institute of Research for Food Safety & Health (IRC-FSH), “Magna Græcia” University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Health Science, Institute of Research for Food Safety & Health (IRC-FSH), “Magna Græcia” University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Health Science, Institute of Research for Food Safety & Health (IRC-FSH), “Magna Græcia” University of Catanzaro, 88100 Catanzaro, ItalyScientific Direction, IRCCS San Raffaele Roma, 00166 Rome, ItalyInstitute for Research on Pain, ISAL Foundation, Torre Pedrera, 47922 Rimini, ItalyDepartment of Health Science, Institute of Research for Food Safety & Health (IRC-FSH), “Magna Græcia” University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Health Science, Institute of Research for Food Safety & Health (IRC-FSH), “Magna Græcia” University of Catanzaro, 88100 Catanzaro, ItalyFibromyalgia (FM) is a serious chronic pain syndrome, characterised by muscle and joint stiffness, insomnia, fatigue, mood disorders, cognitive dysfunction, anxiety, depression and intestinal irritability. Irritable Bowel Syndrome (IBS) shares many of these symptoms, and FM and IBS frequently co-exist, which suggests a common aetiology for the two diseases. The exact physiopathological mechanisms underlying both FM and IBS onset are unknown. Researchers have investigated many possible causes, including alterations in gut microbiota, which contain billions of microorganisms in the human digestive tract. The gut-brain axis has been proven to be the link between the gut microbiota and the central nervous system, which can then control the gut microbiota composition. In this review, we will discuss the similarities between FM and IBS. Particularly, we will focus our attention on symptomatology overlap between FM and IBS as well as the similarities in microbiota composition between FM and IBS patients. We will also briefly discuss the potential therapeutic approaches based on microbiota manipulations that are successfully used in IBS and could be employed also in FM patients to relieve pain, ameliorate the rehabilitation outcome, psychological distress and intestinal symptoms.https://www.mdpi.com/2227-9059/11/6/1701fibromyalgiaIBSmicrobiota gut-brain axis |
| spellingShingle | Cinzia Garofalo Costanza Maria Cristiani Sara Ilari Lucia Carmela Passacatini Valentina Malafoglia Giuseppe Viglietto Jessica Maiuolo Francesca Oppedisano Ernesto Palma Carlo Tomino William Raffaeli Vincenzo Mollace Carolina Muscoli Fibromyalgia and Irritable Bowel Syndrome Interaction: A Possible Role for Gut Microbiota and Gut-Brain Axis Biomedicines fibromyalgia IBS microbiota gut-brain axis |
| title | Fibromyalgia and Irritable Bowel Syndrome Interaction: A Possible Role for Gut Microbiota and Gut-Brain Axis |
| title_full | Fibromyalgia and Irritable Bowel Syndrome Interaction: A Possible Role for Gut Microbiota and Gut-Brain Axis |
| title_fullStr | Fibromyalgia and Irritable Bowel Syndrome Interaction: A Possible Role for Gut Microbiota and Gut-Brain Axis |
| title_full_unstemmed | Fibromyalgia and Irritable Bowel Syndrome Interaction: A Possible Role for Gut Microbiota and Gut-Brain Axis |
| title_short | Fibromyalgia and Irritable Bowel Syndrome Interaction: A Possible Role for Gut Microbiota and Gut-Brain Axis |
| title_sort | fibromyalgia and irritable bowel syndrome interaction a possible role for gut microbiota and gut brain axis |
| topic | fibromyalgia IBS microbiota gut-brain axis |
| url | https://www.mdpi.com/2227-9059/11/6/1701 |
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