The pathological mechanisms of circRNAs in mediating intervertebral disc degeneration
Lower back pain (LBP) is a worldwide health problem associated with significant economic and social burden. Intervertebral disc degeneration (IVDD) is a leading cause of LBP. Several studies show that the death of nucleus pulposus cells (NPCs), abnormal metabolism of the extracellular matrix (ECM),...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2023-12-01
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| Series: | Non-coding RNA Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054023000604 |
| _version_ | 1827267562063265792 |
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| author | Yongjin Li Suzhe Zhou Xinli Hu Shibao Lu |
| author_facet | Yongjin Li Suzhe Zhou Xinli Hu Shibao Lu |
| author_sort | Yongjin Li |
| collection | DOAJ |
| description | Lower back pain (LBP) is a worldwide health problem associated with significant economic and social burden. Intervertebral disc degeneration (IVDD) is a leading cause of LBP. Several studies show that the death of nucleus pulposus cells (NPCs), abnormal metabolism of the extracellular matrix (ECM), and inflammatory response are the key mechanisms behind the pathogenesis of IVDD. Circular RNAs (circRNAs) are key regulators of gene expression and play a significant role in regulating NPCs death, ECM homeostasis, and inflammatory response by acting as microRNAs (miRNAs) sponges in IVDD. However, the regulatory role of circRNAs in mediating IVDD remains unknown. This review comprehensively describes the normal anatomic structure and function of IVD, the pathogenesis of IVDD, the characteristics, synthesis, mechanisms, and function of circRNAs. Moreover, we highlighted the 23 circRNAs that mediate ECM metabolism, 16 circRNAs that mediate NPCs apoptosis, circ_0004354 and circ_0040039 that mediate NPCs pyroptosis, and 5 circRNAs that mediate inflammatory response in IVDD. In addition, this review presents suggestions for future studies, such as the need for further investigation on ferroptosis-related circRNAs in IVDD. This review could provide novel insights into the pathogenesis and treatment of IVDD. |
| first_indexed | 2024-03-09T02:14:06Z |
| format | Article |
| id | doaj.art-c61454286c0540678accd816adbe8c80 |
| institution | Directory Open Access Journal |
| issn | 2468-0540 |
| language | English |
| last_indexed | 2025-03-22T04:35:43Z |
| publishDate | 2023-12-01 |
| publisher | KeAi Communications Co., Ltd. |
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| series | Non-coding RNA Research |
| spelling | doaj.art-c61454286c0540678accd816adbe8c802024-04-28T01:10:13ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402023-12-0184633640The pathological mechanisms of circRNAs in mediating intervertebral disc degenerationYongjin Li0Suzhe Zhou1Xinli Hu2Shibao Lu3Department of Orthopedics, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, China; National Clinical Research Center for Geriatric Diseases, Beijing, ChinaDepartment of Orthopedics, Anhui No 2 Provincial People's Hospital, Hefei, ChinaDepartment of Orthopedics, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, China; National Clinical Research Center for Geriatric Diseases, Beijing, ChinaDepartment of Orthopedics, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, China; National Clinical Research Center for Geriatric Diseases, Beijing, China; Corresponding author Department of Orthopedics, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, China.Lower back pain (LBP) is a worldwide health problem associated with significant economic and social burden. Intervertebral disc degeneration (IVDD) is a leading cause of LBP. Several studies show that the death of nucleus pulposus cells (NPCs), abnormal metabolism of the extracellular matrix (ECM), and inflammatory response are the key mechanisms behind the pathogenesis of IVDD. Circular RNAs (circRNAs) are key regulators of gene expression and play a significant role in regulating NPCs death, ECM homeostasis, and inflammatory response by acting as microRNAs (miRNAs) sponges in IVDD. However, the regulatory role of circRNAs in mediating IVDD remains unknown. This review comprehensively describes the normal anatomic structure and function of IVD, the pathogenesis of IVDD, the characteristics, synthesis, mechanisms, and function of circRNAs. Moreover, we highlighted the 23 circRNAs that mediate ECM metabolism, 16 circRNAs that mediate NPCs apoptosis, circ_0004354 and circ_0040039 that mediate NPCs pyroptosis, and 5 circRNAs that mediate inflammatory response in IVDD. In addition, this review presents suggestions for future studies, such as the need for further investigation on ferroptosis-related circRNAs in IVDD. This review could provide novel insights into the pathogenesis and treatment of IVDD.http://www.sciencedirect.com/science/article/pii/S2468054023000604Intervertebral disc degenerationNucleus pulposus cellsCircular RNAsExtracellular matrixInflammatory response |
| spellingShingle | Yongjin Li Suzhe Zhou Xinli Hu Shibao Lu The pathological mechanisms of circRNAs in mediating intervertebral disc degeneration Non-coding RNA Research Intervertebral disc degeneration Nucleus pulposus cells Circular RNAs Extracellular matrix Inflammatory response |
| title | The pathological mechanisms of circRNAs in mediating intervertebral disc degeneration |
| title_full | The pathological mechanisms of circRNAs in mediating intervertebral disc degeneration |
| title_fullStr | The pathological mechanisms of circRNAs in mediating intervertebral disc degeneration |
| title_full_unstemmed | The pathological mechanisms of circRNAs in mediating intervertebral disc degeneration |
| title_short | The pathological mechanisms of circRNAs in mediating intervertebral disc degeneration |
| title_sort | pathological mechanisms of circrnas in mediating intervertebral disc degeneration |
| topic | Intervertebral disc degeneration Nucleus pulposus cells Circular RNAs Extracellular matrix Inflammatory response |
| url | http://www.sciencedirect.com/science/article/pii/S2468054023000604 |
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