Pleural mesothelioma risk by industry and occupation: results from the Multicentre Italian Study on the Etiology of Mesothelioma (MISEM)
Abstract Background The Italian mesothelioma registry (ReNaM) estimates mesothelioma incidence and addresses its etiology by assessing cases’ exposures but cannot provide relative risk estimates. Objectives i) To estimate pleural mesothelioma relative risk by industry and occupation and by ReNaM cat...
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | Environmental Health |
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| Online Access: | https://doi.org/10.1186/s12940-022-00869-5 |
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| author | Enrica Migliore Dario Consonni Susan Peters Roel C. H. Vermeulen Hans Kromhout Antonio Baldassarre Domenica Cavone Elisabetta Chellini Corrado Magnani Carolina Mensi Enzo Merler Marina Musti Alessandro Marinaccio Dario Mirabelli |
| author_facet | Enrica Migliore Dario Consonni Susan Peters Roel C. H. Vermeulen Hans Kromhout Antonio Baldassarre Domenica Cavone Elisabetta Chellini Corrado Magnani Carolina Mensi Enzo Merler Marina Musti Alessandro Marinaccio Dario Mirabelli |
| author_sort | Enrica Migliore |
| collection | DOAJ |
| description | Abstract Background The Italian mesothelioma registry (ReNaM) estimates mesothelioma incidence and addresses its etiology by assessing cases’ exposures but cannot provide relative risk estimates. Objectives i) To estimate pleural mesothelioma relative risk by industry and occupation and by ReNaM categories of asbestos exposure; and ii) to provide quantitative estimates of the exposure–response relationship. Methods A population-based mesothelioma case–control study was conducted in 2012–2014 in five Italian regions. Cases and age and gender frequency-matched controls were interviewed using a standard ReNaM questionnaire. Experts coded work histories according to international standard classifications of industries/occupations and assigned asbestos exposure according to ReNaM categories. Job codes were further linked to SYN-JEM, a quantitative job-exposure matrix. Cumulative exposure (CE, f/mL-years) was computed by summing individual exposures over lifetime work history. Unconditional logistic regression analyses adjusted by gender, centre and age were fitted to calculate odds ratios (OR) and 95% confidence intervals (CI). Results Among men we observed increased risks of mesothelioma in many industries and associated occupations, including: asbestos-cement (OR = 3.43), manufacture of railroad equipment (OR = 8.07), shipbuilding and repairing (OR = 2.34), iron and steel mills (OR = 2.15), and construction (OR = 1.94). ORs by ReNaM exposure categories were as follows: definite/probable occupational exposure (OR = 15.8, men; OR = 8.80, women), possible occupational (OR = 2.82, men; OR = 3.70, women), sharing home with an exposed worker (OR = 2.55, men; OR = 10.3, women), residential (OR = 2.14, men; OR = 3.24, women). Based on SYN-JEM, mesothelioma risk increased by almost 30% per f/mL-year (OR = 1.28, CI 1.16–1.42). Conclusions Out study involved five regions with historically different types and levels of industrial development, encompassing one third of the Italian population and half of Italian mesothelioma cases. As expected, we found increased pleural mesothelioma risk in the asbestos industry and in trades with large consumption of asbestos materials. Clear associations were found using both qualitative (ReNaM classifications) and quantitative estimates (using SYN-JEM) of past asbestos exposure, with clear evidence of an exposure–response relationship. |
| first_indexed | 2024-04-12T13:48:44Z |
| format | Article |
| id | doaj.art-c6145ee774254cf9be8a5153aabf2b21 |
| institution | Directory Open Access Journal |
| issn | 1476-069X |
| language | English |
| last_indexed | 2024-04-12T13:48:44Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
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| series | Environmental Health |
| spelling | doaj.art-c6145ee774254cf9be8a5153aabf2b212022-12-22T03:30:35ZengBMCEnvironmental Health1476-069X2022-06-0121111310.1186/s12940-022-00869-5Pleural mesothelioma risk by industry and occupation: results from the Multicentre Italian Study on the Etiology of Mesothelioma (MISEM)Enrica Migliore0Dario Consonni1Susan Peters2Roel C. H. Vermeulen3Hans Kromhout4Antonio Baldassarre5Domenica Cavone6Elisabetta Chellini7Corrado Magnani8Carolina Mensi9Enzo Merler10Marina Musti11Alessandro Marinaccio12Dario Mirabelli13Cancer Epidemiology Unit, CPO Piemonte and University of TurinOccupational Health Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoDepartment of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht UniversityDepartment of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht UniversityDepartment of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht UniversityOccupational Medicine Unit, Careggi University HospitalInterdisciplinary Department of Medicine, Section of Occupational Medicine “B. Ramazzini”, University of BariUnit of Environmental and Occupational Epidemiology, Cancer Prevention and Research InstituteInterdepartmental Centre G. Scansetti for Studies On Asbestos and Other Toxic Particulates, University of TurinOccupational Health Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoOccupational Health Unit, Department of PreventionInterdisciplinary Department of Medicine, Section of Occupational Medicine “B. Ramazzini”, University of BariUnit of Occupational and Environmental Epidemiology - Italian Mesothelioma Register, Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers’ Compensation Authority (INAIL)Cancer Epidemiology Unit, CPO Piemonte and University of TurinAbstract Background The Italian mesothelioma registry (ReNaM) estimates mesothelioma incidence and addresses its etiology by assessing cases’ exposures but cannot provide relative risk estimates. Objectives i) To estimate pleural mesothelioma relative risk by industry and occupation and by ReNaM categories of asbestos exposure; and ii) to provide quantitative estimates of the exposure–response relationship. Methods A population-based mesothelioma case–control study was conducted in 2012–2014 in five Italian regions. Cases and age and gender frequency-matched controls were interviewed using a standard ReNaM questionnaire. Experts coded work histories according to international standard classifications of industries/occupations and assigned asbestos exposure according to ReNaM categories. Job codes were further linked to SYN-JEM, a quantitative job-exposure matrix. Cumulative exposure (CE, f/mL-years) was computed by summing individual exposures over lifetime work history. Unconditional logistic regression analyses adjusted by gender, centre and age were fitted to calculate odds ratios (OR) and 95% confidence intervals (CI). Results Among men we observed increased risks of mesothelioma in many industries and associated occupations, including: asbestos-cement (OR = 3.43), manufacture of railroad equipment (OR = 8.07), shipbuilding and repairing (OR = 2.34), iron and steel mills (OR = 2.15), and construction (OR = 1.94). ORs by ReNaM exposure categories were as follows: definite/probable occupational exposure (OR = 15.8, men; OR = 8.80, women), possible occupational (OR = 2.82, men; OR = 3.70, women), sharing home with an exposed worker (OR = 2.55, men; OR = 10.3, women), residential (OR = 2.14, men; OR = 3.24, women). Based on SYN-JEM, mesothelioma risk increased by almost 30% per f/mL-year (OR = 1.28, CI 1.16–1.42). Conclusions Out study involved five regions with historically different types and levels of industrial development, encompassing one third of the Italian population and half of Italian mesothelioma cases. As expected, we found increased pleural mesothelioma risk in the asbestos industry and in trades with large consumption of asbestos materials. Clear associations were found using both qualitative (ReNaM classifications) and quantitative estimates (using SYN-JEM) of past asbestos exposure, with clear evidence of an exposure–response relationship.https://doi.org/10.1186/s12940-022-00869-5Pleural mesotheliomaAsbestosOccupational exposureExposure assessmentCase–control study |
| spellingShingle | Enrica Migliore Dario Consonni Susan Peters Roel C. H. Vermeulen Hans Kromhout Antonio Baldassarre Domenica Cavone Elisabetta Chellini Corrado Magnani Carolina Mensi Enzo Merler Marina Musti Alessandro Marinaccio Dario Mirabelli Pleural mesothelioma risk by industry and occupation: results from the Multicentre Italian Study on the Etiology of Mesothelioma (MISEM) Environmental Health Pleural mesothelioma Asbestos Occupational exposure Exposure assessment Case–control study |
| title | Pleural mesothelioma risk by industry and occupation: results from the Multicentre Italian Study on the Etiology of Mesothelioma (MISEM) |
| title_full | Pleural mesothelioma risk by industry and occupation: results from the Multicentre Italian Study on the Etiology of Mesothelioma (MISEM) |
| title_fullStr | Pleural mesothelioma risk by industry and occupation: results from the Multicentre Italian Study on the Etiology of Mesothelioma (MISEM) |
| title_full_unstemmed | Pleural mesothelioma risk by industry and occupation: results from the Multicentre Italian Study on the Etiology of Mesothelioma (MISEM) |
| title_short | Pleural mesothelioma risk by industry and occupation: results from the Multicentre Italian Study on the Etiology of Mesothelioma (MISEM) |
| title_sort | pleural mesothelioma risk by industry and occupation results from the multicentre italian study on the etiology of mesothelioma misem |
| topic | Pleural mesothelioma Asbestos Occupational exposure Exposure assessment Case–control study |
| url | https://doi.org/10.1186/s12940-022-00869-5 |
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