Gene expression profiling reveals a possible role for somatostatin in the innate immune response of the liver
Somatostatin is a neuropeptide hormone that inhibits pituitary growth hormone (GH) release. Using microarray analysis of gene expression in the livers of wildtype control and somatostatin knockout mice, we have previously identified a panel of genes whose GH-dependent and sexually dimorphic expressi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-09-01
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| Series: | Genomics Data |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213596015000719 |
| _version_ | 1811204689435295744 |
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| author | Jessica M. Adams Malcolm J. Low |
| author_facet | Jessica M. Adams Malcolm J. Low |
| author_sort | Jessica M. Adams |
| collection | DOAJ |
| description | Somatostatin is a neuropeptide hormone that inhibits pituitary growth hormone (GH) release. Using microarray analysis of gene expression in the livers of wildtype control and somatostatin knockout mice, we have previously identified a panel of genes whose GH-dependent and sexually dimorphic expression patterns are significantly altered by the absence of somatostatin (1). Here, we provide methodological and analytical details of that study, the raw data of which is deposited in the Gene Expression Omnibus as data set GSE56520. In addition, we performed further gene ontology analysis of the data and found that the differential expression of a second subset of genes in the livers of somatostatin-knockout mice versus wildtype controls is likely independent of GH signaling and involved in the innate immune response. |
| first_indexed | 2024-04-12T03:16:44Z |
| format | Article |
| id | doaj.art-c6149309b0734ba691d5cabb446cd01f |
| institution | Directory Open Access Journal |
| issn | 2213-5960 |
| language | English |
| last_indexed | 2024-04-12T03:16:44Z |
| publishDate | 2015-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Genomics Data |
| spelling | doaj.art-c6149309b0734ba691d5cabb446cd01f2022-12-22T03:50:03ZengElsevierGenomics Data2213-59602015-09-015C424510.1016/j.gdata.2015.04.029Gene expression profiling reveals a possible role for somatostatin in the innate immune response of the liverJessica M. Adams0Malcolm J. Low1Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, United StatesDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United StatesSomatostatin is a neuropeptide hormone that inhibits pituitary growth hormone (GH) release. Using microarray analysis of gene expression in the livers of wildtype control and somatostatin knockout mice, we have previously identified a panel of genes whose GH-dependent and sexually dimorphic expression patterns are significantly altered by the absence of somatostatin (1). Here, we provide methodological and analytical details of that study, the raw data of which is deposited in the Gene Expression Omnibus as data set GSE56520. In addition, we performed further gene ontology analysis of the data and found that the differential expression of a second subset of genes in the livers of somatostatin-knockout mice versus wildtype controls is likely independent of GH signaling and involved in the innate immune response.http://www.sciencedirect.com/science/article/pii/S2213596015000719 |
| spellingShingle | Jessica M. Adams Malcolm J. Low Gene expression profiling reveals a possible role for somatostatin in the innate immune response of the liver Genomics Data |
| title | Gene expression profiling reveals a possible role for somatostatin in the innate immune response of the liver |
| title_full | Gene expression profiling reveals a possible role for somatostatin in the innate immune response of the liver |
| title_fullStr | Gene expression profiling reveals a possible role for somatostatin in the innate immune response of the liver |
| title_full_unstemmed | Gene expression profiling reveals a possible role for somatostatin in the innate immune response of the liver |
| title_short | Gene expression profiling reveals a possible role for somatostatin in the innate immune response of the liver |
| title_sort | gene expression profiling reveals a possible role for somatostatin in the innate immune response of the liver |
| url | http://www.sciencedirect.com/science/article/pii/S2213596015000719 |
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