Prevalence of human Papillomavirus associated oropharyngeal and oral squamous cell carcinoma in Asian countries: A systematic review and large-scale meta-analysis
Human Papillomavirus (HPV) associated with oropharyngeal and oral squamous cell carcinoma (OPSCC and OSCC) is escalating over the years. Hence, the present review aims to determine the prevalence of HPV-OSCC and HPV-OPSCC in Asian countries over the last decades. An electronic search was conducted u...
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| Format: | Article |
| Language: | English |
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Sciendo
2023-06-01
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| Series: | Acta Marisiensis - Seria Medica |
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| Online Access: | https://doi.org/10.2478/amma-2023-0005 |
| _version_ | 1797788970446225408 |
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| author | Tan Yy Jean Hou Ken Wong Siong Lin Galvin Sim Siang Wun Jasmine Lim Suk Nasir Wan Nor Amira Wan Ahmad Abdul Ko Lynn Wei Linn |
| author_facet | Tan Yy Jean Hou Ken Wong Siong Lin Galvin Sim Siang Wun Jasmine Lim Suk Nasir Wan Nor Amira Wan Ahmad Abdul Ko Lynn Wei Linn |
| author_sort | Tan Yy Jean |
| collection | DOAJ |
| description | Human Papillomavirus (HPV) associated with oropharyngeal and oral squamous cell carcinoma (OPSCC and OSCC) is escalating over the years. Hence, the present review aims to determine the prevalence of HPV-OSCC and HPV-OPSCC in Asian countries over the last decades. An electronic search was conducted using nine online databases to identify English-language articles on the prevalence of HPV-OPSCC and HPV-OSCC in Asian countries from January 2011 to June 2022. The risk of bias was assessed using the JBI critical appraisal checklist and the level of evidence was determined based on the OCEBM guideline. Single-arm meta-analysis was used to estimate the weighted mean prevalence of HPV-OPSCC and HPV-OSCC among patients in Asia. Subgroup analysis meta-regression and Egger’s tests were also conducted. 59 eligible studies were included with a higher prevalence of HPV-OPSCC (32.6%-37.4%) as compared to HPV-OSCC (10.9%-23.5%). Subgroup analysis revealed that the weighted mean prevalence of HPV-OPSCC was significantly higher (P<0.001) among East Asians, while the weighted mean prevalence of HPV-OSCC was significantly higher (P<0.001) among South Asians. All studies showed a low to moderate risk of bias with the level of evidence ranked between 2 and 3. The diagnostic tools utilised and geographical locations significantly affect the findings. |
| first_indexed | 2024-03-13T01:44:05Z |
| format | Article |
| id | doaj.art-c615223b38054b8985532b9672e83699 |
| institution | Directory Open Access Journal |
| issn | 2668-7763 |
| language | English |
| last_indexed | 2024-03-13T01:44:05Z |
| publishDate | 2023-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Marisiensis - Seria Medica |
| spelling | doaj.art-c615223b38054b8985532b9672e836992023-07-03T10:20:59ZengSciendoActa Marisiensis - Seria Medica2668-77632023-06-01692779210.2478/amma-2023-0005Prevalence of human Papillomavirus associated oropharyngeal and oral squamous cell carcinoma in Asian countries: A systematic review and large-scale meta-analysisTan Yy Jean0Hou Ken Wong Siong1Lin Galvin Sim Siang2Wun Jasmine Lim Suk3Nasir Wan Nor Amira Wan Ahmad Abdul4Ko Lynn Wei Linn51Oral and Maxillofacial Surgery Department, Dental Specialist Clinic, Sarawak General Hospital, Jalan Tun Ahmad Zaidi Adruce, Kuching, Sarawak, Malaysia2Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia3Department of Dental Materials, Faculty of Dentistry, Asian Institute of Medicine, Science and Technology (AIMST) University, Bedong, Kedah, Malaysia.4Batu Kawa Dental Clinic, Ministry of Health Malaysia, Kuching, Sarawak, Malaysia1Oral and Maxillofacial Surgery Department, Dental Specialist Clinic, Sarawak General Hospital, Jalan Tun Ahmad Zaidi Adruce, Kuching, Sarawak, Malaysia5Department of Paediatric Dentistry & Orthodontics, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, MalaysiaHuman Papillomavirus (HPV) associated with oropharyngeal and oral squamous cell carcinoma (OPSCC and OSCC) is escalating over the years. Hence, the present review aims to determine the prevalence of HPV-OSCC and HPV-OPSCC in Asian countries over the last decades. An electronic search was conducted using nine online databases to identify English-language articles on the prevalence of HPV-OPSCC and HPV-OSCC in Asian countries from January 2011 to June 2022. The risk of bias was assessed using the JBI critical appraisal checklist and the level of evidence was determined based on the OCEBM guideline. Single-arm meta-analysis was used to estimate the weighted mean prevalence of HPV-OPSCC and HPV-OSCC among patients in Asia. Subgroup analysis meta-regression and Egger’s tests were also conducted. 59 eligible studies were included with a higher prevalence of HPV-OPSCC (32.6%-37.4%) as compared to HPV-OSCC (10.9%-23.5%). Subgroup analysis revealed that the weighted mean prevalence of HPV-OPSCC was significantly higher (P<0.001) among East Asians, while the weighted mean prevalence of HPV-OSCC was significantly higher (P<0.001) among South Asians. All studies showed a low to moderate risk of bias with the level of evidence ranked between 2 and 3. The diagnostic tools utilised and geographical locations significantly affect the findings.https://doi.org/10.2478/amma-2023-0005asiaepidemiologymouth neoplasmhpvpolymerase chain reaction |
| spellingShingle | Tan Yy Jean Hou Ken Wong Siong Lin Galvin Sim Siang Wun Jasmine Lim Suk Nasir Wan Nor Amira Wan Ahmad Abdul Ko Lynn Wei Linn Prevalence of human Papillomavirus associated oropharyngeal and oral squamous cell carcinoma in Asian countries: A systematic review and large-scale meta-analysis Acta Marisiensis - Seria Medica asia epidemiology mouth neoplasm hpv polymerase chain reaction |
| title | Prevalence of human Papillomavirus associated oropharyngeal and oral squamous cell carcinoma in Asian countries: A systematic review and large-scale meta-analysis |
| title_full | Prevalence of human Papillomavirus associated oropharyngeal and oral squamous cell carcinoma in Asian countries: A systematic review and large-scale meta-analysis |
| title_fullStr | Prevalence of human Papillomavirus associated oropharyngeal and oral squamous cell carcinoma in Asian countries: A systematic review and large-scale meta-analysis |
| title_full_unstemmed | Prevalence of human Papillomavirus associated oropharyngeal and oral squamous cell carcinoma in Asian countries: A systematic review and large-scale meta-analysis |
| title_short | Prevalence of human Papillomavirus associated oropharyngeal and oral squamous cell carcinoma in Asian countries: A systematic review and large-scale meta-analysis |
| title_sort | prevalence of human papillomavirus associated oropharyngeal and oral squamous cell carcinoma in asian countries a systematic review and large scale meta analysis |
| topic | asia epidemiology mouth neoplasm hpv polymerase chain reaction |
| url | https://doi.org/10.2478/amma-2023-0005 |
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