Clinicopathological Features of Intrathoracic Liposarcoma—A Systematic Review with an Illustrative Case
Background: Liposarcoma (LPS) is one of the most common soft-tissue sarcomas. However, intrathoracic LPS is rare, as only 1% of all LPS cases are found in the thorax. Methods: A systematic literature review through PubMed and Embase databases was performed. Only eligible case reports and case series...
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MDPI AG
2022-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/24/7353 |
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| author | Kajetan Kiełbowski Nikola Ruszel Seweryn Adam Skrzyniarz Małgorzata Edyta Wojtyś Rafał Becht Konrad Ptaszyński Darko Gajić Janusz Wójcik |
| author_facet | Kajetan Kiełbowski Nikola Ruszel Seweryn Adam Skrzyniarz Małgorzata Edyta Wojtyś Rafał Becht Konrad Ptaszyński Darko Gajić Janusz Wójcik |
| author_sort | Kajetan Kiełbowski |
| collection | DOAJ |
| description | Background: Liposarcoma (LPS) is one of the most common soft-tissue sarcomas. However, intrathoracic LPS is rare, as only 1% of all LPS cases are found in the thorax. Methods: A systematic literature review through PubMed and Embase databases was performed. Only eligible case reports and case series reporting intrathoracic LPS in adult patients were included. Kaplan–Meier curves were calculated to evaluate the survival rate of included patients based on the histological subtype of LPS. Results: 123 studies reporting 197 patients were included. We added a case of a 69-year-old female patient with recurrent giant intrathoracic LPS. The primary tumor measured 15.1cm × 22.9 cm × 21.9 cm and weighed 3100 g. Six months later, the patient was admitted to the hospital with another intrathoracic tumor measuring 9.5 cm × 9 cm× 1.4 cm. The immunohistochemical studies showed expression of murine double minute 2 (MDM2) antigen in both primary and recurrent tumor cells. Conclusions: Dyspnea, chest pain, and cough were the most common symptoms reported in included studies. Overall, the 5-year survival rate was 62%. The highest survival was observed in well-differentiated LPS patients (80%) and the lowest in myxoid LPS (31%). |
| first_indexed | 2024-03-09T16:17:10Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T16:17:10Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-c615f01394b149fb880b84c57ef3e15d2023-11-24T15:44:07ZengMDPI AGJournal of Clinical Medicine2077-03832022-12-011124735310.3390/jcm11247353Clinicopathological Features of Intrathoracic Liposarcoma—A Systematic Review with an Illustrative CaseKajetan Kiełbowski0Nikola Ruszel1Seweryn Adam Skrzyniarz2Małgorzata Edyta Wojtyś3Rafał Becht4Konrad Ptaszyński5Darko Gajić6Janusz Wójcik7Department of Thoracic Surgery and Transplantation, Pomeranian Medical University in Szczecin, Alfreda Sokołowskiego 11, 70-891 Szczecin, PolandDepartment of Internal Medicine and Hypertension with Subdepartment of Cardiology, Independent Public Provincial Hospital in Szczecin, Alfreda Sokołowskiego 11, 70-891 Szczecin, PolandDietrich-Bonhoeffer-Klinikum, 17036 Neubrandenburg, GermanyDepartment of Thoracic Surgery and Transplantation, Pomeranian Medical University in Szczecin, Alfreda Sokołowskiego 11, 70-891 Szczecin, PolandDepartment of Clinical Oncology, Chemotherapy and Cancer Immunotherapy, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, PolandDepartment of Pathology, Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-561 Olsztyn, PolandDepartment of Thoracic Surgery and Transplantation, Pomeranian Medical University in Szczecin, Alfreda Sokołowskiego 11, 70-891 Szczecin, PolandDepartment of Thoracic Surgery and Transplantation, Pomeranian Medical University in Szczecin, Alfreda Sokołowskiego 11, 70-891 Szczecin, PolandBackground: Liposarcoma (LPS) is one of the most common soft-tissue sarcomas. However, intrathoracic LPS is rare, as only 1% of all LPS cases are found in the thorax. Methods: A systematic literature review through PubMed and Embase databases was performed. Only eligible case reports and case series reporting intrathoracic LPS in adult patients were included. Kaplan–Meier curves were calculated to evaluate the survival rate of included patients based on the histological subtype of LPS. Results: 123 studies reporting 197 patients were included. We added a case of a 69-year-old female patient with recurrent giant intrathoracic LPS. The primary tumor measured 15.1cm × 22.9 cm × 21.9 cm and weighed 3100 g. Six months later, the patient was admitted to the hospital with another intrathoracic tumor measuring 9.5 cm × 9 cm× 1.4 cm. The immunohistochemical studies showed expression of murine double minute 2 (MDM2) antigen in both primary and recurrent tumor cells. Conclusions: Dyspnea, chest pain, and cough were the most common symptoms reported in included studies. Overall, the 5-year survival rate was 62%. The highest survival was observed in well-differentiated LPS patients (80%) and the lowest in myxoid LPS (31%).https://www.mdpi.com/2077-0383/11/24/7353thoracic surgeryliposarcomaintrathoracic liposarcomawell-differentiated liposarcoma |
| spellingShingle | Kajetan Kiełbowski Nikola Ruszel Seweryn Adam Skrzyniarz Małgorzata Edyta Wojtyś Rafał Becht Konrad Ptaszyński Darko Gajić Janusz Wójcik Clinicopathological Features of Intrathoracic Liposarcoma—A Systematic Review with an Illustrative Case Journal of Clinical Medicine thoracic surgery liposarcoma intrathoracic liposarcoma well-differentiated liposarcoma |
| title | Clinicopathological Features of Intrathoracic Liposarcoma—A Systematic Review with an Illustrative Case |
| title_full | Clinicopathological Features of Intrathoracic Liposarcoma—A Systematic Review with an Illustrative Case |
| title_fullStr | Clinicopathological Features of Intrathoracic Liposarcoma—A Systematic Review with an Illustrative Case |
| title_full_unstemmed | Clinicopathological Features of Intrathoracic Liposarcoma—A Systematic Review with an Illustrative Case |
| title_short | Clinicopathological Features of Intrathoracic Liposarcoma—A Systematic Review with an Illustrative Case |
| title_sort | clinicopathological features of intrathoracic liposarcoma a systematic review with an illustrative case |
| topic | thoracic surgery liposarcoma intrathoracic liposarcoma well-differentiated liposarcoma |
| url | https://www.mdpi.com/2077-0383/11/24/7353 |
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