Estimated pulse wave velocity as a measure of vascular aging
<h4>Background</h4> Carotid-femoral pulse wave velocity (cfPWV), the referent measure of aortic stiffness, is an established measure of vascular aging. In studies where cfPWV cannot be measured, alternative methods are needed to help promote research on vascular aging. This study examine...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879446/?tool=EBI |
| _version_ | 1811176104940011520 |
|---|---|
| author | Kevin S. Heffernan Lee Stoner Andrew S. London Jacqueline A. Augustine Wesley K. Lefferts |
| author_facet | Kevin S. Heffernan Lee Stoner Andrew S. London Jacqueline A. Augustine Wesley K. Lefferts |
| author_sort | Kevin S. Heffernan |
| collection | DOAJ |
| description | <h4>Background</h4> Carotid-femoral pulse wave velocity (cfPWV), the referent measure of aortic stiffness, is an established measure of vascular aging. In studies where cfPWV cannot be measured, alternative methods are needed to help promote research on vascular aging. This study examines the construct validity of a measure of PWV estimated from age and blood pressure (ePWV). The specific aims of the study are to: 1) explore the strength of association between ePWV, cfPWV, and other established measures of vascular aging; 2) examine the sensitivity and specificity of elevated ePWV (≥10m/s) in relation to elevated cfPWV (≥10m/s). <h4>Methods</h4> We measured cfPWV in two-hundred and fifty-two adults (mean age 57±12 years, 48% female) and calculated each participant’s ePWV from their age and brachial blood pressure. Additional measures of vascular aging included: carotid intima-media thickness (cIMT); carotid stiffness measured as elastic modulus (cEp); and carotid augmentation index (cAIx). <h4>Results</h4> The correlations between cfPWV and measures of vascular aging were: cEp (r = 0.36), cIMT (r = 0.49), and cAIx (r = 0.04). The correlations between ePWV and measures of vascular aging were: cEp (r = 0.45), cIMT (r = 0.60), and cAIx (r = 0.24). The correlation between ePWV and cfPWV was (r = 0.67). The sensitivity and specificity of elevated ePWV (≥ 10 m/s) for concomitantly identifying high cfPWV (≥ 10 m/s) were 85.4% and 73.0% respectively. <h4>Conclusion</h4> ePWV is associated with established measures of vascular aging, such as carotid thickness, carotid stiffness and carotid augmentation index. ePWV may be a useful tool to help promote research on vascular aging. |
| first_indexed | 2024-04-10T19:46:42Z |
| format | Article |
| id | doaj.art-c618436025ee4b019bebfb2d4858bac1 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-10T19:46:42Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c618436025ee4b019bebfb2d4858bac12023-01-29T05:31:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01181Estimated pulse wave velocity as a measure of vascular agingKevin S. HeffernanLee StonerAndrew S. LondonJacqueline A. AugustineWesley K. Lefferts<h4>Background</h4> Carotid-femoral pulse wave velocity (cfPWV), the referent measure of aortic stiffness, is an established measure of vascular aging. In studies where cfPWV cannot be measured, alternative methods are needed to help promote research on vascular aging. This study examines the construct validity of a measure of PWV estimated from age and blood pressure (ePWV). The specific aims of the study are to: 1) explore the strength of association between ePWV, cfPWV, and other established measures of vascular aging; 2) examine the sensitivity and specificity of elevated ePWV (≥10m/s) in relation to elevated cfPWV (≥10m/s). <h4>Methods</h4> We measured cfPWV in two-hundred and fifty-two adults (mean age 57±12 years, 48% female) and calculated each participant’s ePWV from their age and brachial blood pressure. Additional measures of vascular aging included: carotid intima-media thickness (cIMT); carotid stiffness measured as elastic modulus (cEp); and carotid augmentation index (cAIx). <h4>Results</h4> The correlations between cfPWV and measures of vascular aging were: cEp (r = 0.36), cIMT (r = 0.49), and cAIx (r = 0.04). The correlations between ePWV and measures of vascular aging were: cEp (r = 0.45), cIMT (r = 0.60), and cAIx (r = 0.24). The correlation between ePWV and cfPWV was (r = 0.67). The sensitivity and specificity of elevated ePWV (≥ 10 m/s) for concomitantly identifying high cfPWV (≥ 10 m/s) were 85.4% and 73.0% respectively. <h4>Conclusion</h4> ePWV is associated with established measures of vascular aging, such as carotid thickness, carotid stiffness and carotid augmentation index. ePWV may be a useful tool to help promote research on vascular aging.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879446/?tool=EBI |
| spellingShingle | Kevin S. Heffernan Lee Stoner Andrew S. London Jacqueline A. Augustine Wesley K. Lefferts Estimated pulse wave velocity as a measure of vascular aging PLoS ONE |
| title | Estimated pulse wave velocity as a measure of vascular aging |
| title_full | Estimated pulse wave velocity as a measure of vascular aging |
| title_fullStr | Estimated pulse wave velocity as a measure of vascular aging |
| title_full_unstemmed | Estimated pulse wave velocity as a measure of vascular aging |
| title_short | Estimated pulse wave velocity as a measure of vascular aging |
| title_sort | estimated pulse wave velocity as a measure of vascular aging |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879446/?tool=EBI |
| work_keys_str_mv | AT kevinsheffernan estimatedpulsewavevelocityasameasureofvascularaging AT leestoner estimatedpulsewavevelocityasameasureofvascularaging AT andrewslondon estimatedpulsewavevelocityasameasureofvascularaging AT jacquelineaaugustine estimatedpulsewavevelocityasameasureofvascularaging AT wesleyklefferts estimatedpulsewavevelocityasameasureofvascularaging |