Real-time automatic temperature regulation during in vivo MRI-guided laser-induced thermotherapy (MR-LITT)
Abstract Precise control of tissue temperature during Laser-Induced Thermotherapy (LITT) procedures has the potential to improve the clinical efficiency and safety of such minimally invasive therapies. We present a method to automatically regulate in vivo the temperature increase during LITT using r...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-29818-z |
| _version_ | 1797864657044635648 |
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| author | Manon Desclides Valéry Ozenne Pierre Bour Thibaut Faller Guillaume Machinet Christophe Pierre Stéphane Chemouny Bruno Quesson |
| author_facet | Manon Desclides Valéry Ozenne Pierre Bour Thibaut Faller Guillaume Machinet Christophe Pierre Stéphane Chemouny Bruno Quesson |
| author_sort | Manon Desclides |
| collection | DOAJ |
| description | Abstract Precise control of tissue temperature during Laser-Induced Thermotherapy (LITT) procedures has the potential to improve the clinical efficiency and safety of such minimally invasive therapies. We present a method to automatically regulate in vivo the temperature increase during LITT using real-time rapid volumetric Magnetic Resonance thermometry (8 slices acquired every second, with an in-plane resolution of 1.4 mmx1.4 mm and a slice thickness of 3 mm) using the proton-resonance frequency (PRF) shift technique. The laser output power is adjusted every second using a feedback control algorithm (proportional-integral-derivative controller) to force maximal tissue temperature in the targeted region to follow a predefined temperature–time profile. The root-mean-square of the difference between the target temperature and the measured temperature ranged between 0.5 °C and 1.4 °C, for temperature increases between + 5 °C to + 30 °C above body temperature and a long heating duration (up to 15 min), showing excellent accuracy and stability of the method. These results were obtained on a 1.5 T clinical MRI scanner, showing a potential immediate clinical application of such a temperature controller during MR-guided LITT. |
| first_indexed | 2024-04-09T22:56:40Z |
| format | Article |
| id | doaj.art-c6187742502e471dae31b63f1833e3e3 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T22:56:40Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-c6187742502e471dae31b63f1833e3e32023-03-22T11:16:37ZengNature PortfolioScientific Reports2045-23222023-02-0113111210.1038/s41598-023-29818-zReal-time automatic temperature regulation during in vivo MRI-guided laser-induced thermotherapy (MR-LITT)Manon Desclides0Valéry Ozenne1Pierre Bour2Thibaut Faller3Guillaume Machinet4Christophe Pierre5Stéphane Chemouny6Bruno Quesson7CNRS, CRMSB, UMR 5536, IHU Liryc, University of BordeauxCNRS, CRMSB, UMR 5536, IHU Liryc, University of BordeauxCertis TherapeuticsCertis TherapeuticsALPhANOVALPhANOVCertis TherapeuticsCNRS, CRMSB, UMR 5536, IHU Liryc, University of BordeauxAbstract Precise control of tissue temperature during Laser-Induced Thermotherapy (LITT) procedures has the potential to improve the clinical efficiency and safety of such minimally invasive therapies. We present a method to automatically regulate in vivo the temperature increase during LITT using real-time rapid volumetric Magnetic Resonance thermometry (8 slices acquired every second, with an in-plane resolution of 1.4 mmx1.4 mm and a slice thickness of 3 mm) using the proton-resonance frequency (PRF) shift technique. The laser output power is adjusted every second using a feedback control algorithm (proportional-integral-derivative controller) to force maximal tissue temperature in the targeted region to follow a predefined temperature–time profile. The root-mean-square of the difference between the target temperature and the measured temperature ranged between 0.5 °C and 1.4 °C, for temperature increases between + 5 °C to + 30 °C above body temperature and a long heating duration (up to 15 min), showing excellent accuracy and stability of the method. These results were obtained on a 1.5 T clinical MRI scanner, showing a potential immediate clinical application of such a temperature controller during MR-guided LITT.https://doi.org/10.1038/s41598-023-29818-z |
| spellingShingle | Manon Desclides Valéry Ozenne Pierre Bour Thibaut Faller Guillaume Machinet Christophe Pierre Stéphane Chemouny Bruno Quesson Real-time automatic temperature regulation during in vivo MRI-guided laser-induced thermotherapy (MR-LITT) Scientific Reports |
| title | Real-time automatic temperature regulation during in vivo MRI-guided laser-induced thermotherapy (MR-LITT) |
| title_full | Real-time automatic temperature regulation during in vivo MRI-guided laser-induced thermotherapy (MR-LITT) |
| title_fullStr | Real-time automatic temperature regulation during in vivo MRI-guided laser-induced thermotherapy (MR-LITT) |
| title_full_unstemmed | Real-time automatic temperature regulation during in vivo MRI-guided laser-induced thermotherapy (MR-LITT) |
| title_short | Real-time automatic temperature regulation during in vivo MRI-guided laser-induced thermotherapy (MR-LITT) |
| title_sort | real time automatic temperature regulation during in vivo mri guided laser induced thermotherapy mr litt |
| url | https://doi.org/10.1038/s41598-023-29818-z |
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