An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant

An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant

Summary: The nucleolar scaffold protein NPM1 is a multifunctional regulator of cellular homeostasis, genome integrity, and stress response. NPM1 mutations, known as NPM1c variants promoting its aberrant cytoplasmic localization, are the most frequent genetic alterations in acute myeloid leukemia (AM...

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Bibliographic Details
Main Authors: Hannah Mende, Anshu Khatri, Carolin Lange, Sergio Alejandro Poveda-Cuevas, Georg Tascher, Adriana Covarrubias-Pinto, Frank Löhr, Sebastian E. Koschade, Ivan Dikic, Christian Münch, Anja Bremm, Lorenzo Brunetti, Christian H. Brandts, Hannah Uckelmann, Volker Dötsch, Vladimir V. Rogov, Ramachandra M. Bhaskara, Stefan Müller
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723014961

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