Effects of childhood obesity and related genetic factors on precocious puberty: protocol for a multi-center prospective cohort study
Abstract Background Childhood obesity has important effects on the onset and development of puberty. Although a number of studies have confirmed the relationship between obesity and precocious puberty, little is known about the pleiotropic genes of obesity and precocious puberty and the interaction...
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | BMC Pediatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12887-022-03350-x |
| _version_ | 1818213549426606080 |
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| author | Tingting Yu Ying Yu Xiaoqing Li Peng Xue Xiaodan Yu Yao Chen Huijun Kong Cuilan Lin Xiumin Wang Hao Mei Dan Wang Shijian Liu |
| author_facet | Tingting Yu Ying Yu Xiaoqing Li Peng Xue Xiaodan Yu Yao Chen Huijun Kong Cuilan Lin Xiumin Wang Hao Mei Dan Wang Shijian Liu |
| author_sort | Tingting Yu |
| collection | DOAJ |
| description | Abstract Background Childhood obesity has important effects on the onset and development of puberty. Although a number of studies have confirmed the relationship between obesity and precocious puberty, little is known about the pleiotropic genes of obesity and precocious puberty and the interaction between genes and environment. There are four objectives: (1) to analyze the incidence of precocious puberty in the general population in China; (2) to verify the direct effect of obesity on children’s precocious puberty using a variety of methods; (3) to verify the effect of obesity and its risk gene polymorphism on precocious puberty in a prospective cohort study; and (4) to analyze the interaction effect of genes and environment on pubertal development. Methods We will conduct a multi-center prospective cohort study in three cities, which are selected in southern, central, and northern China, respectively. Primary schools in these cities will be selected by a stratified cluster random sampling method. Primary school students from grade 1 to grade 3 (6 to 10 years old) will be selected for the cohort with extensive baseline data collection, including assessment of pubertal development, family demographic information, early development, sleep pattern, dietary pattern, and physical activity. Participants will be followed up for at least three years, and long-term follow-up will depend on future funding. Discussion The findings of this multicenter prospective population-based cohort study may expand previous related puberty development research as well as provide important information on the mechanism of early puberty. Targeted interventions can also be developed to improve adolescent health problems related to puberty development based on the available evidence. Trial registration ClinicalTrials.gov Identifier: NCT04113070 , prospectively registered on October 2, 2019. |
| first_indexed | 2024-12-12T06:06:03Z |
| format | Article |
| id | doaj.art-c6188ffbc4634b9ca87a7498133aafac |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-12-12T06:06:03Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-c6188ffbc4634b9ca87a7498133aafac2022-12-22T00:35:17ZengBMCBMC Pediatrics1471-24312022-05-012211810.1186/s12887-022-03350-xEffects of childhood obesity and related genetic factors on precocious puberty: protocol for a multi-center prospective cohort studyTingting Yu0Ying Yu1Xiaoqing Li2Peng Xue3Xiaodan Yu4Yao Chen5Huijun Kong6Cuilan Lin7Xiumin Wang8Hao Mei9Dan Wang10Shijian Liu11Sanya Women and Children’s Hospital, managed by Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of MedicineSanya Women and Children’s Hospital, managed by Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of MedicineSanya Women and Children’s Hospital, managed by Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of MedicineSanya Women and Children’s Hospital, managed by Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of MedicineDepartment of Developmental and Behavioral Pediatrics, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of MedicineDepartment of Endocrinology and Genetic Metabolism, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of MedicineDepartment of Pediatrics, Qu Fu People’s HospitalBoai Hospital of Zhongshan, Southern Medical UniversityDepartment of Endocrinology and Genetic Metabolism, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of MedicineDepartment of Data Science, School of Population Health, University of Mississippi Medical CenterSanya Women and Children’s Hospital, managed by Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of MedicineSanya Women and Children’s Hospital, managed by Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of MedicineAbstract Background Childhood obesity has important effects on the onset and development of puberty. Although a number of studies have confirmed the relationship between obesity and precocious puberty, little is known about the pleiotropic genes of obesity and precocious puberty and the interaction between genes and environment. There are four objectives: (1) to analyze the incidence of precocious puberty in the general population in China; (2) to verify the direct effect of obesity on children’s precocious puberty using a variety of methods; (3) to verify the effect of obesity and its risk gene polymorphism on precocious puberty in a prospective cohort study; and (4) to analyze the interaction effect of genes and environment on pubertal development. Methods We will conduct a multi-center prospective cohort study in three cities, which are selected in southern, central, and northern China, respectively. Primary schools in these cities will be selected by a stratified cluster random sampling method. Primary school students from grade 1 to grade 3 (6 to 10 years old) will be selected for the cohort with extensive baseline data collection, including assessment of pubertal development, family demographic information, early development, sleep pattern, dietary pattern, and physical activity. Participants will be followed up for at least three years, and long-term follow-up will depend on future funding. Discussion The findings of this multicenter prospective population-based cohort study may expand previous related puberty development research as well as provide important information on the mechanism of early puberty. Targeted interventions can also be developed to improve adolescent health problems related to puberty development based on the available evidence. Trial registration ClinicalTrials.gov Identifier: NCT04113070 , prospectively registered on October 2, 2019.https://doi.org/10.1186/s12887-022-03350-xPrecocious pubertyObesityCohort studySingle nucleotide polymorphism |
| spellingShingle | Tingting Yu Ying Yu Xiaoqing Li Peng Xue Xiaodan Yu Yao Chen Huijun Kong Cuilan Lin Xiumin Wang Hao Mei Dan Wang Shijian Liu Effects of childhood obesity and related genetic factors on precocious puberty: protocol for a multi-center prospective cohort study BMC Pediatrics Precocious puberty Obesity Cohort study Single nucleotide polymorphism |
| title | Effects of childhood obesity and related genetic factors on precocious puberty: protocol for a multi-center prospective cohort study |
| title_full | Effects of childhood obesity and related genetic factors on precocious puberty: protocol for a multi-center prospective cohort study |
| title_fullStr | Effects of childhood obesity and related genetic factors on precocious puberty: protocol for a multi-center prospective cohort study |
| title_full_unstemmed | Effects of childhood obesity and related genetic factors on precocious puberty: protocol for a multi-center prospective cohort study |
| title_short | Effects of childhood obesity and related genetic factors on precocious puberty: protocol for a multi-center prospective cohort study |
| title_sort | effects of childhood obesity and related genetic factors on precocious puberty protocol for a multi center prospective cohort study |
| topic | Precocious puberty Obesity Cohort study Single nucleotide polymorphism |
| url | https://doi.org/10.1186/s12887-022-03350-x |
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