Vaccine-related influenza virus B infection in a child with an undiagnosed B-cell acute lymphoblastic leukemia

We report a case of Influenza type B (lineage Yamagata) infection in a child who received the live attenuated influenza virus vaccine before being diagnosed with B-cell acute lymphoblastic leukemia. The patient developed a mild disease that persisted for 18 days and resolved without antiviral treatm...

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Bibliographic Details
Main Authors: Giuseppe Di Pietra, Sarah Di Sopra, Valeria Conciatori, Enrico Lavezzo, Elisa Franchin, Maria Grazia Petris, Alessandra Biffi, Ignazio Castagliuolo, Cristiano Salata, Claudia Del Vecchio
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:International Journal of Infectious Diseases
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Online Access:http://www.sciencedirect.com/science/article/pii/S1201971224002558
Description
Summary:We report a case of Influenza type B (lineage Yamagata) infection in a child who received the live attenuated influenza virus vaccine before being diagnosed with B-cell acute lymphoblastic leukemia. The patient developed a mild disease that persisted for 18 days and resolved without antiviral treatment. The prolonged infection of an attenuated virus in an immunocompromised host might pose a risk of reversion or evolution to a more pathogenic strain. Prompt prevention, identification, and monitoring of similar cases are desirable to avoid the development of severe illness, which could complicate patient management.
ISSN:1201-9712