Glutamine metabolic reprogramming in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a lethal disease with limited management strategies and poor prognosis. Metabolism alternations have been frequently unveiled in HCC, including glutamine metabolic reprogramming. The components of glutamine metabolism, such as glutamine synthetase, glutamate dehydro...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1242059/full |
| _version_ | 1827867156415512576 |
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| author | Yanyan Ye Bodong Yu Bodong Yu Hua Wang Hua Wang Fengming Yi Fengming Yi |
| author_facet | Yanyan Ye Bodong Yu Bodong Yu Hua Wang Hua Wang Fengming Yi Fengming Yi |
| author_sort | Yanyan Ye |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is a lethal disease with limited management strategies and poor prognosis. Metabolism alternations have been frequently unveiled in HCC, including glutamine metabolic reprogramming. The components of glutamine metabolism, such as glutamine synthetase, glutamate dehydrogenase, glutaminase, metabolites, and metabolite transporters, are validated to be potential biomarkers of HCC. Increased glutamine consumption is confirmed in HCC, which fuels proliferation by elevated glutamate dehydrogenase or upstream signals. Glutamine metabolism also serves as a nitrogen source for amino acid or nucleotide anabolism. In addition, more glutamine converts to glutathione as an antioxidant in HCC to protect HCC cells from oxidative stress. Moreover, glutamine metabolic reprogramming activates the mTORC signaling pathway to support tumor cell proliferation. Glutamine metabolism targeting therapy includes glutamine deprivation, related enzyme inhibitors, and transporters inhibitors. Together, glutamine metabolic reprogramming plays a pivotal role in HCC identification, proliferation, and progression. |
| first_indexed | 2024-03-12T15:14:24Z |
| format | Article |
| id | doaj.art-c61b3abd66214a089acbc1212f90b21a |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-03-12T15:14:24Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-c61b3abd66214a089acbc1212f90b21a2023-08-11T17:29:18ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2023-08-011010.3389/fmolb.2023.12420591242059Glutamine metabolic reprogramming in hepatocellular carcinomaYanyan Ye0Bodong Yu1Bodong Yu2Hua Wang3Hua Wang4Fengming Yi5Fengming Yi6Department of Ultrasound, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaThe Second Clinical Medical College of Nanchang University, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaJiangxi Medical College, Nanchang University, Nanchang, ChinaDepartment of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaJiangxi Key Laboratory of Clinical and Translational Cancer Research, Nanchang, ChinaDepartment of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaJiangxi Key Laboratory of Clinical and Translational Cancer Research, Nanchang, ChinaHepatocellular carcinoma (HCC) is a lethal disease with limited management strategies and poor prognosis. Metabolism alternations have been frequently unveiled in HCC, including glutamine metabolic reprogramming. The components of glutamine metabolism, such as glutamine synthetase, glutamate dehydrogenase, glutaminase, metabolites, and metabolite transporters, are validated to be potential biomarkers of HCC. Increased glutamine consumption is confirmed in HCC, which fuels proliferation by elevated glutamate dehydrogenase or upstream signals. Glutamine metabolism also serves as a nitrogen source for amino acid or nucleotide anabolism. In addition, more glutamine converts to glutathione as an antioxidant in HCC to protect HCC cells from oxidative stress. Moreover, glutamine metabolic reprogramming activates the mTORC signaling pathway to support tumor cell proliferation. Glutamine metabolism targeting therapy includes glutamine deprivation, related enzyme inhibitors, and transporters inhibitors. Together, glutamine metabolic reprogramming plays a pivotal role in HCC identification, proliferation, and progression.https://www.frontiersin.org/articles/10.3389/fmolb.2023.1242059/fullhepatocellular carcinomaglutamine metabolic reprogrammingmetabolic targeting therapymTORCglutamine-related metabolites |
| spellingShingle | Yanyan Ye Bodong Yu Bodong Yu Hua Wang Hua Wang Fengming Yi Fengming Yi Glutamine metabolic reprogramming in hepatocellular carcinoma Frontiers in Molecular Biosciences hepatocellular carcinoma glutamine metabolic reprogramming metabolic targeting therapy mTORC glutamine-related metabolites |
| title | Glutamine metabolic reprogramming in hepatocellular carcinoma |
| title_full | Glutamine metabolic reprogramming in hepatocellular carcinoma |
| title_fullStr | Glutamine metabolic reprogramming in hepatocellular carcinoma |
| title_full_unstemmed | Glutamine metabolic reprogramming in hepatocellular carcinoma |
| title_short | Glutamine metabolic reprogramming in hepatocellular carcinoma |
| title_sort | glutamine metabolic reprogramming in hepatocellular carcinoma |
| topic | hepatocellular carcinoma glutamine metabolic reprogramming metabolic targeting therapy mTORC glutamine-related metabolites |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1242059/full |
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