Glutamine metabolic reprogramming in hepatocellular carcinoma

Glutamine metabolic reprogramming in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a lethal disease with limited management strategies and poor prognosis. Metabolism alternations have been frequently unveiled in HCC, including glutamine metabolic reprogramming. The components of glutamine metabolism, such as glutamine synthetase, glutamate dehydro...

Full description

Bibliographic Details
Main Authors:	Yanyan Ye, Bodong Yu, Hua Wang, Fengming Yi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-08-01
Series:	Frontiers in Molecular Biosciences
Subjects:	hepatocellular carcinoma glutamine metabolic reprogramming metabolic targeting therapy mTORC glutamine-related metabolites
Online Access:	https://www.frontiersin.org/articles/10.3389/fmolb.2023.1242059/full

Similar Items

Lipophagy-mediated cholesterol synthesis inhibition is required for the survival of hepatocellular carcinoma under glutamine deprivation
by: Youzi Kong, et al.
Published: (2023-07-01)

Inhibition of Glutamine Uptake Resensitizes Paclitaxel Resistance in SKOV3-TR Ovarian Cancer Cell via mTORC1/S6K Signaling Pathway
by: Gyeongmi Kim, et al.
Published: (2022-08-01)

A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells
by: Jun-Kyu Byun, et al.
Published: (2017-07-01)

Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1‐driven acute lymphoblastic leukemia
by: Tra Ly Nguyen, et al.
Published: (2021-05-01)

Reprogramming of glutamine metabolism and its impact on immune response in the tumor microenvironment
by: Guofeng Ma, et al.
Published: (2022-07-01)

Targeting mTORC2/HDAC3 Inhibits Stemness of Liver Cancer Cells Against Glutamine Starvation
by: Hui‐Lu Zhang, et al.
Published: (2022-07-01)

Blockage of glutamine-dependent anaplerosis affects mTORC1/2 activity and ultimately leads to cellular senescence-like response
by: Geng-You Liao, et al.
Published: (2019-05-01)

NASH, Fibrosis and Hepatocellular Carcinoma: Lipid Synthesis and Glutamine/Acetate Signaling
by: Yoshiaki Sunami
Published: (2020-09-01)

Inhibitory Effect of a Glutamine Antagonist on Proliferation and Migration of VSMCs via Simultaneous Attenuation of Glycolysis and Oxidative Phosphorylation
by: Hyeon Young Park, et al.
Published: (2021-05-01)

Glutamine Synthetase as a Therapeutic Target for Cancer Treatment
by: Go Woon Kim, et al.
Published: (2021-02-01)

Rethinking glutamine metabolism and the regulation of glutamine addiction by oncogenes in cancer
by: Rui Ni, et al.
Published: (2023-03-01)

Glutamine metabolism in the proliferation of GS-expression pituitary tumor cells
by: Jintao Hu, et al.
Published: (2020-03-01)

Exploiting the Achilles’ heel of cancer: disrupting glutamine metabolism for effective cancer treatment
by: Yuxin Fan, et al.
Published: (2024-03-01)

Increased Ammonium Toxicity in Response to Exogenous Glutamine in Metastatic Breast Cancer Cells
by: Violet A. Kiesel, et al.
Published: (2022-05-01)

Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3
by: Karina N. Gonzalez Herrera, et al.
Published: (2018-02-01)

The Involvement of Long Non-Coding RNAs in Glutamine-Metabolic Reprogramming and Therapeutic Resistance in Cancer
by: Jungwook Roh, et al.
Published: (2022-11-01)

SARS-CoV-2 and Glutamine: SARS-CoV-2 Triggered Pathogenesis via Metabolic Reprograming of Glutamine in Host Cells
by: Shiv Bharadwaj, et al.
Published: (2021-01-01)

The Unexpected Essentiality of glnA2 in Mycobacterium smegmatis Is Salvaged by Overexpression of the Global Nitrogen Regulator glnR, but Not by L-, D- or Iso-Glutamine
by: Nadya Rakovitsky, et al.
Published: (2018-09-01)

CAFs targeted ultrasound-responsive nanodroplets loaded V9302 and GLULsiRNA to inhibit melanoma growth via glutamine metabolic reprogramming and tumor microenvironment remodeling
by: Chen Ai, et al.
Published: (2023-07-01)

Energy metabolism pathways in breast cancer progression: The reprogramming, crosstalk, and potential therapeutic targets
by: Xuewei Zheng, et al.
Published: (2022-12-01)

4-Hydroxyphenylpyruvate Dioxygenase-Like Protein Promotes Pancreatic Cancer Cell Progression and Is Associated With Glutamine-Mediated Redox Balance
by: Xianglai Ye, et al.
Published: (2021-01-01)

SLC1A5 Prefers to Play as an Accomplice Rather Than an Opponent in Pancreatic Adenocarcinoma
by: Fangshi Xu, et al.
Published: (2022-03-01)

Deferoxamine Counteracts Cisplatin Resistance in A549 Lung Adenocarcinoma Cells by Increasing Vulnerability to Glutamine Deprivation-Induced Cell Death
by: Wen-Jun Liu, et al.
Published: (2022-01-01)

Coenzyme Q Depletion Reshapes MCF-7 Cells Metabolism
by: Wenping Wang, et al.
Published: (2020-12-01)

The role of metabolic reprogramming in pancreatic cancer chemoresistance
by: Chang Liu, et al.
Published: (2023-01-01)

Formyl-Peptide Receptor 2 Signaling Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming of Lung Cancer Cells
by: Tiziana Pecchillo Cimmino, et al.
Published: (2022-08-01)

Role of Glycolytic and Glutamine Metabolism Reprogramming on the Proliferation, Invasion, and Apoptosis Resistance through Modulation of Signaling Pathways in Glioblastoma
by: Cristina Trejo-Solis, et al.
Published: (2023-12-01)

MYC Rules: Leading Glutamine Metabolism toward a Distinct Cancer Cell Phenotype
by: Vincent Tambay, et al.
Published: (2021-09-01)

Pathological Consequences of Hepatic mTORC1 Dysregulation
by: Chun-Seok Cho, et al.
Published: (2020-08-01)

PEBP4 Directs the Malignant Behavior of Hepatocellular Carcinoma Cells via Regulating mTORC1 and mTORC2
by: Qiongfeng Chen, et al.
Published: (2022-08-01)

Non-Targeted UHPLC-Q-TOF/MS-Based Metabolomics Reveals a Metabolic Shift from Glucose to Glutamine in CPB Cells during ISKNV Infection Cycle
by: Xiaozhe Fu, et al.
Published: (2019-09-01)

FARSB Facilitates Hepatocellular Carcinoma Progression by Activating the mTORC1 Signaling Pathway
by: Yaofeng Wang, et al.
Published: (2023-11-01)

Glutamine and glutamate as vital metabolites
by: Newsholme P., et al.
Published: (2003-01-01)

Unbalanced Glutamine Partitioning between CD8T Cells and Cancer Cells Accompanied by Immune Cell Dysfunction in Hepatocellular Carcinoma
by: Jianfei Chen, et al.
Published: (2022-12-01)

Cancer-associated fibroblast-specific lncRNA LINC01614 enhances glutamine uptake in lung adenocarcinoma
by: Tongyan Liu, et al.
Published: (2022-10-01)

The role of glutamine metabolism in castration-resistant prostate cancer
by: Bing Zhao, et al.
Published: (2023-01-01)

UCP2 silencing restrains leukemia cell proliferation through glutamine metabolic remodeling
by: Tiphaine Sancerni, et al.
Published: (2022-10-01)

GOLM1 Stimulation of Glutamine Metabolism Promotes Osteoporosis via Inhibiting Osteogenic Differentiation of BMSCs
by: Guangsi Shen, et al.
Published: (2018-11-01)

Glutamine metabolism modulates chondrocyte inflammatory response
by: Manoj Arra, et al.
Published: (2022-08-01)

A novel lonidamine derivative targeting mitochondria to eliminate cancer stem cells by blocking glutamine metabolism
by: Qiang Wang, et al.
Published: (2023-04-01)