Homeostasis Imbalance of Microglia and Astrocytes Leads to Alteration in the Metabolites of the Kynurenine Pathway in LPS-Induced Depressive-Like Mice

Homeostasis Imbalance of Microglia and Astrocytes Leads to Alteration in the Metabolites of the Kynurenine Pathway in LPS-Induced Depressive-Like Mice

In the pathology-oriented study of depression, inflammation hypothesis has received increasing attention for recent years. To mimic the depressive state caused by inflammation, rodents injected intraperitoneally with lipopolysaccharide (LPS) are usually used to stimulate an immune response. However,...

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Bibliographic Details
Main Authors: Xue Tao, Mingzhu Yan, Lisha Wang, Yunfeng Zhou, Zhi Wang, Tianji Xia, Xinmin Liu, Ruile Pan, Qi Chang
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
lipopolysaccharide
depression
kynurenine pathway
microglia
astrocytes
Online Access:https://www.mdpi.com/1422-0067/21/4/1460

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